Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ryan J, Donahue"'
Autor:
Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then pe
Externí odkaz:
https://doaj.org/article/7657e4fe09f54146a892dfbcaf469f51
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Abstract Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step
Externí odkaz:
https://doaj.org/article/680aac1197894499b42cbfae53274c72
Autor:
Nicole A. Muench, Sonia Patel, Margaret E. Maes, Ryan J. Donahue, Akihiro Ikeda, Robert W. Nickells
Publikováno v:
Cells, Vol 10, Iss 7, p 1593 (2021)
The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in the central nervous system with respect to
Externí odkaz:
https://doaj.org/article/881a629da11c4c40a617383655be56e0
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-11 (2021)
Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step in the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0563af65a86fea3ef865813a52b8e7
https://doaj.org/article/680aac1197894499b42cbfae53274c72
https://doaj.org/article/680aac1197894499b42cbfae53274c72
Publikováno v:
Mol Neurobiol
BACKGROUND: Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax(+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d133e8ba52c26921ab81f12b7b3e4d5
https://doi.org/10.1007/s12035-019-01783-7
https://doi.org/10.1007/s12035-019-01783-7
Publikováno v:
Cell Death & Disease
Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has been shown to be the determining step in the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16486af379655b0bde86ad8fc9aae3e4
https://pubmed.ncbi.nlm.nih.gov/34376637
https://pubmed.ncbi.nlm.nih.gov/34376637
Autor:
Cherie Holcomb, Haydeh Payami, Erin M. Hill-Burns, William T. Wissemann, Bryan Hoglund, Ryan J. Donahue, Nikolaos A. Patsopoulos, Glenys Thomson, Cyrus P. Zabetian, Henry A. Erlich, Stewart A. Factor
Publikováno v:
The American Journal of Human Genetics. 93:984-993
Historically, association of disease with the major histocompatibility complex (HLA) genes has been tested with HLA alleles that encode antigen-binding affinity. The association with Parkinson disease (PD), however, was discovered with noncoding SNPs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc12bb1b6cf5da336ce8c2627197f69
https://doi.org/10.1016/j.ajhg.2013.10.009
https://doi.org/10.1016/j.ajhg.2013.10.009