Výsledky vyhledávání - "Ryan H, Cunnington"

Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results

Autor: Henry J. Duff, Jameson A. Dundas, Daniyil A. Svystonyuk, D. Park, Guoqi Teng, Simranjit S. Pattar, Subodh Verma, Darrell D. Belke, Jason R.B. Dyck, Paul W.M. Fedak, Ryan H. Cunnington, Sean Kang, David G. Guzzardi, Jeannine D. Turnbull, Ali Fatehi Hassanabad, Lee Anne Tibbles

Publikováno v: Canadian Journal of Cardiology. 36:543-553

Background Empagliflozin, an SGLT2 inhibitor, has shown remarkable reductions in cardiovascular mortality and heart failure admissions (EMPA-REG OUTCOME). However, the mechanism underlying the heart failure protective effects of empagliflozin remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5459201faee52fe54961c8a92e16afc4
https://doi.org/10.1016/j.cjca.2019.08.033

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c-Ski, Smurf2, and Arkadia as regulators of TGF-β signaling: new targets for managing myofibroblast function and cardiac fibrosisThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba

Autor: Ryan H. Cunnington, Ian M.C. Dixon, Mansoreh NazariM. Nazari

Publikováno v: Canadian Journal of Physiology and Pharmacology. 87:764-772

Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transformin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d311d50d61487a001ed634831e102ff
https://doi.org/10.1139/y09-076

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The participation of the Na+–Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation

Autor: Kristen M. Bedosky, Ryan H. Cunnington, Ian M.C. Dixon, Jelena Komljenovic, Sunil G. Rattan, Cicie Deng, Joshua E. Raizman, Darren H. Freed, Rose Chang

Publikováno v: Journal of Cellular Physiology. 213:540-551

Cardiac ventricular myofibroblast motility, proliferation, and contraction contribute to post-myocardial infarct wound healing, infarct scar formation, and remodeling of the ventricle remote to the site of infarction. The Na+-Ca2+ exchanger (NCX1) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66c3907c7d121544224c33af4b3090
https://doi.org/10.1002/jcp.21134

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Cardiac Fibrosis and Heart Failure—Cause or Effect?

Autor: Sunil G. Rattan, Jeffrey T. Wigle, Ryan H. Cunnington, Ian M.C. Dixon

Publikováno v: Cardiac Fibrosis and Heart Failure: Cause or Effect? ISBN: 9783319174365
Cardiac Fibrosis and Heart Failure: Cause or Effect?

Cardiac fibrosis is the pathological accumulation of cardiac extracellular matrix (ECM or matrix), which occurs in most types of heart disease. Major recent advances in our understanding have allowed us to identify cardiac fibrosis as a primary disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a431e69566ed353448166a275e861f11
https://doi.org/10.1007/978-3-319-17437-2_1

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Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart

Autor: Ryan H. Cunnington, Ian M.C. Dixon, Jayda S Sutton, Darren H. Freed, Aran L. Dangerfield

Publikováno v: Cardiovascular Research. 65:782-792

Ischemic heart disease is the most common cause of mortality worldwide. Cardiac fibroblasts and myofibroblasts, i.e., the hypersecretory, muscular, and contractile fibroblastic phenotype variant, play an important role in myocardial healing and are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d6bd1dd1d5e2e720d3cd056abbe084
https://doi.org/10.1016/j.cardiores.2004.11.026

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Mast Cells and Cardiac Fibroblasts

Autor: Ryan H. Cunnington, Ian M.C. Dixon

Publikováno v: Hypertension. 58:142-144

See related article, pp 264–270 The term “fibroblast” designates a highly heterogenous group of cells that exhibit distinct differentiated phenotypes in different organs.1 The study of fibroblast and myofibroblast biology in specific organs is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e88a74eb5d2b01b6c1c9840b26db37be
https://doi.org/10.1161/hypertensionaha.111.174748

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Control of Cardiac Fibroblast Phenotype by the Meox2/Zeb2 Signalling Switch (LB47)

Autor: Sunil G. Rattan, Fahmida Jahan, David Cheung, Ryan H. Cunnington, Jeffrey T. Wigle, Ian M.C. Dixon, Krista L. Filomeno, Josette M. Northcott

Publikováno v: The FASEB Journal. 28

The fibroblast to myofibroblast phenoconversion, which is induced by TGF-β, is a crucial step during cardiac fibrosis. Activated myofibroblasts increase extracellular matrix (ECM) synthesis, which ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aff89d34e462c99d706650ade099fd1
https://doi.org/10.1096/fasebj.28.1_supplement.lb47

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The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype

Autor: Saeid Ghavami, Jared J.L. Davies, Krista L. Filomeno, Jeffrey T. Wigle, Ryan H. Cunnington, Ian M.C. Dixon, Josette M. Northcott, Fahmida Jahan, Morvarid S. Kavosh

Publikováno v: Journal of cell science. 127(Pt 1)

Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect the myofi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07771b41e993cbcbcafca7237720ab9
https://pubmed.ncbi.nlm.nih.gov/24155330

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