Výsledky vyhledávání - "Ryan J. Andrews"

Akademický článek

ScanFold 2.0: a rapid approach for identifying potential structured RNA targets in genomes and transcriptomes

Autor: Ryan J. Andrews, Warren B. Rouse, Collin A. O’Leary, Nicholas J. Booher, Walter N. Moss

Publikováno v: PeerJ, Vol 10, p e14361 (2022)

A major limiting factor in target discovery for both basic research and therapeutic intervention is the identification of structural and/or functional RNA elements in genomes and transcriptomes. This was the impetus for the original ScanFold algorith

Externí odkaz: https://doaj.org/article/974e03753a5b44e8ab290d91009c1eca

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Akademický článek

Targeting the SARS-CoV‑2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Autor: Hafeez S. Haniff, Yuquan Tong, Xiaohui Liu, Jonathan L. Chen, Blessy M. Suresh, Ryan J. Andrews, Jake M. Peterson, Collin A. O’Leary, Raphael I. Benhamou, Walter N. Moss, Matthew D. Disney

Publikováno v: ACS Central Science, Vol 6, Iss 10, Pp 1713-1721 (2020)

Externí odkaz: https://doaj.org/article/7d0b00c666094ff5a93e78d8eb1ef1ed

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Akademický článek

A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs

Autor: Ryan J. Andrews, Collin A. O’Leary, Walter N. Moss

Publikováno v: PeerJ, Vol 8, p e9882 (2020)

There are nine herpesviruses known to infect humans, of which Epstein–Barr virus (EBV) is the most widely distributed (>90% of adults infected). This ubiquitous virus is implicated in a variety of cancers and autoimmune diseases. Previous analyses

Externí odkaz: https://doaj.org/article/c5151111eb63445689b9c5aee2396613

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Akademický článek

ScanFold: an approach for genome-wide discovery of local RNA structural elements—applications to Zika virus and HIV

Autor: Ryan J. Andrews, Julien Roche, Walter N. Moss

Publikováno v: PeerJ, Vol 6, p e6136 (2018)

In addition to encoding RNA primary structures, genomes also encode RNA secondary and tertiary structures that play roles in gene regulation and, in the case of RNA viruses, genome replication. Methods for the identification of functional RNA structu

Externí odkaz: https://doaj.org/article/7f6d2da29b04437aba50fc7aac184bd6

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Akademický článek

Analyses of human cancer driver genes uncovers evolutionarily conserved RNA structural elements involved in posttranscriptional control.

Autor: Van S Tompkins, Warren B Rouse, Collin A O'Leary, Ryan J Andrews, Walter N Moss

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0264025 (2022)

Experimental breakthroughs have provided unprecedented insights into the genes involved in cancer. The identification of such cancer driver genes is a major step in gaining a fuller understanding of oncogenesis and provides novel lists of potential t

Externí odkaz: https://doaj.org/article/3281e89187ee4696b895142722304d2b

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Akademický článek

Plasmodium falciparum translational machinery condones polyadenosine repeats

Autor: Slavica Pavlovic Djuranovic, Jessey Erath, Ryan J Andrews, Peter O Bayguinov, Joyce J Chung, Douglas L Chalker, James AJ Fitzpatrick, Walter N Moss, Pawel Szczesny, Sergej Djuranovic

Publikováno v: eLife, Vol 9 (2020)

Plasmodium falciparum is a causative agent of human malaria. Sixty percent of mRNAs from its extremely AT-rich (81%) genome harbor long polyadenosine (polyA) runs within their ORFs, distinguishing the parasite from its hosts and other sequenced organ

Externí odkaz: https://doaj.org/article/d37acee87930453b87d97c561d9b9e5f

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9-BBN and chloride catalyzed reduction of chlorophosphines to phosphines and diphosphines

Autor: Iris Elser, Ryan J. Andrews, Douglas W. Stephan

Publikováno v: Chemical Communications. 58:1740-1743

Commercially available 9-BBN and [Et4N]Cl catalyze reduction of chlorophosphines (R2PCl) with PhSiH3 to provide phosphines (R2PH) and diphosphines (P2R4).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14622cb8c18bbac1ab5c023ec22f9f02
https://doi.org/10.1039/d1cc06439h

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Synthesis and reactivity of donor stabilized thionylium (SO2+) dications

Autor: Ryan J. Andrews, John R. De Backere, Douglas W. Stephan

Publikováno v: Chemical Communications. 58:11434-11437

Mono-, di-, and tridentate base-stabilized thionylium (SO2+) dications synthesized from SOCl2 demonstrate Lewis acidicity, activate C–F bonds of fluoroalkanes and effect O2− capture evolving SO2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eacfe47d37ab88a986bf8ce006e7edb8
https://doi.org/10.1039/d2cc04129d

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Multiresponsive Cyclometalated Crown Ether Bearing a Platinum(II) Metal Center

Autor: Ryan J. Andrews, Mark J. MacLachlan, Maria T. Cano, Veronica Carta, Brian O. Patrick, Miguel A. Soto

Publikováno v: Inorganic Chemistry. 61:2999-3006

Multiresponsive materials can adapt to numerous changes in their local environment, which makes them highly valuable for various applications. Although nanostructured and polymeric multiresponsive materials are plentiful, small-molecule analogues are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ea793eace1439ad5f1e250c0e4c8cd
https://doi.org/10.1021/acs.inorgchem.1c03178

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