Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ryan J. Holland"'
Autor:
Anna E. Maciag, Ryan J. Holland, Y.-S. Robert Cheng, Luis G. Rodriguez, Joseph E. Saavedra, Lucy M. Anderson, Larry K. Keefer
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metaboli
Externí odkaz:
https://doaj.org/article/96cd776291404d5f928d6f807e7ad475
Autor:
Valentyna I. Fesenkova, Larry K. Keefer, Charlotte Hanson, Monika Z. Kaczmarek, Stephen A. Lavanier, Ryan J. Holland, Joseph E. Saavedra, Jami A. Troxler, Joan L. Cmarik, Sandra K. Ruscetti
Publikováno v:
Leukemia Research. 38:377-382
The nitric oxide (NO) prodrug JS-K, a promising anti-cancer agent, consists of a diazeniumdiolate group necessary for the release of NO as well as an arylating ring. In this study, we research the mechanism by which JS-K kills a murine erythroleukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567b71e10c63a95740105a4b1e0c8fa6
https://doi.org/10.1016/j.leukres.2013.12.002
https://doi.org/10.1016/j.leukres.2013.12.002
Autor:
Larry K. Keefer, Rika Paulisch, Ryan J. Holland, Sonia Donzelli, Joseph E. Saavedra, Zhao Cao
Publikováno v:
Nitric Oxide. 35:131-136
We introduce a strategy for generating mixtures of nitric oxide (NO) and nitroxyl (HNO) at tunable rates in physiological media. The approach involves converting a spontaneously HNO/NO-generating ion to a caged (prodrug) form that is essentially stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f53fabc687fa069c79f17fd5e34475b
https://doi.org/10.1016/j.niox.2013.10.003
https://doi.org/10.1016/j.niox.2013.10.003
Autor:
Nazareno Paolocci, Julie L. Heinecke, Katrina M. Miranda, Carlos A. Velázquez-Martínez, Ryan J. Holland, Gaurav Bharadwaj, Viviane Caceres, Lisa A. Ridnour, Sa Shi, Regina Celia Spadari-Bratfisch, Robert Y.S. Cheng, David A. Wink, Debashree Basudhar, Sarthak Jain
Publikováno v:
Journal of Medicinal Chemistry. 56:7804-7820
Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity, but they may increase the risk of myocardial infarction w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185d4c44b22bb9a1ddd83b9fb48699c6
https://doi.org/10.1021/jm400196q
https://doi.org/10.1021/jm400196q
Publikováno v:
The Journal of Physical Chemistry A. 117:6671-6677
Amine-based diazeniumdiolates (NONOates) have garnered widespread use as nitric oxide (NO) donors, and their potential for nitroxyl (HNO) release has more recently been realized. While NO release rates can vary significantly with the type of amine, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24c0e4403fdc650e7b98697d6fd81a1
https://doi.org/10.1021/jp404589p
https://doi.org/10.1021/jp404589p
Autor:
Larry K. Keefer, Luis G. Rodriguez, Ryan J. Holland, Lucy M. Anderson, Y.-S. Robert Cheng, Joseph E. Saavedra, Anna E. Maciag
Publikováno v:
Redox Biology
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)
JS-K is a nitric oxide (NO)-releasing prodrug of the O2-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in vitro and in vivo. The current study of the metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba49a124fdf9df94aa20894824daedee
http://europepmc.org/articles/PMC3757670
http://europepmc.org/articles/PMC3757670
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163821 (2016)
PLoS ONE, Vol 11, Iss 9, p e0163821 (2016)
Dietary isothiocyanates abundant as glucosinolate precursors in many edible cruciferous vegetables are effective for prevention of cancer in chemically-induced and transgenic rodent models. Some of these agents, including phenethyl isothiocyanate (PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c916e20de28bb66bee8d7bba732e7b58
http://europepmc.org/articles/PMC5042466
http://europepmc.org/articles/PMC5042466
Autor:
Lei Shi, Ryan J. Holland, Robert K. Prud'homme, Joseph E. Saavedra, Anna E. Maciag, Varun Kumar, Larry K. Keefer, Harinath Chakrapani
Publikováno v:
Chemical Research in Toxicology. 25:2670-2677
Attachment of glutathione (GSH) to cysteine residues in proteins (S-glutathionylation) is a reversible post-translational modification that can profoundly alter protein structure and function. Often serving in a protective role, for example, by tempo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384792c2a1ce62ee9d039318bb897e11
https://doi.org/10.1021/tx3003142
https://doi.org/10.1021/tx3003142
Autor:
Harinath Chakrapani, Larry K. Keefer, Anna E. Maciag, Paul J. Shami, Ryan J. Holland, Joseph E. Saavedra
Publikováno v:
Forum on Immunopathological Diseases and Therapeutics. 3:91-95
Promising drug candidates of the diazeniumdiolate (NONOate) chemical family include several types of thiol modification among their mechanisms of action: 1) drugs designed to release nitric oxide (NO) on reaction with the thiol group of glutathione (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456009aab884cdedd33bd5616b4993b6
https://doi.org/10.1615/forumimmundisther.2012006334
https://doi.org/10.1615/forumimmundisther.2012006334
Autor:
James C. Fishbein, Ryan J. Holland
Publikováno v:
Antioxidants & Redox Signaling. 13:1749-1761
The protein Kelch-like ECH-associated protein 1 (Keap1) is a cysteine-rich regulatory and scaffold protein. Human Keap1 contains 27 cysteines. Some of these cysteines are believed to mediate derepression of the transcription factor nuclear factor (er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16fec6f939d34c1b3aae0810d5614c8
https://doi.org/10.1089/ars.2010.3273
https://doi.org/10.1089/ars.2010.3273