Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ryan J. Lorenzo"'
Autor:
Zhiwei Hu, Laura Rowland-Faux, Stephan C. Jahn, Ryan J. Lorenzo, Margaret O. James, Guo Zhong, Katherine V. Cisneros, Peter W. Stacpoole, Marci Smeltz
Publikováno v:
Biochemical Pharmacology. 152:236-243
Biotransformation of dichloroacetate (DCA) to glyoxylate by hepatic glutathione transferase zeta 1 (GSTZ1) is considered the principal determinant of the rate of plasma clearance of the drug. However, several other organismal and subcellular factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c7547c175e9f914196a083633273e8
https://doi.org/10.1016/j.bcp.2018.04.001
https://doi.org/10.1016/j.bcp.2018.04.001
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
Autor:
Mohamed Hassan M. Solayman, Stephan C. Jahn, Taimour Y. Langaee, Ryan J. Lorenzo, Margaret O. James, Peter W. Stacpoole
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:1202-1210
Dichloroacetate (DCA), commonly used to treat metabolic disorders, is under investigation as an anti-cancer therapy due to its ability to reverse the Warburg effect and induce apoptosis in tumor cells. While DCA’s mechanism of action is well-studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db93f14352d3978cc1c0f639799faadf
https://doi.org/10.1016/j.bbagen.2016.01.024
https://doi.org/10.1016/j.bbagen.2016.01.024
Autor:
Taimour Y. Langaee, Margaret O. James, Stephan C. Jahn, Peter W. Stacpoole, Mohamed H. Solaymen, Ryan J. Lorenzo
Publikováno v:
Molecular Cancer Research. 14:A62-A62
Dichloroacetate (DCA), a small molecule commonly used to treat metabolic disorders, is under investigation as an anti-cancer therapy due to its ability to reverse the Warburg effect and induce apoptosis. While DCA's mechanism of action is well-studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2beeeca56bf289bfd8101b11cc782402
https://doi.org/10.1158/1557-3125.metca15-a62
https://doi.org/10.1158/1557-3125.metca15-a62
Autor:
Stephan C. Jahn, Ryan J. Lorenzo
Publikováno v:
Postdoc Journal. 3(2):33
Dichloroacetate (DCA) has been used for many years as an investigational drug to treat children born with mitochondrial disorders. Through its inhibition of Pyruvate Dehydrogenase Kinase (PDK), a key component of the pyruvate dehydrogenase complex, D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f6730e23573447ba641036998084d9
https://doi.org/10.14304/SURYA.JPR.V3N2.5
https://doi.org/10.14304/SURYA.JPR.V3N2.5