Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ryan J Hansen"'
Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.
Autor:
Joseph W Briggs, Ling Ren, Kristi R Chakrabarti, Yien Che Tsai, Allan M Weissman, Ryan J Hansen, Daniel L Gustafson, Yousuf A Khan, Jonathan D Dinman, Chand Khanna
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185089 (2017)
Activation of the unfolded protein response (UPR) in eukaryotic cells represents an evolutionarily conserved response to physiological stress. Here, we report that the mTOR inhibitors rapamycin (sirolimus) and structurally related temsirolimus are ca
Externí odkaz:
https://doaj.org/article/21191385288e488bb0ace408ca335cc3
Autor:
Haineng Xu, Sarah B. Gitto, Gwo-Yaw Ho, Sergey Medvedev, Kristy Shield-Artin, Hyoung Kim, Sally Beard, Yasuto Kinose, Xiaolei Wang, Holly E. Barker, Gayanie Ratnayake, Wei-Ting Hwang, Ryan J. Hansen, Bryan Strouse, Snezana Milutinovic, Christian Hassig, Matthew J. Wakefield, Cassandra J. Vandenberg, Clare L. Scott, Fiona Simpkins
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109978- (2024)
Summary: High-grade serous ovarian cancers (HGSOCs) with homologous recombination deficiency (HRD) are initially responsive to poly (ADP-ribose) polymerase inhibitors (PARPi), but resistance ultimately emerges. HGSOC with CCNE1 amplification (CCNE1am
Externí odkaz:
https://doaj.org/article/1ed5cdda17844d2e8fc282a3b801056b
Autor:
Emilee C. Venn, Alex J. Barnes, Ryan J. Hansen, Pedro L. Boscan, David C. Twedt, Lauren A. Sullivan
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 34, Iss 2, Pp 691-699 (2020)
Abstract Background Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D‐lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid‐base status
Externí odkaz:
https://doaj.org/article/44e663a3e8c846f6b8a20ff77af8f7aa
Autor:
Julie S, Moyers, Ryan J, Hansen, Jonathan W, Day, Craig D, Dickinson, Chen, Zhang, Xiaoping, Ruan, Liyun, Ding, Robin M, Brown, Hana E, Baker, John M, Beals
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:346-355
The benefit of once-weekly basal insulin is less frequent dosing, which has the potential to reduce the barrier to injection therapy and impact patient activation, adherence and compliance, quality of life, and outcomes. Basal Insulin Fc (BIF, LY3209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c435ab7265da35669d2b5357f9bdda
https://doi.org/10.1124/jpet.122.001105
https://doi.org/10.1124/jpet.122.001105
Autor:
Chand Khanna, Peter C. Scacheri, Timothy M. Fan, Ming Zhou, Daniel L. Gustafson, Ryan J. Hansen, Timothy J. Waybright, Ling Ren, Michael M. Lizardo, Allyson Koyen, Arnulfo Mendoza, James J. Morrow
Legends for Supplementary Tables and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942fcd3e3a674bad82006e0fc7edd911
https://doi.org/10.1158/1078-0432.22468887
https://doi.org/10.1158/1078-0432.22468887
Autor:
Chand Khanna, Peter C. Scacheri, Timothy M. Fan, Ming Zhou, Daniel L. Gustafson, Ryan J. Hansen, Timothy J. Waybright, Ling Ren, Michael M. Lizardo, Allyson Koyen, Arnulfo Mendoza, James J. Morrow
Purpose: To successfully metastasize, tumor cells must respond appropriately to biological stressors encountered during metastatic progression. We sought to test the hypothesis that enhanced efficiency of mRNA translation during periods of metastatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb01450fc974ab0d0990de07585b753
https://doi.org/10.1158/1078-0432.c.6527085.v1
https://doi.org/10.1158/1078-0432.c.6527085.v1
Autor:
S. Gail Eckhardt, Robert A. Winn, Wells A. Messersmith, James V. DeGregori, Daniel L. Gustafson, Kelly L. McPhillips, Timothy P. Newton, Heather M. Selby, Lindsey N. Micel, Jihye Kim, Ryan J. Hansen, Martine C. McManus, Peter J. Klauck, John J. Arcaroli, Mark A. Gregory, Aik Choon Tan, Todd M. Pitts, John J. Tentler, Anna Spreafico
Supplementary Methods - PDF file 124K, Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abee7e1eb2c8d253617150600e843cd
https://doi.org/10.1158/1078-0432.22446339
https://doi.org/10.1158/1078-0432.22446339
Autor:
Chand Khanna, Peter C. Scacheri, Timothy M. Fan, Ming Zhou, Daniel L. Gustafson, Ryan J. Hansen, Timothy J. Waybright, Ling Ren, Michael M. Lizardo, Allyson Koyen, Arnulfo Mendoza, James J. Morrow
Summary of BONCAT proteomic analysis of mRNA translation during metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5641c783a1f4cb045291261a2bfe4c
https://doi.org/10.1158/1078-0432.22468893
https://doi.org/10.1158/1078-0432.22468893
Autor:
S. Gail Eckhardt, Robert A. Winn, Wells A. Messersmith, James V. DeGregori, Daniel L. Gustafson, Kelly L. McPhillips, Timothy P. Newton, Heather M. Selby, Lindsey N. Micel, Jihye Kim, Ryan J. Hansen, Martine C. McManus, Peter J. Klauck, John J. Arcaroli, Mark A. Gregory, Aik Choon Tan, Todd M. Pitts, John J. Tentler, Anna Spreafico
Supplementary Figure Legends - PDF file 100K, Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b0d8fb2125fd7a4c5ea3387e488e6c
https://doi.org/10.1158/1078-0432.22446345.v1
https://doi.org/10.1158/1078-0432.22446345.v1
Autor:
Chand Khanna, Peter C. Scacheri, Timothy M. Fan, Ming Zhou, Daniel L. Gustafson, Ryan J. Hansen, Timothy J. Waybright, Ling Ren, Michael M. Lizardo, Allyson Koyen, Arnulfo Mendoza, James J. Morrow
Highly metastatic osteosarcoma cells activate the mTOR pathway during metastatic progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9dfd5d9a8e75dd89d47a80b6f9924e
https://doi.org/10.1158/1078-0432.22468896
https://doi.org/10.1158/1078-0432.22468896