Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Ryan J Mailloux"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192801 (2018)
Protein S-glutathionylation is a reversible redox modification that regulates mitochondrial metabolism and reactive oxygen species (ROS) production in liver and cardiac tissue. However, whether or not it controls ROS release from skeletal muscle mito
Externí odkaz:
https://doaj.org/article/33d2963b00c7438780ea701cab93455d
Autor:
Ryan J Mailloux, Maria Florian, Qixuan Chen, Jin Yan, Ivan Petrov, Melanie C Coughlan, Mahemuti Laziyan, Don Caldwell, Michelle Lalande, Dominique Patry, Claude Gagnon, Kurtis Sarafin, Jocelyn Truong, Hing Man Chan, Nimal Ratnayake, Nanqin Li, William G Willmore, Xiaolei Jin
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106832 (2014)
Non-alcoholic fatty liver disease (NAFLD), defined by the American Liver Society as the buildup of extra fat in liver cells that is not caused by alcohol, is the most common liver disease in North America. Obesity and type 2 diabetes are viewed as th
Externí odkaz:
https://doaj.org/article/3b3919fd216a41cab30b526aaa76c70c
Autor:
Céline Aguer, Daniela Gambarotta, Ryan J Mailloux, Cynthia Moffat, Robert Dent, Ruth McPherson, Mary-Ellen Harper
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28536 (2011)
Human primary myotubes are highly glycolytic when cultured in high glucose medium rendering it difficult to study mitochondrial dysfunction. Galactose is known to enhance mitochondrial metabolism and could be an excellent model to study mitochondrial
Externí odkaz:
https://doaj.org/article/ffde2c8b5fb94fbcb7060372b779f45a
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13289 (2010)
Uncoupling protein-2 (UCP2) is known to suppress mitochondrial reactive oxygen species (ROS) production and is employed by drug-resistant cancer cells to mitigate oxidative stress. Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subli
Externí odkaz:
https://doaj.org/article/07f8a33ed08441058fced4872ff34850
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7344 (2009)
Although the tricarboxylic acid (TCA) cycle is essential in almost all aerobic organisms, its precise modulation and integration in global cellular metabolism is not fully understood. Here, we report on an alternative TCA cycle uniquely aimed at gene
Externí odkaz:
https://doaj.org/article/7cdd4aef664f455fa22871148838b0f0
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2682 (2008)
The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is pivotal to the cellular anti-oxidative defence strategies in most organisms. Although its production mediated by different enzyme systems has been relatively well-studied, metabolic n
Externí odkaz:
https://doaj.org/article/b7ef52daf39240bb8fad2211912ff383
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1550 (2008)
Lactate has long been regarded as an end product of anaerobic energy production and its fate in cerebral metabolism has not been precisely delineated. In this report, we demonstrate, for the first time, the ability of a human astrocytic cell line (CC
Externí odkaz:
https://doaj.org/article/7527ad9ffca148b1aca4a8ea09db6411
Autor:
Ryan J Mailloux, Robin Bériault, Joseph Lemire, Ranji Singh, Daniel R Chénier, Robert D Hamel, Vasu D Appanna
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e690 (2007)
The tricarboxylic acid (TCA) cycle is an essential metabolic network in all oxidative organisms and provides precursors for anabolic processes and reducing factors (NADH and FADH(2)) that drive the generation of energy. Here, we show that this metabo
Externí odkaz:
https://doaj.org/article/862f5883fbae4185ab36ac2a4b7eafdb
Autor:
Ryan J. Mailloux
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103155- (2024)
The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate dehydrogenase (KGDHc), branched-chain keto acid dehydrogenase (BCKDHc), and 2-oxoadipate dehydro
Externí odkaz:
https://doaj.org/article/25ae446c04464d1684901c73e213c109
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 674 (2023)
Although circadian biorhythms of mitochondria and cells are highly conserved and crucial for the well-being of complex animals, there is a paucity of studies on the reciprocal interactions between oxidative stress, redox modifications, metabolism, th
Externí odkaz:
https://doaj.org/article/8a70eda719964acfb6e276e4f9c0452c