Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ryan G. Gaudet"'
Autor:
Ryan G. Gaudet, Cynthia X. Guo, Raphael Molinaro, Haila Kottwitz, John R. Rohde, Anne-Sophie Dangeard, Cécile Arrieumerlou, Stephen E. Girardin, Scott D. Gray-Owen
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1418-1430 (2017)
Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on
Externí odkaz:
https://doaj.org/article/87f0ff614cc546fd974eada382523798
Autor:
Teresa R. O’Meara, Kwamaa Duah, Cynthia X. Guo, Michelle E. Maxson, Ryan G. Gaudet, Kristy Koselny, Melanie Wellington, Michael E. Powers, Jessie MacAlpine, Matthew J. O’Meara, Amanda O. Veri, Sergio Grinstein, Suzanne M. Noble, Damian Krysan, Scott D. Gray-Owen, Leah E. Cowen
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans un
Externí odkaz:
https://doaj.org/article/37c1c8c11e4b4ed3843ff6f59b92ef9d
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of bacterial, host
Externí odkaz:
https://doaj.org/article/f33afe0fb3034b60aed4967ef1b0445e
Autor:
Rodolfo Urbano, Eui-Soon Park, Kyle Tretina, Alexandru Tunaru, Ryan G. Gaudet, Xiaoyun Hu, Da-Zhi Wang, John D. MacMicking
Actin is integral to eukaryotic physiology as a biomechanical polymer and as a structural barrier for cell-autonomous defense against infection. Some microbial pathogens exploit the actin cytoskeleton, however, to evade cell-autonomous immunity. Subv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d75f680f811b5a1257fb9e7454c8ac
https://doi.org/10.1101/2022.08.28.505595
https://doi.org/10.1101/2022.08.28.505595
Autor:
Erdem Karatekin, Shiwei Zhu, Thanh Ngoc Nguyen, Michael Lazarou, Clinton J. Bradfield, John D. MacMicking, Kallol Gupta, Anushka Halder, Ryan G. Gaudet, Shuai Huang, Bae Hoon Kim, Agnieszka Maminska, Dijin Xu
Publikováno v:
Science. 373
Cleansing the cytosol Most human cells, not just those belonging to the immune system, mount protective responses to infection when activated by the immune cytokine interferon-gamma (IFN-γ). How IFN-γ confers this function in nonimmune cells and ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1047e76729236dd938fa05d16ba46cf4
https://doi.org/10.1126/science.abf8113
https://doi.org/10.1126/science.abf8113
Autor:
Jeffrey Downey, Leandro Silva da Costa, Armin Farahvash, Stephen E. Girardin, Aaron Trotman-Grant, Ryan G. Gaudet, Maziar Divangahi, Leticia A.M. Carneiro, Damien Arnoult, Farshad C. Azimi, Jeffrey E. Lee, Charles C. Y. Lau, Raphael Molinaro, Nichole K. Escalante, Dave Prescott, Scott D. Gray-Owen, Elise Sofie Hovingh, J J Chen, Ahmed Outlioua, Dana J. Philpott, Jessica Tsalikis, Rob van Dalen, Mena Abdel-Nour
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩
Science, American Association for the Advancement of Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩
Linking protein misfolding and innate immunity Multiple innate immune sensors undergo rapid assembly into large complexes known as signalosomes. This is an essential step during cellular responses to microbes and danger signals. How this process is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3b5e2219bef4b686ba89411fd9f65b
https://doi.org/10.1126/science.aaw4144
https://doi.org/10.1126/science.aaw4144
Autor:
Leah E. Cowen, Amanda O. Veri, Michelle E. Maxson, Scott D. Gray-Owen, Michael E. Powers, Melanie Wellington, Kwamaa Duah, Kristy Koselny, Suzanne M. Noble, Sergio Grinstein, Cynthia X. Guo, Damian J. Krysan, Ryan G. Gaudet, Matthew J. O’Meara, Teresa R. O’Meara, Jessie MacAlpine
Publikováno v:
Microbial Cell
mBio, vol 9, iss 4
mBio
mBio, Vol 9, Iss 4, p e01581-18 (2018)
mBio, Vol 9, Iss 4 (2018)
mBio, vol 9, iss 4
mBio
mBio, Vol 9, Iss 4, p e01581-18 (2018)
mBio, Vol 9, Iss 4 (2018)
The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans undergoes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be55fe2faa77183175ac93343ff51d9
https://pubmed.ncbi.nlm.nih.gov/30533421
https://pubmed.ncbi.nlm.nih.gov/30533421
Autor:
Jianjun Li, Carolyn M. Buckwalter, Anna Sintsova, Jason Moffat, Nelly Leung, Alan Cochrane, Ryan G. Gaudet, Scott D. Gray-Owen, Andrew D. Cox
Publikováno v:
Science. 348:1251-1255
Detecting Gramnegative bacteria Invariant molecules specific to different classes of microbes, but not expressed by eukaryotic cells, alert the immune system to a potential invader. Gaudet et al. identified one such molecule expressed by a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab7f9b2e9f0ee2cffa43ac09d6d8469
https://doi.org/10.1126/science.aaa4921
https://doi.org/10.1126/science.aaa4921
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
mBio
mBio, Vol 8, Iss 4, p e01168-17 (2017)
mBio
mBio, Vol 8, Iss 4, p e01168-17 (2017)
Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of bacterial, host genetic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fcc18336e6efe8f1722f28df5d06ca
https://journals.asm.org/doi/10.1128/mBio.01168-17
https://journals.asm.org/doi/10.1128/mBio.01168-17