Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ryan Hausler"'
Autor:
Jacquelyn Powers, Daniel J. Lee, Kara N. Maxwell, Casey Morrison, Rachel L. Kember, Vivek Narayan, Abigail Doucette, Scott M. Damrauer, James Ding, Gregory Kelly, Heena Desai, Ryan Hausler, Renae Judy, Susan M. Domchek, Emily Feld, Lauren E. Schwartz, Peter Gabriel, Anh N Le, Daniel J. Rader, JoEllen Weaver
Publikováno v:
European Urology. 81:559-567
Background Identification of germline mutations in DNA repair genes has significant implications for the personalized treatment of individuals with prostate cancer (PrCa). Objective To determine DNA repair genes associated with localized PrCa in a di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a97b296938ff846ba700a2ebe13aeb
https://doi.org/10.1016/j.eururo.2021.09.029
https://doi.org/10.1016/j.eururo.2021.09.029
Autor:
Luca F Valle, Nicholas G Nickols, Ryan Hausler, Patrick R Alba, Tori Anglin-Foote, Cristina Perez, Kosj Yamoah, Brent S Rose, Michael J Kelley, Scott L DuVall, Isla P Garraway, Kara N Maxwell, Julie A Lynch
Publikováno v:
The oncologist, vol 28, iss 6
Oncologist
Oncologist
Black Veterans have higher a incidence of localized and metastatic prostate cancer compared to White Veterans yet are underrepresented in reports of frequencies of somatic and germline alterations. This retrospective analysis of somatic and putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79601709d427ae0587dbcac398b538
https://doi.org/10.1093/oncolo/oyad042
https://doi.org/10.1093/oncolo/oyad042
Autor:
Kara N. Maxwell, Maureen E. Murphy, Raul C. Ribeiro, Gerard P. Zambetti, Richard W. Kriwacki, Sheri L. Spunt, Carolyn Fein Levy, Morris C. Edelman, Brooke Levin, Fergus J. Couch, Kelly McGoldrick, Stephanie Gutierrez, Jill S. Dolinsky, Kenneth Offit, Vijai Joseph, Judy E. Garber, Jill E. Stopfer, Jeffrey N. Weitzel, Thomas P. Slavin, Susan M. Domchek, Katherine L. Nathanson, Kristin Zelley, Louise C. Pyle, Suzanne P. MacFarland, Marilyn M. Li, Anh N. Le, Gregory Kelly, Ryan Hausler, Heena Desai, Aaron H. Philips, Andrew V. Kossenkov, Tetyana Martynyuk, Jessica C. Leung, Thibaut Barnoud, Emilia M. Pinto, Jacquelyn Powers
Supplementary Figures 1-4. Supplementary Figure S1: Full Pedigrees from TP53 c.1000G>C;p.G334R clinically ascertained families. Fam ID allows reference to Table 1; Supplementary Figure S2: Constructs encoding p53 wild-type (TP53-WT), p53-R175H (TP53-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c00e89c5b7cf956aea60439d2d5560
https://doi.org/10.1158/0008-5472.22425756
https://doi.org/10.1158/0008-5472.22425756
Autor:
Kara N. Maxwell, Maureen E. Murphy, Raul C. Ribeiro, Gerard P. Zambetti, Richard W. Kriwacki, Sheri L. Spunt, Carolyn Fein Levy, Morris C. Edelman, Brooke Levin, Fergus J. Couch, Kelly McGoldrick, Stephanie Gutierrez, Jill S. Dolinsky, Kenneth Offit, Vijai Joseph, Judy E. Garber, Jill E. Stopfer, Jeffrey N. Weitzel, Thomas P. Slavin, Susan M. Domchek, Katherine L. Nathanson, Kristin Zelley, Louise C. Pyle, Suzanne P. MacFarland, Marilyn M. Li, Anh N. Le, Gregory Kelly, Ryan Hausler, Heena Desai, Aaron H. Philips, Andrew V. Kossenkov, Tetyana Martynyuk, Jessica C. Leung, Thibaut Barnoud, Emilia M. Pinto, Jacquelyn Powers
Germline mutations in TP53 cause a rare high penetrance cancer syndrome, Li–Fraumeni syndrome (LFS). Here, we identified a rare TP53 tetramerization domain missense mutation, c.1000G>C;p.G334R, in a family with multiple late-onset LFS-spectrum canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b22083b0736e430d002f93b84e42e5
https://doi.org/10.1158/0008-5472.c.6512130
https://doi.org/10.1158/0008-5472.c.6512130
Autor:
John Pluta, Ryan Hausler, Brad Wubbenhorst, Heena Desai, Susan M. Domchek, Katherine L. Nathanson, Kara N. Maxwell
