Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii

Autor: Luke L. McGoldrick, Appu K. Singh, Lusine Demirkhanyan, Ting-Yu Lin, Ryan G. Casner, Eleonora Zakharian, Alexander I. Sobolevsky

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Transient receptor potential (TRP) channels are ubiquitous occurring cation-selective sensory ion channels that respond to various stimuli. Here the authors characterize crTRP1 from the alga Chlamydomonas reinhardtii, present its 3.5 Å cryo-EM struc

Externí odkaz: https://doaj.org/article/63a0a3a8fc3a440ba91ed9cb0c51a78f

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

Autor: Lihong Liu, Ryan G. Casner, Yicheng Guo, Qian Wang, Sho Iketani, Jasper Fuk-Woo Chan, Jian Yu, Bernadeta Dadonaite, Manoj S. Nair, Hiroshi Mohri, Eswar R. Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D. Bloom, Lawrence Shapiro, David D. Ho

Publikováno v: bioRxiv

SUMMARYSARS-CoV-2 continues to evolve and evade most existing neutralizing antibodies, including all clinically authorized antibodies. We have isolated and characterized two human monoclonal antibodies, 12-16 and 12-19, which exhibited neutralizing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8dcb7a3556cd7c28fe78eb9ee02c16
https://europepmc.org/articles/PMC10120718/

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Autor: Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R. Reddem, Ryan G. Casner, Manoj S. Nair, Jian Yu, Jasper F.-W. Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C. Morano, Candace D. Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T. Yin, David S. Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D. Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D. Ho

Publikováno v: Science translational medicine. 14(646)

The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814f2a3609eb930beee05c6bd87c2bb3
https://pubmed.ncbi.nlm.nih.gov/35438546

Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS‐CoV ‐2

Autor: Bharat Madan, Eswar R. Reddem, Pengfei Wang, Ryan G. Casner, Manoj S. Nair, Yaoxing Huang, Ahmed S. Fahad, Matheus Oliveira Souza, Bailey B. Banach, Sheila N. López Acevedo, Xiaoli Pan, Rajani Nimrania, I‐Ting Teng, Fabiana Bahna, Tongqing Zhou, Baoshan Zhang, Michael T. Yin, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Brandon J. DeKosky

Publikováno v: Aiche Journal. American Institute of Chemical Engineers

Antiviral monoclonal antibody (mAb) discovery enables the development of antibody-based antiviral therapeutics. Traditional antiviral mAb discovery relies on affinity between antibody and a viral antigen to discover potent neutralizing antibodies, bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc97c3d62c9f788cd54c21da1d0500
https://doi.org/10.1002/aic.17440

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

Autor: Jasper Fuk-Woo Chan, Peter D. Kwong, Jian Yu, Lihong Liu, Kwok-Yung Yuen, Yicheng Guo, Ryan G. Casner, Manoj S. Nair, David D. Ho, Zizhang Sheng, Zhiwei Chen, Pengfei Wang, Sho Iketani, Gabriele Cerutti, Lawrence Shapiro, Yaoxing Huang, Maple Wang

Publikováno v: Emerging Microbes & Infections
article-version (VoR) Version of Record
bioRxiv
article-version (status) pre
article-version (number) 1
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 147-157 (2022)

The repeated emergence of highly pathogenic human coronaviruses as well as their evolving variants highlight the need to develop potent and broad-spectrum antiviral therapeutics and vaccines. By screening monoclonal antibodies (mAbs) isolated from CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bea924c28399ae3047b3471361a5009