Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ryan J. Eller"'
Autor:
Seppe Goovaerts, Hanne Hoskens, Ryan J. Eller, Noah Herrick, Anthony M. Musolf, Cristina M. Justice, Meng Yuan, Sahin Naqvi, Myoung Keun Lee, Dirk Vandermeulen, Heather L. Szabo-Rogers, Paul A. Romitti, Simeon A. Boyadjiev, Mary L. Marazita, John R. Shaffer, Mark D. Shriver, Joanna Wysocka, Susan Walsh, Seth M. Weinberg, Peter Claes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The cranial vault in humans is highly variable, clinically relevant, and heritable, yet its genetic architecture remains poorly understood. Here, we conduct a joint multi-ancestry and admixed multivariate genome-wide association study on 3D
Externí odkaz:
https://doaj.org/article/69a3d3cc3f27415f9870d75eead756a6
Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background Genome imputation, admixture resolution and genome-wide association analyses are timely and computationally intensive processes with many composite and requisite steps. Analysis time increases further when building and installing
Externí odkaz:
https://doaj.org/article/397c25b060b34c6399ff22603b453b48
Autor:
Karlijne Indencleef, Hanne Hoskens, Myoung Keun Lee, Julie D. White, Chenxing Liu, Ryan J. Eller, Sahin Naqvi, George L. Wehby, Lina M. Moreno Uribe, Jacqueline T. Hecht, Ross E. Long, Kaare Christensen, Frederic W. Deleyiannis, Susan Walsh, Mark D. Shriver, Stephen Richmond, Joanna Wysocka, Hilde Peeters, John R. Shaffer, Mary L. Marazita, Greet Hens, Seth M. Weinberg, Peter Claes
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate (NSCL/P) show distinctive facial features. The presence of this facial endophenotype is potentially an expression of underlying genetic susceptibility to NS
Externí odkaz:
https://doaj.org/article/b44ba2f0b8b04c2ab9758cb8e66b3391
Autor:
Seppe Goovaerts, Hanne Hoskens, Ryan J Eller, Noah Herrick, Anthony M Musolf, Cristina M Justice, Meng Yuan, Sahin Naqvi, Myoung Keun Lee, Dirk Vandermeulen, Heather L Szabo-Rogers, Paul A Romitti, Simeon A Boyadjiev, Mary L Marazita, John R Shaffer, Mark D Shriver, Joanna Wysocka, Susan Walsh, Seth M Weinberg, Peter Claes
The cranial vault – the portion of the skull surrounding the brain and cerebellum – is highly variable, clinically relevant, and heritable, yet its genetic architecture remains poorly understood. Here, we conducted a joint multi-ancestry and admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9124a7e45a6950e172d7d1562b29c9e8
https://doi.org/10.1101/2022.12.01.518684
https://doi.org/10.1101/2022.12.01.518684
Autor:
Ellen E. Quillen, Eleanor Feingold, Jiarui Li, Greet Hens, John R. Shaffer, Karlijne Indencleef, Jasmien Roosenboom, Susan Walsh, Mark D. Shriver, Mary L. Marazita, Ryan J. Eller, Julie D. White, Heather L. Norton, Peter Claes, Hanne Hoskens, Sahin Naqvi, Hilde Peeters, Stephen Richmond, Myoung Keun Lee, Joanna Wysocka, Seth M. Weinberg, Jaaved Mohammed, Tomek Swigut
Publikováno v:
Nature genetics
The human face is complex and multipartite, and characterization of its genetic architecture remains challenging. Using a multivariate genome-wide association study meta-analysis of 8,246 European individuals, we identified 203 genome-wide-significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23636ac6011467c7da9d80391994efd
http://europepmc.org/articles/PMC7796995
http://europepmc.org/articles/PMC7796995
Autor:
