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Akademický článek

Hadronic mono-W′ probes of dark matter at colliders

Autor: Ryan Holder, John Reddick, Matteo Cremonesi, Doug Berry, Kun Cheng, Matthew Low, Tim M. P. Tait, Daniel Whiteson

Publikováno v: Journal of High Energy Physics, Vol 2024, Iss 6, Pp 1-14 (2024)

Abstract Particle collisions at the energy frontier can probe the nature of invisible dark matter via production in association with recoiling visible objects. We propose a new potential production mode, in which dark matter is produced by the decay

Externí odkaz: https://doaj.org/article/c5d1bd7a32724d139c433f873e041885

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Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease

Autor: Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov

Publikováno v: Nucleic Acid Therapeutics. 31:324-340

Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2000bde8307608b78ff279a1e4c61b
https://doi.org/10.1089/nat.2021.0026

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Discovery of Melanocortin Ligands via a Double Simultaneous Substitution Strategy Based on the Ac-His-dPhe-Arg-Trp-NH2 Template

Autor: Aleksandar Todorovic, Carrie Haskell-Luevano, Cody J. Lensing, Joseph W. Scott, Jerry Ryan Holder, Nicholas B. Sorensen

Publikováno v: ACS Chemical Neuroscience. 9:2753-2766

The melanocortin system regulates an array of diverse physiological functions including pigmentation, feeding behavior, energy homeostasis, cardiovascular regulation, sexual function, and steroidogenesis. Endogenous melanocortin agonist ligands all p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2b65d765430c9bfed8c7b0134c6f934
https://doi.org/10.1021/acschemneuro.8b00181

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Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Autor: John G. Allen, Brian A. Lanman, Jerry Ryan Holder, Bryant Yang, Anthony B. Reed, Les P. Miranda, Sara C. Humphreys, Joyce Chi Yee Chan, Ji Ma, Zhican Wang, Gayathri Swaminath

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:127499

Agonism of the endothelial receptor APJ (putative receptor protein related to AT1; AT1: angiotensin II receptor type 1) has the potential to ameliorate congestive heart failure by increasing cardiac output without inducing hypertrophy. Although the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6348329f5a66f364c1e9afc3ee5606
https://doi.org/10.1016/j.bmcl.2020.127499

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Discovery of Melanocortin Ligands via a Double Simultaneous Substitution Strategy Based on the Ac-His-dPhe-Arg-Trp-NH

Autor: Aleksandar, Todorovic, Cody J, Lensing, Jerry Ryan, Holder, Joseph W, Scott, Nicholas B, Sorensen, Carrie, Haskell-Luevano

Publikováno v: ACS chemical neuroscience. 9(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad13b17a4f82d79158bd8808e0d1a7d5
https://pubmed.ncbi.nlm.nih.gov/29783840

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Sustained inhibition of the Na V 1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Autor: Joseph Ligutti, Les P. Miranda, Fen-Fen Lin, Shi-Yuan Meng, Anruo Zou, Stefan I. McDonough, Kaustav Biswas, Dong Liu, Kristin L. Andrews, Bryan D. Moyer, J. Ryan Holder, Justin K. Murray, Leszek Poppe

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 25:4866-4871

Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel Na V 1.7 as new analgesics. Thus far, however, in vitro selectivity has proved difficult for small molecules, and peptides generally lack appropriate pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8eefd5b7362c35832a0347862bf39f
https://doi.org/10.1016/j.bmcl.2015.06.033

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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Autor: Eileen Johnson, Jerry Ryan Holder, Barton H. Manning, Licheng Shi, Kevin Salyers, Michael Stenkilsson, Colin V. Gegg, Marie E. Wright, George Doellgast, Kenneth D. Wild, Les P. Miranda

Publikováno v: Biopolymers. 100:422-430

Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ea37007135bf79af7cc0c5558bc94bf
https://doi.org/10.1002/bip.22270

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Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS

Autor: Mark J. Rose, Jerry Ryan Holder, Christopher A. James, Hongyan Li, Marie E. Wright, Les P. Miranda

Publikováno v: Journal of the American Society for Mass Spectrometry. 22:1660-1667

PEGylation is a successful strategy to improve the pharmacokinetic and pharmaceutical properties of therapeutic peptides. However, quantitative analysis of PEGylated peptides in biomatrix by LC-MS/MS poses significant analytical challenge due to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db315adb8797a3563302defca091f233
https://doi.org/10.1007/s13361-011-0180-2

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