Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ryan J. Linder"'
Autor:
Lysiane Huber, David Anthony Barda, Youyan Zhang, Sheng-Bin Peng, Xueqian Gong, Junpeng Xiao, Deqi Guo, Jing Wang, Carmen Curtis, Bradley L. Ackermann, Wayne P. Bocchinfuso, Danalyn Manglicmot, Gregory P. Donoho, Paul D. Cornwell, Ryan J. Linder, Chong Si, Lee J. Burns, Michael J. Chalmers, Xi Lin, Denis J. McCann, Henry James Robert, Robert D. Van Horn, Serge Louis Boulet, Melbert-Brian D. Saflor, John Strelow, Lian Zhou
Publikováno v:
Cancer Research. 81:1259-1259
KRAS-G12C is an important oncogenic mutation in patients with NSCLC, CRC, and other cancer types. Currently, there are no FDA-approved KRAS-G12C inhibitors, and those in clinical development have relatively modest activity compared to other approved
Autor:
Tony Y. Zhang, Hannah Yu, John R. Rizzo, Jeffrey A. Ward, Thomas M. Koenig, Rachel N. Richey, David Mitchell, Marvin M. Hansen, Neil J. Kallman, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 21:208-217
A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development
Autor:
Marvin M. Hansen, Jennifer Kuehne-Willmore, Amy C. DeBaillie, Molly Harding, Joseph R. Martinelli, Daniel J. Jarmer, Michael J. McCulley, Dominique Huber, Michael E. Laurila, Thomas J. Martin, David W. Hoard, Theo Zweifel, Ryan J. Linder, Stanley P. Kolis, Nikolay Zaborenko, Enver Arslantas, Rachel N. Richey, Derek R. Starkey, Thomas Kull, Adrienne Hollister, Jeffrey A. Ward, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 19:1214-1230
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl
Autor:
Nikolay Zaborenko, Marvin M. Hansen, Bradley M. Campbell, Ryan J. Linder, Martin D. Johnson, Timothy M. Braden
Publikováno v:
Organic Process Research & Development. 19:1231-1243
The design, development, and implementation of a pilot-scale continuous hydrogenolysis in a catalytic packed bed to generate a starting material is described. Control of a critical defluorination impurity under the reaction conditions has been achiev
Publikováno v:
Organic Process Research & Development. 19:1507-1516
Despite a recent publication describing boronic acids as a “novel class of bacterial mutagen,” process and analytical chemists may not be aware of the potential worker exposure hazards, or of the need to assess boron compounds as potential genoto
Autor:
Eugene F. Kogut, Neil J. Kallman, Dana L. T. Laird, Marvin M. Hansen, J. Craig Ruble, Chin Liu, Lawrence Edward Patterson, Matthew H. Yates, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 18:501-510
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and de
Autor:
Justin C. Smith, Samuel Dean Larsen, Leland Otto Weigel, Jeffrey A. Ward, Ryan J. Linder, Susan M. Reutzel-Edens, Perry Clark Heath, Stanley P. Kolis, Marvin M. Hansen, Marcella T. Clayton, Sandra S. K. Borders, Shella Lenyonga Tameze
Publikováno v:
Organic Process Research & Development. 13:198-208
An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core from 6-nitroindanone using a five-step literature route. The second-generation route used a
Autor:
Moher Eric D, John Allan Rieck, Richard D. Miller, Tracy K. Ditsworth, David A. Hay, Sandra S. K. Borders, Mindy B. Forst, Richard C. Hoying, and Duane A. Pierson, Joseph A. Turpin, Varie David Lee, Ryan J. Linder, Jason S. Cronin, David D. Anderson, and Jacob R. Remacle, Molly D. Brady, Hoard David W, Paul N. Dodson, Christopher A. Beck
Publikováno v:
Organic Process Research & Development. 11:546-559
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcoh
Publikováno v:
Tetrahedron Letters. 47:7209-7212
A mixture of cyclohexanone or 4-methylcyclohexanone and an aromatic aldehyde is treated with dimethylsulfoxonium methylide to effect a tandem aldol/epoxidation reaction. The resulting product contains three or four new stereocenters but only one of t
Publikováno v:
Organic Process Research & Development; Nov2015, Vol. 19 Issue 11, p1507-1516, 10p