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pro vyhledávání: '"Ryan Hastie"'
Autor:
Anand Balasubramani, Xing Chang, Susan Togher, Harri Lähdesmäki, Jed A. Bassein, Ryan Hastie, Antti Larjo, Anjana Rao
Publikováno v:
Nature Communications
ASXL1 is the obligate regulatory subunit of a deubiquitinase complex whose catalytic subunit is BAP1. Heterozygous mutations of ASXL1 that result in premature truncations are frequent in myeloid leukemias and Bohring–Opitz syndrome. Here we demonst
Autor:
Thierry Oddos, Anjana Rao, Matthieu Vandenberghe, Roman Skryma, Natalia Prevarskaya, Ryan Hastie, Maylis Raphaël, V’yacheslav Lehen’kyi, Patrick G. Hogan, Dmitri V. Gordienko
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (50), ⟨10.1073/pnas.1310394110⟩
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (50), ⟨10.1073/pnas.1310394110⟩
International audience; To achieve and maintain skin architecture and homeostasis, keratinocytes must intricately balance growth, differentiation, and polarized motility known to be governed by calcium. Orai1 is a pore subunit of a store-operated Ca(
Autor:
Ryan Hastie, Anjana Rao, Klaus Rajewsky, Elizabeth C. Thompson, Edward D. Lamperti, Sergei B. Koralov, Hozefa S. Bandukwala, Jungeun An, Myunggon Ko, Angeliki Tsangaratou
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(35)
The Ten-Eleven-Translocation 2 ( TET2 ) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently ob
Autor:
Myunggon Ko, Jungeun An, Anjana Rao, Angeliki Tsangaratou, Hozefa S. Bandukwala, Sergei B. Koralov, Ryan Hastie, Elizabeth C. Thompson, Edward D. Lamperti, Klaus Rajewsky
Publikováno v:
Blood. 118:2354-2354
Abstract 2354 Epigenetic alterations in cancer cells include aberrant DNA methylation and histone modifications. Specifically, cancer cells display global hypomethylation associated with genomic instability as well as promoter hypermethylation associ