Výsledky vyhledávání - "Ryan H. Zhang"

Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase

Autor: Jenny Beebe, Sophia Josephraj, Chao J. Wang, Jacob Danielson, Qingbin Cui, Caoqinglong Huang, Lincoln Barlow, Ryan H. Zhang, Taolan Zhang, Harikrishna Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang

Publikováno v: Journal of Medicinal Chemistry. 65:13681-13691

Fatty acid synthase (FASN), a sole cytosolic enzyme responsible for de-novo lipid synthesis, is overexpressed in cancer but not in normal non-lipogenic tissues. FASN has been targeted, albeit no such inhibitor has been approved. Proton pump inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f985ce71de4643d861f34689f9c7d789
https://doi.org/10.1021/acs.jmedchem.2c00642

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