Výsledky vyhledávání - "Ryan J. Bohlender"

Akademický článek

A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk

Publikováno v: HGG Advances, Vol 3, Iss 1, Pp 100078- (2022)

Summary: Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a modest proportion of the heritable risk of pancreatic c

Externí odkaz: https://doaj.org/article/35919610e3b94c3faf02f24e0e28d715

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Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate

Autor: Yao Yu, Rolando Alvarado, Lauren E Petty, Ryan J Bohlender, Douglas M Shaw, Jennifer E Below, Nada Bejar, Oscar E Ruiz, Bhavna Tandon, George T Eisenhoffer, Daniel L Kiss, Chad D Huff, Ariadne Letra, Jacqueline T Hecht

Publikováno v: Hum Mol Genet

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common, severe craniofacial malformation that imposes significant medical, psychosocial and financial burdens. NSCL/P is a multifactorial disorder with genetic and environmental facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea418e0c8dd33434bb4e30a4442976
https://doi.org/10.1093/hmg/ddac037

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Akademický článek

Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon

Autor: Anna I Vickrey, Rebecca Bruders, Zev Kronenberg, Emma Mackey, Ryan J Bohlender, Emily T Maclary, Raquel Maynez, Edward J Osborne, Kevin P Johnson, Chad D Huff, Mark Yandell, Michael D Shapiro

Publikováno v: eLife, Vol 7 (2018)

Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons (Columba livia) are fundamentally one of four color pattern phenotypes, in decreasing ord

Externí odkaz: https://doaj.org/article/3d20fa45e26f4177ae484b3744fd14b1

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Host genetic effects in pneumonia

Autor: Lisa Bastarache, Kari E. North, Xue Zhong, Lauren E. Petty, Hannah G. Polikowsky, Ruth J. F. Loos, Michael Preuss, Nancy J. Cox, Megan M. Shuey, Chad D. Huff, Douglas M. Shaw, Misa Graff, Daeeun Kim, Julie A. Bastarache, Victoria L. Buchanan, Jennifer E. Below, Hung-Hsin Chen, Ryan J. Bohlender

Publikováno v: American Journal of Human Genetics
The American Journal of Human Genetics

Summary Given the coronavirus disease 2019 (COVID-19) pandemic, investigations into host susceptibility to infectious diseases and downstream sequelae have never been more relevant. Pneumonia is a lung disease that can cause respiratory failure and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a110d1acdd01b87c427d026b94c669
http://europepmc.org/articles/PMC7820802

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Abstract 13286: Finding the Missing Heritability of Serum Lipids: Leveraging the Relatedness in a Large-scale Biobank

Autor: Ryan J. Bohlender, Jennifer E. Below, Lauren E. Petty, Hung-Hsin Chen, Quinn S. Wells, Chad D. Huff

Publikováno v: Circulation. 142

Introduction: High prevalence of dyslipidemia in the United States results in elevated risk of cardiovascular disease. Although the high heritability of serum lipids has motivated many genome-wide association studies (GWAS), much of the heritability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d33d12cd923df39e7413e66f62755b60
https://doi.org/10.1161/circ.142.suppl_3.13286

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Early history of Neanderthals and Denisovans

Autor: Chad D. Huff, Alan R. Rogers, Ryan J. Bohlender

Publikováno v: Proceedings of the National Academy of Sciences. 114:9859-9863

Significance Neanderthals and Denisovans were human populations that separated from the modern lineage early in the Middle Pleistocene. Many modern humans carry DNA derived from these archaic populations by interbreeding during the Late Pleistocene.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::959494304b9eb58f39e184bf128bfa16
https://doi.org/10.1073/pnas.1706426114

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