BackgroundBreast and ovarian tumors in patients with biallelic BRCA1 and BRCA2 mutations either by germline mutations accompanied by allele-specific loss of heterozygosity (LOH) or truncal somatic mutations respond to PARP inhibition. The repair of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2bded2300e5878452f7ec21ae45ffe4
https://doi.org/10.1101/2022.09.08.506670
https://doi.org/10.1101/2022.09.08.506670
Publikováno v:
European Urology. 82:e170-e171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eaa7f2808696ab4e5d16870566f9a9b
https://doi.org/10.1016/j.eururo.2022.08.025
https://doi.org/10.1016/j.eururo.2022.08.025
Autor:
Nicholas S. Wilcox, Kara Maxwell, Heena Desai, Ryan Hausler, Gregory Kelly, Wumesh KC, Martin Carroll, Angela DeMichele, Bonnie Ky
Publikováno v:
Journal of the American College of Cardiology. 81:2399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd4283db5c8df08ff5f9f8777aacf74
https://doi.org/10.1016/s0735-1097(23)02843-7
https://doi.org/10.1016/s0735-1097(23)02843-7
Autor:
Fergus J. Couch, Marilyn M. Li, Tetyana Martynyuk, Kelly McGoldrick, Suzanne P. MacFarland, Judy Garber, Heena Desai, Raul C. Ribeiro, Jessica C. Leung, Katherine L. Nathanson, Stephanie Gutierrez, Kara N. Maxwell, Jeffrey N. Weitzel, Emilia M. Pinto, Richard W. Kriwacki, B. Levin, Louise C. Pyle, Anh N Le, Ryan Hausler, Gerard P. Zambetti, Andrew V. Kossenkov, Maureen E. Murphy, Sheri L. Spunt, Kenneth Offit, Thibaut Barnoud, Aaron H. Philips, Vijai Joseph, Morris Edelman, Jacquelyn Powers, Gregory Kelly, Kristin Zelley, Thomas P. Slavin, Jill S. Dolinsky, Jill E. Stopfer, Susan M. Domchek, Carolyn Fein Levy
Publikováno v:
Cancer Research. 80:3732-3744
Germline mutations in TP53 cause a rare high penetrance cancer syndrome, Li–Fraumeni syndrome (LFS). Here, we identified a rare TP53 tetramerization domain missense mutation, c.1000G>C;p.G334R, in a family with multiple late-onset LFS-spectrum canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e54724e4dbe56432827206d783db53eb
https://doi.org/10.1158/0008-5472.can-20-1390
https://doi.org/10.1158/0008-5472.can-20-1390
Publikováno v:
Bioinformatics
Motivation RNA-seq technology provides unprecedented power in the assessment of the transcription abundance and can be used to perform a variety of downstream tasks such as inference of gene-correlation network and eQTL discovery. However, raw gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09339b05716c8ffd1ea75ce67287843b
https://doi.org/10.1093/bioinformatics/btaa745
https://doi.org/10.1093/bioinformatics/btaa745
Autor:
Joseph Vijai, Ryan Hausler, Kenneth Offit, Wendy Kohlmann, Wassim Abida, Sophie Hyman, Piper Nicolosi, Heather H. Cheng, Jennie Vagher, Eliezer M. Van Allen, Brian H. Shirts, Maria I. Carlo, Daniel J. Lee, Marianne E Dubard-Gault, Mercy Y. Laurino, Anh D. Le, Eric Q. Konnick, Jacquelyn Powers, Luke Maese, Lauren E. Schwartz, Anne Naumer, Kara N. Maxwell, Lorraine V. Naylor, Bruce Montgomery, Colin C. Pritchard, Joshua D. Schiffman, Casey Morrison, Roman Gulati, Bastien Nguyen, Jill E. Stopfer, Oliver Sartor, Zsofia K. Stadler, Peter S. Nelson, Samantha Greenberg, Judy Garber, Saud H. AlDubayan, Robert L. Nussbaum, Michael Walsh, Diana Mandelker, Michael J. Morris, Elisa Ledet
Publikováno v:
Eur Urol
BACKGROUND: Inherited germline TP53 pathogenic and likely pathogenic mutations (gTP53) cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome (LFS). However, there is no known association of prostate cancer with gTP53. OBJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25f5caee2992fd009f0ea66e51f00cd
https://europepmc.org/articles/PMC8891030/
https://europepmc.org/articles/PMC8891030/