Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ryan John Hansen"'
Autor:
Michael J. Berna, Patrick I. Eacho, Ryan John Hansen, Thomas P. Beyer, Andrea E Sperry, Victor J. Wroblewski, Krista Schroeder
Publikováno v:
mAbs
A recent report described a novel mechanism of action for an anti-proprotein convertase subtilisin-kexin type 9 (PCSK9) monoclonal antibody (LY3015014, or LY), wherein the antibody has improved potency and duration of action due to the PCSK9 epitope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f329fd3fa05d9bccc02e341e2f483242
https://doi.org/10.1080/19420862.2016.1270490
https://doi.org/10.1080/19420862.2016.1270490
Autor:
John Michael Beals, Michael John de Veer, Mary Pat Knadler, Angela M. Siesky, Shun Li, Christopher J.H. Porter, M. Dodson Michael, Ryan John Hansen, Tri-Hung Nguyen, Kristina M. Campanale
Publikováno v:
Pharmaceutical Research
Purpose Determine the pharmacokinetics of insulin peglispro (BIL) in 5/6-nephrectomized rats and study the absorption in lymph duct cannulated (LDC) sheep. Methods BIL is insulin lispro modified with 20-kDa linear PEG at lysine B28 increasing the hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e283be45bfedc735efccf5b680fe6366
https://doi.org/10.1007/s11095-016-2014-1
https://doi.org/10.1007/s11095-016-2014-1
Autor:
John Michael Beals, Hui-Rong Qian, Steven D. Kahl, Xiaoping Ruan, Gordon B. Cutler, Andrew Mark Vick, Owens Rebecca Anne, Julie S. Moyers, Mark W. Farmen, M. Dodson Michael, Shun Li, Ryan John Hansen, Chen Zhang, Anja Koester
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 357:459-465
The aim of this research was to characterize the in vivo and in vitro properties of basal insulin peglispro (BIL), a new basal insulin, wherein insulin lispro was derivatized through the covalent and site-specific attachment of a 20-kDa polyethylene-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c2025f98992771961b7f38e68e34dd
https://doi.org/10.1124/jpet.115.231035
https://doi.org/10.1124/jpet.115.231035
Autor:
James Voelker, David B. Radtke, Ryan John Hansen, Jennifer Witcher, Elisa Gomez, Vishala Chindalore, Juliet McColm, Leijun Hu, Roy Fleischmann
Publikováno v:
British Journal of Clinical Pharmacology. 81:908-917
Aims Two phase 1 studies evaluated the pharmacokinetics (PK), safety and biological activity of tabalumab, a human monoclonal antibody against B-cell activating factor (BAFF), administered intravenously (i.v.) or subcutaneously (s.c.) in subjects wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bbf8d39b49a8625b55542048868b397
https://doi.org/10.1111/bcp.12860
https://doi.org/10.1111/bcp.12860
Autor:
Andrew Ihor Korytko, J. Jacobs, Andrea E Sperry, John Michael Beals, Jessica L. Friedrich, Amy L. Cox, Steven D. Kahl, Eric D. Hawkins, Julie S. Moyers, Hana E. Baker, Ryan John Hansen, Volker Schellenberger, Chen Zhang, Michael E. Christe, M. Dodson Michael, Debra L. Konkol, D. Bruce Baldwin
Publikováno v:
Diabetes. 67
To optimize the action of exogenously administered insulin, we employed XTEN® technology to create insulins with variably sized XTEN amino acid polymers. Recombinant fusions of XTEN polymers linked to insulin lispro with an A21G mutation were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e51120da1ca78912cf5dabd1af626da
https://doi.org/10.2337/db18-90-lb
https://doi.org/10.2337/db18-90-lb
Autor:
Ryan John Hansen, Leijun Hu
Publikováno v:
Journal of Pharmaceutical Sciences. 102:2898-2908
Over the last two decades, there has been a simultaneous explosion in the levels of activity and capability in both monoclonal antibody (mAb) drug development and in the use of quantitative pharmacologic models to facilitate drug development. Both of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118d76b084cb3680a979994070c01d4f
https://doi.org/10.1002/jps.23504
https://doi.org/10.1002/jps.23504
Autor:
Victor J. Wroblewski, Mark C. Kowala, Bomie Han, Patrick I. Eacho, Thomas P. Beyer, Krista Schroeder, Ryan John Hansen, Richard Todd Pickard
Publikováno v:
Journal of the American College of Cardiology. 65(10)
Monoclonal antibodies (Mabs) that neutralize proprotein convertase subtilisin-kexin type 9 (PCSK9) cause remarkable LDL cholesterol (LDL-C) lowering in human trials. It was reported that the efficacy is determined by the epitope of the PCSK9 Mab. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10473a5153bab59407c4a2d5c15c5ec
Autor:
Joseph P. Balthasar, Ryan John Hansen
Publikováno v:
Journal of Pharmaceutical Sciences. 92:1206-1215
Recently, our laboratory reported that intravenous immunoglobulin (IVIG) treatment increased antiplatelet antibody (7E3) clearance in a rat model of immune thrombocytopenic purpura (ITP). However, due to the multifaceted nature of IVIG therapy, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d39124d7998a95ec4a0d7828a8be24f
https://doi.org/10.1002/jps.10364
https://doi.org/10.1002/jps.10364
Autor:
Joseph P. Balthasar, Ryan John Hansen
Publikováno v:
Blood. 100:2087-2093
Experiments were conducted to investigate the effects of intravenous immunoglobulin (IVIG) in a rat model of immune thrombocytopenia (ITP). Rats were pretreated with 0 to 2 g/kg IVIG and then challenged with an antiplatelet antibody (7E3, 8 mg/kg). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36293f14a16986e72a97eec500dd11c3
https://doi.org/10.1182/blood.v100.6.2087.h81802002087_2087_2093
https://doi.org/10.1182/blood.v100.6.2087.h81802002087_2087_2093
Publikováno v:
Separation Science and Technology. 34:2583-2599
As a part of our study of hazardous metal ion separations, the extraction of Sr2+ and Pb2+ from solutions containing nitric acid and various nitrate salts has been investigated. High partition ratios (DSr > 100−10)) were observed using comparativel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c025b0da30b8dabbeef4a78319478575
https://doi.org/10.1081/ss-100100792
https://doi.org/10.1081/ss-100100792