Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ryan J. King"'
Metabolic and Immunological Subtypes of Esophageal Cancer Reveal Potential Therapeutic Opportunities
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundEsophageal cancer has the sixth highest rate of cancer-associated deaths worldwide, with many patients displaying metastases and chemotherapy resistance. We sought to find subtypes to see if precision medicine could play a role in finding n
Externí odkaz:
https://doaj.org/article/4f8e8d4985ab4cf3a1becd51154faae9
Autor:
Ryan J. King, Surendra K. Shukla, Chunbo He, Enza Vernucci, Ravi Thakur, Kuldeep S. Attri, Aneesha Dasgupta, Nina V. Chaika, Scott E. Mulder, Jaime Abrego, Divya Murthy, Venugopal Gunda, Camila G. Pacheco, Paul M. Grandgenett, Audrey J. Lazenby, Michael A. Hollingsworth, Fang Yu, Kamiya Mehla, Pankaj K. Singh
Publikováno v:
Oncogene. 41:971-982
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0dce488cdfbc65b01dce4e49232e21
https://doi.org/10.1038/s41388-021-02132-6
https://doi.org/10.1038/s41388-021-02132-6
Autor:
Pankaj K. Singh, Chi Lin, Tadayoshi Bessho, Fang Yu, Shuo Wang, Sicong Li, Ryan J. King, Nina V. Chaika, Aneesha Dasgupta, Enza Vernucci, Gennifer D. Goode, Surendra K. Shukla, Jaime Abrego, Joshua Souchek, Venugopal Gunda
Figure S1. BrPA inhibits MUC1-mediated nucleotide metabolism. Figure S2. Immunohistochemical staining for MUC1 in tumor sections.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244741d34c5642c77c072e2e5d68916
https://doi.org/10.1158/1078-0432.22467183.v1
https://doi.org/10.1158/1078-0432.22467183.v1
Data from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer
Autor:
Pankaj K. Singh, Chi Lin, Tadayoshi Bessho, Fang Yu, Shuo Wang, Sicong Li, Ryan J. King, Nina V. Chaika, Aneesha Dasgupta, Enza Vernucci, Gennifer D. Goode, Surendra K. Shukla, Jaime Abrego, Joshua Souchek, Venugopal Gunda
Purpose: MUC1, an oncogene overexpressed in multiple solid tumors, including pancreatic cancer, reduces overall survival and imparts resistance to radiation and chemotherapies. We previously identified that MUC1 facilitates growth-promoting metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a38913aee94df543f33836c0388a54
https://doi.org/10.1158/1078-0432.c.6526560.v1
https://doi.org/10.1158/1078-0432.c.6526560.v1
Autor:
Pankaj K. Singh, Aaron R. Sasson, Jean Grem, Lyudmyla Berim, Audrey J. Lazenby, Fang Yu, Nina V. Chaika, Jaime Abrego, Enza Vernucci, Venugopal Gunda, Ryan J. King, Surendra K. Shukla, Saber Tadros
Figure S1: FASN inhibition with orlistat shows synergistic activity with gemcitabine in AsPC-1 cells; Figure S2: Effect of orlistat on the lipid content of pancreatic cancer cells; Figure S3: Platensimycin shows synergistic activity with gemcitabine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596cf661396a3ee8aaf765d72fe2857b
https://doi.org/10.1158/0008-5472.22414755
https://doi.org/10.1158/0008-5472.22414755
Autor:
Pankaj K. Singh, Aaron R. Sasson, Jean Grem, Lyudmyla Berim, Audrey J. Lazenby, Fang Yu, Nina V. Chaika, Jaime Abrego, Enza Vernucci, Venugopal Gunda, Ryan J. King, Surendra K. Shukla, Saber Tadros
Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although the prognosis in pancreatic cancer remains grim in part due to poor response to therapy, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01df4e3ea24249e070fa6c7886c161f4
https://doi.org/10.1158/0008-5472.c.6509073.v1
https://doi.org/10.1158/0008-5472.c.6509073.v1
Autor:
Clemens Steegborn, Chunbo He, Fang Yu, Antonello Mai, Kuldeep S. Attri, Sarika Chaudhary, Eric Verdin, Ping Lan, Tuo Hu, Sergio Valente, Surendra K. Shukla, Audrey J. Lazenby, Enza Vernucci, Ravi Thakur, David A. Tuveson, Divya Murthy, Xiao Fu, Nicholas J Mullen, Dante Rotili, Ryan J. King, Pankaj Singh, Dezhen Wang, Kamiya Mehla, Marco Tafani, Scott E. Mulder, Robin High, Kanupriya Jha, Johan Auwerx, Nina V. Chaika, Kasturi Siddhanta, Camila G. Pacheco
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467d75d337ef5dbb97182174d32e9b77
https://doi.org/10.1053/j.gastro.2021.06.045
https://doi.org/10.1053/j.gastro.2021.06.045
Autor:
Ryan J. King, Kuldeep S. Attri, Fang Yu, Surendra K. Shukla, Spas Dimitrov Markov, Enza Vernucci, Kamiya Mehla, Michael A. Hollingsworth, Pankaj K. Singh, Aneesha Dasgupta, Paul M. Grandgenett
Publikováno v:
Cancer Lett
Incidence of cachexia is highly prevalent in pancreatic ductal adenocarcinoma (PDAC); advanced disease stage directly correlates with decreased muscle and fat mass in PDAC patients. The pancreatic tumor microenvironment is central to the release of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcf5b4b56896550dcb7662ac71c3042
https://doi.org/10.1016/j.canlet.2020.04.017
https://doi.org/10.1016/j.canlet.2020.04.017
Publikováno v:
Oncogene
The Mucin 1 (MUC1) protein is overexpressed in various cancers and mediates chemotherapy resistance. However, the mechanism is not fully understood. Given that most chemotherapeutic drugs disrupt ER homeostasis as part of their toxicity, and MUC1 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224f0ff2910cb75469be4d0104f4eac2
http://europepmc.org/articles/PMC7165067
http://europepmc.org/articles/PMC7165067
Autor:
Yiwen Song, Jian Xiao, Jiancong Hu, Feng-Wei Wang, Zhenxing Liang, Xiaowen He, Xianrui Wu, Ping Lan, Xiaobin Zheng, Yunfeng Zhang, Tuo Hu, Ryan J. King, Huashan Liu, Chi Zhou
Publikováno v:
Theranostics
Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its role in regulating immune-unrelated biological processes such as proliferation and metastasis remains unclear. We seek to explore the immune-independent functions of CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fdff3a674225aee76b4e2e904525f9
https://doi.org/10.7150/thno.40860
https://doi.org/10.7150/thno.40860