Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ryan J Guasp"'
Autor:
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll
Publikováno v:
eLife, Vol 13 (2024)
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as e
Externí odkaz:
https://doaj.org/article/c7cece9d67354cd59c1a7a7f1b5a4181
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C.Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Under conditions of proteostasis disequilibrium, neurons can enhance intracellular and extracellular protective mechanisms to guard against neurotoxicity. In mammals, an intracellular response to severe proteostasis imbalance that results from proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd67597b046726c06f36991d5d63358
https://doi.org/10.1101/2022.08.03.501714
https://doi.org/10.1101/2022.08.03.501714
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249fd4c969248c1b2ec77969cc9aa39
http://europepmc.org/articles/PMC8433523
http://europepmc.org/articles/PMC8433523
Autor:
Christian Neri, KC Q Nguyen, Christopher V. Gabel, Marton L. Toth, J. Alex Parker, Ryan J. Guasp, Girish Harinath, Meghan Lee Arnold, Monica Driscoll, Ilija Melentijevic, David H. Hall, Daniel G. Taub
Publikováno v:
Nature
Nature, Nature Publishing Group, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Nature, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Nature, Nature Publishing Group, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Nature, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis. Monica Driscoll and colleagues show that in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423cadf2d54348eaea6d880aeec65179
https://hal.archives-ouvertes.fr/hal-01545495
https://hal.archives-ouvertes.fr/hal-01545495
Autor:
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J. Guasp, Ken C. Q. Nguyen, Ge Bai, David H. Hall, Barth D. Grant, Monica Driscoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology. We found that in C. elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are
Externí odkaz:
https://doaj.org/article/7789921720d54283b486c645e8eba774