Susan Walsh, John R. Shaffer, Karlijne Indencleef, Sahin Naqvi, Mark D. Shriver, Dongjing Liu, Jaaved Mohammed, Chenxing Liu, Jiarui Li, Peter Claes, Tomek Swigut, Julie D. White, Hanne Hoskens, Richard A. Spritz, Ryan J. Eller, Benedikt Hallgrímsson, Mary L. Marazita, Eleanor Feingold, Joanna Wysocka, Stephen Richmond, Seth M. Weinberg, Myoung Keun Lee, Harold Matthews, Mange Manyama
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009695 (2021)
PLoS Genetics
PLoS Genetics
Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different aspects of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61396bafd599ff69f23c9a7b9dbac43d
https://lirias.kuleuven.be/handle/123456789/679258
https://lirias.kuleuven.be/handle/123456789/679258
Autor:
Stephen Richmond, Stefan Sunaert, Seth M. Weinberg, Ryan J. Eller, John R. Shaffer, Ahmed Radwan, James C. Thompson, Susan Walsh, Yoeri Sleyp, Jeffrey P. Spence, Rose Bruffaerts, Jonathan K. Pritchard, Karlijne Indencleef, Joanna Wysocka, Mark D. Shriver, Peter Claes, Hanne Hoskens, Sahin Naqvi, Hilde Peeters
Publikováno v:
Nature genetics. 53(6)
Evidence from model organisms and clinical genetics suggests coordination between the developing brain and face, but the role of this link in common genetic variation remains unknown. We performed a multivariate genome-wide association study of corti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b10771361f174de76d50ff65c67765
https://pubmed.ncbi.nlm.nih.gov/33888909
https://pubmed.ncbi.nlm.nih.gov/33888909
Autor:
Ahmed Radwan, James C. Thompson, Susan Walsh, Karlijne Indencleef, Stephen Richmond, Yoeri Sleyp, Mark D. Shriver, Jeffrey P. Spence, Joanna Wysocka, Rose Bruffaerts, Seth M. Weinberg, Stefan Sunaert, Sahin Naqvi, John R. Shaffer, Hilde Peeters, Jonathan K. Pritchard, Ryan J. Eller, Hanne Hoskens, Peter Claes
Evidence from both model organisms and clinical genetics suggests close coordination between the developing brain and face1–8, but it remains unknown whether this developmental link extends to genetic variation that drives normal-range diversity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1db2af89df3f08fad9229b78bf73ce
https://doi.org/10.1101/2020.08.29.269258
https://doi.org/10.1101/2020.08.29.269258
Autor:
Noah Herrick, Hanne Hoskens, Jiarui Li, Ryan J. Eller, Karlijne Indencleef, Arslan A. Zaidi, Tomás González Zarzar, Susan Walsh, Mark D. Shriver, Peter Claes, Julie D. White, Nele Nauwelaers, Torsten Günther, Mattias Jakobsson, Harry Matthews, Emma Svensson, Kristel Van Steen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis of population structure and genomic ancestry can yield insights in terms of modern and ancient populations, allowing us to address q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea636437b398aacc98568d81ecb18d6
https://lirias.kuleuven.be/handle/123456789/657438
https://lirias.kuleuven.be/handle/123456789/657438
Autor:
Ryan J. Eller, Jasmien Roosenboom, Seth M. Weinberg, John R. Shaffer, Julie D. White, Joanna Wysocka, Jiarui Li, Mary L. Marazita, Eleanor Feingold, Heather L. Norton, Greet Hens, Ellen E. Quillen, Stephen Richmond, Myoung Keun Lee, Karlijne Indencleef, Peter Claes, Mark D. Shriver, Sahin Naqvi, Hilde Peeters, Jaaved Mohammed, Tomek Swigut, Susan Walsh
The human face is complex and multipartite, and characterization of its genetic architecture remains intriguingly challenging. Applying GWAS to multivariate shape phenotypes, we identified 203 genomic regions associated with normal-range facial varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c756f6b7a11170c07cfdbcf6c3e1f59a