Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ryan J. Bourgo"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Chromatin architecture is a key regulator of transcriptional processes, however current methods to investigate it have technical limitations. Here, the authors describe a novel chromatin capture technique, CATCH, which can be used to identify and cha
Externí odkaz:
https://doaj.org/article/d9d922e6f2af4de89e92707b4595c4a8
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64091 (2013)
The study of the pathogenesis of breast cancer is challenged by the long time-course of the disease process and the multi-factorial nature of generating oncogenic insults. The characterization of the longitudinal pathogenesis of malignant transformat
Externí odkaz:
https://doaj.org/article/ae34845be50548d49c3beb652af614f4
Autor:
Uthra Balaji, Erik S. Knudsen, Agnieszka K. Witkiewicz, Ryan J. Bourgo, Jack Hutcheson, Adam Ertel
Publikováno v:
Hepatology. 60:1231-1240
Cancers mediated by viral etiology must exhibit deregulated cellular proliferation and evade immune recognition. The role of the retinoblastoma tumor suppressor (RB) pathway, which is lost at relatively high frequency in hepatocellular carcinoma (HCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09e3d7ad308a4a8b5393257292a4990
https://doi.org/10.1002/hep.27217
https://doi.org/10.1002/hep.27217
Autor:
Allison L. Zarnke, Ganesh V. Raj, Wayne D. Tilley, Geoffrey L. Greene, Anna G. Dembo, Ryan J. Bourgo, Ya Fang Chang, Marianne E. Greene, Gerard A. Tarulli, Hari Singhal, Shihong Ma, Theresa E. Hickey, Muriel Laine
Publikováno v:
Science Advances
Individual and concerted actions of ER and PR highlight the prognostic and therapeutic value of PR in ER+/PR+ breast cancers.
The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controve
The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a27b67343ac9c0c8a0ee929180b13f
https://doi.org/10.1126/sciadv.1501924
https://doi.org/10.1126/sciadv.1501924
Autor:
A. Kathleen McClendon, Agnieszka K. Witkiewicz, Ryan J. Bourgo, Ludwig Wilkens, Adam Ertel, Jean Y. J. Wang, Chellappagounder Thangavel, Jacqueline Bergseid, Erik S. Knudsen
Publikováno v:
Molecular Cell. 43(4):663-672
The LXCXE peptide motif facilitates interaction between the RB tumor suppressor and a large number of cellular proteins that are expected to impinge on diverse biological processes. In vitro and in vivo analyses demonstrated that LXCXE binding functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e543e2e976b72943c3427dc5d64db16e
Autor:
Pierre Chambon, Charles W. M. Roberts, Hasan Siddiqui, Moshe Yaniv, Christian Muchardt, Erik S. Knudsen, David A. Solomon, Ryan J. Bourgo, Daniel Metzger, Sejal R. Fox, Courtney G. Sansam
Publikováno v:
Molecular Biology of the Cell. 20:3192-3199
Switch (SWI)/sucrose nonfermentable (SNF) is an evolutionarily conserved complex with ATPase function, capable of regulating nucleosome position to alter transcriptional programs within the cell. It is known that the SWI/SNF complex is responsible fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6d5a05856ae3f4dbef8ba1711adf08
https://doi.org/10.1091/mbc.e08-12-1224
https://doi.org/10.1091/mbc.e08-12-1224
Publikováno v:
Molecular Carcinogenesis. 48:45-55
High-risk human papilloma virus (HPV) encodes two oncoproteins, E6 and E7, which are vital to viral replication and contribute to the development of cervical cancer. HPV16 E7 can target over 20 cellular proteins, but is best known for inactivating th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93343c045bbb2e471c10fac145dfffb0
https://doi.org/10.1002/mc.20456
https://doi.org/10.1002/mc.20456
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Here we describe a sensitive and novel method of identifying endogenous DNA–DNA interactions. Capture of Associated Targets on CHromatin (CATCH) uses efficient capture and enrichment of specific genomic loci of interest through hybridization and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715d5d9d2f6565b8eb7e3efcb8cc9a78
https://pubmed.ncbi.nlm.nih.gov/27634217
https://pubmed.ncbi.nlm.nih.gov/27634217
Introduction The mitotic cell cycle consists of four discrete phases that comprise the ordered processes required for the accurate division and partition of the genetic material into viable daughter cells (Figure 38.1). These processes are tightly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5e024ed2ea6f703ee903faa6b0219ae
https://doi.org/10.1017/cbo9781139046947.039
https://doi.org/10.1017/cbo9781139046947.039
Publikováno v:
Molecular Biology of the Cell
The retinoblastoma tumor suppressor (RB) is functionally inactivated at high frequency in nearly all tumor types. Herein the acute deletion of RB in the liver reveals an immediate and profound dysregulation of spatiotemporal coordination in cell-cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16393982a29e67d485a0b406945b5dd
https://pubmed.ncbi.nlm.nih.gov/21289097
https://pubmed.ncbi.nlm.nih.gov/21289097