Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryan J. Brown"'
Autor:
Moujtaba Y. Kasmani, Paytsar Topchyan, Ashley K. Brown, Ryan J. Brown, Xiaopeng Wu, Yao Chen, Achia Khatun, Donia Alson, Yue Wu, Robert Burns, Chien-Wei Lin, Matthew R. Kudek, Jie Sun, Weiguo Cui
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Influenza virus infection causes increased morbidity and mortality in the elderly. Aging impairs the immune response to influenza, both intrinsically and because of altered interactions with endothelial and pulmonary epithelial cells. To cha
Externí odkaz:
https://doaj.org/article/3316c2e4f76a4dd280e12a2c2ed09272
Autor:
Alexander A. Pieper, Luke M. Zangl, Dan V. Speigelman, Arika S. Feils, Anna Hoefges, Justin C. Jagodinsky, Mildred A. Felder, Noah W. Tsarovsky, Ian S. Arthur, Ryan J. Brown, Jen Birstler, Trang Le, Peter M. Carlson, Amber M. Bates, Jacquelyn A. Hank, Alexander L. Rakhmilevich, Amy K. Erbe, Paul M. Sondel, Ravi B. Patel, Zachary S. Morris
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
IntroductionCombining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective in situ vaccine in some tumor models, including the A20 lymphoma model. Immunologically “cold” tumors, which are typically
Externí odkaz:
https://doaj.org/article/3c1a8a46c1f247d4b0ac7ee7662a9e57
Autor:
Amber M. Bates, Ryan J. Brown, Alexander A. Pieper, Luke M. Zangl, Ian Arthur, Peter M. Carlson, Trang Le, Gustavo A. Sosa, Paul A. Clark, Raghava N. Sriramaneni, KyungMann Kim, Ravi B. Patel, Zachary S. Morris
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Surgical resection or hypo-fractionated radiation therapy (RT) in early-stage non-small cell lung cancer (NSCLC) achieves local tumor control, but metastatic relapse remains a challenge. We hypothesized that immunotherapy with anti-CTLA-4 and bempega
Externí odkaz:
https://doaj.org/article/a1b857248b16405ead2ae0e0249723e4
Autor:
Zachary S. Morris, Trang T. Le, Ian Marsh, Won Jong Jin, Peter M. Carlson, Raghava N. Sriramaneni, Jonathan W. Engle, Luke M. Zangl, Justin C. Jagodinsky, Amber M. Bates, Todd E. Barnhart, Joseph Grudzinski, Ian S. Arthur, Ravi Patel, Ryan J. Brown, Erin J. Nystuen, Reinier Hernandez, Ishan Chakravarty, Jamey P. Weichert, KyungMann Kim, Bryan Bednarz, Eduardo Aluicio-Sarduy, Caroline Kerr, Sarah E. Emma
Publikováno v:
Theranostics
Rationale: Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 interferon (IFN1) response mediated via stimulator of interferon genes (STING),
Publikováno v:
SNE Simulation Notes Europe. 28:141-148
Autor:
Ryan J. Brown, Ian S. Arthur, Erin J. Nystuen, Ravi Patel, Luke M. Zangl, Ishan Chakravarty, Zachary S. Morris, Ian Marsh, Joseph Grudzinski, KyungMann Kim, Justin C. Jagodinsky, Amber M. Bates, Jamey P. Weichert, Bryan Bednarz, Todd E. Barnhart, Eduardo Aluicio-Sarduy, Trang T. Le, Won Jong Jin, Peter M. Carlson, Sarah E. Emma, Caroline Kerr, Jonathan W. Engle, Reinier Hernandez
Publikováno v:
Cancer Research. 81:3060-3060
Background: Radiation (RT) activates a type 1 interferon (IFN1) response and this is critical to the effect of RT in priming a response to immune checkpoint blockade (ie anti-CTLA4). However, little is known about the time course of this effect. Clin
Autor:
Zachary S. Morris, Jamey P. Weichert, Christian M. Capitini, Anatoly Pinchuk, Joseph Grudzinski, Reinier Hernandez, Eduardo Aluicio-Sarduy, Jonathan W. Engle, Christopher D. Zahm, Paul M. Sondel, Kirsti L. Walker, Ryan J. Brown, Christopher Massey, Ravi Patel, Ariana N. Bitton
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology
Communications Biology
Finding improved therapeutic strategies against T-cell Non-Hodgkin’s Lymphoma (NHL) remains an unmet clinical need. We implemented a theranostic approach employing a tumor-targeting alkylphosphocholine (NM600) radiolabeled with 86Y for positron emi
Autor:
Zachary S. Morris, Luke M. Zangl, Ian Marsh, Peter M. Carlson, Juliana S. Castillo, Reinier Hernandez, Jamey P. Weichert, Bryan Bednarz, Wonjon J. Jin, Joseph Grudzinski, Ishan Chakravarty, Justin C. Jagodinsky, Ryan J. Brown, Ian S. Arthur, Ravi Patel
Publikováno v:
Cancer Research. 80:477-477
Background: Radiation (RT) activates a type 1 interferon (IFN-1) response and, in preclinical studies, this is critical to the effect of RT in priming a response to immune checkpoint blockade. Recent studies report the impact of external beam radioth
Autor:
Juliana S. Castillo, Alex Pieper, Peter M. Carlson, Luke M. Zangl, Paul M. Sondel, Zach S. Morris, Ryan J. Brown, Alexander L. Rakhmilevich, Ian S. Arthur, Ravi Patel
Publikováno v:
Cancer Research. 80:4455-4455
Purpose: Surgical resection or stereotactic ablative radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) have local control rates of 90% or higher. Current treatment paradigms effectively control primary tumor sites, but distan
Autor:
Abigail A Jaquish, Zachary S. Morris, Yuyuan Wang, Ian S. Arthur, Ben Ma, Ryan J. Brown, KyungMann Kim, Ravi Patel, Shaoqin Gong, Peter M. Carlson, Luke M. Zangl, Mingzhou Ye, Xing Wang, Ruosen Xie, Raghava N. Sriramaneni
Publikováno v:
Adv Mater
Neoantigens induced by random mutations and specific to an individual’s cancer are the most important tumor antigens recognized by T cells. Among immunologically “cold” tumors, limited recognition of tumor neoantigens results in the absence of