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A Cerebroprotective Dose of Intravenous Citrate/Sorbitol-stabilized Dehydroascorbic Acid is Correlated with Increased Cerebral Ascorbic Acid and Inhibited Lipid Peroxidation after Murine Reperfused Stroke

Autor: Andrew F. Ducruet, Ryan G. King, William J. Mack, E. Sander Connolly, David J. Pinsky, Yuan Zhang, Weijia Guo, Ilya Laufer, J. Mocco

Publikováno v: Neurosurgery. 59:383-388

OBJECTIVE: Oxidative damage has been implicated in the pathogenesis of cerebral ischemia. We previously demonstrated that exogenously supplied dehydroascorbic acid (DHA), an oxidized, blood-brain barrier transportable form of the antioxidant ascorbic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625afabc0f10de8c4c5fea29096759c1
https://doi.org/10.1227/01.neu.0000223496.96945.a7

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Co-registration of radiographic and pathologic infarct territory in a non-human primate model of stroke

Autor: Brad E. Zacharia, Ryan G. King, Ricardo J. Komotar, Victoria Arango, J. Mocco, William J. Mack, E. Sander Connolly, Hilary G. Cohen, Andrew F. Ducruet, Evan R. Ransom

Publikováno v: Neurological Research. 27:634-637

Infarct volume correlation using magnetic resonance imaging (MRI) and pathology specimens enables exact tissue localization of cerebral injury following experimental stroke. We describe a protocol that enables co-registration of radiographic signal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed2784655bbcb3ed5070e8feb7c28a3
https://doi.org/10.1179/016164105x17305

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Laser Doppler Flowmetry in non-human primate stroke studies: model refinement for pre-clinical development of cerebroprotective strategies

Autor: Andrew F. Ducruet, Ryan G. King, James A. McKinnell, Anthony L. D'Ambrosio, Christopher J. Winfree, W. J. Mack, Daniel J. Hoh, Michael E. Sughrue, Edward Sander Connolly

Publikováno v: Acta Neurochirurgica. 145:1105-1110

¶Background. Safety, feasibility, and efficacy trials in non-human primate stroke models are essential to the evaluation of experimental therapies and their translation to humans. Although Laser Doppler Flowmetry has been successfully employed in ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d367a719b8975de5d9a6811bdcad955
https://doi.org/10.1007/s00701-003-0136-9

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An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia

Autor: Anthony L. D'Ambrosio, M. Nathan Nair, Ryan G. King, Andrew F. Ducruet, Robert R. Sciacca, Daniel J. Hoh, Judy Huang, Alexander L. Coon, William J. Mack, E. Sander Connolly, J D Mocco, Christopher J. Winfree

Publikováno v: Neurological Research. 25:280-284

There is renewed interest in primate models of acute stroke for the evaluation of potential therapeutic agents prior to clinical trials. The development of more precise functional outcome measures would improve the pre-clinical assessment of neuropro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930f77a64d8613ea2e9a35e48d5f556a
https://doi.org/10.1179/016164103101201346

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Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke

Autor: Robert R. Sciacca, Yuan Zhang, J. Mocco, Henry C. Marsh, William J. Mack, E. Sander Connolly, Alexander L. Coon, Michael E. Sughrue, David J. Pinsky, Sergei A. Sosunov, Andrew F. Ducruet, Ryan G. King

Publikováno v: Journal of neurosurgery. 105(4)

Object Postischemic cerebral inflammatory injury has been extensively investigated in an effort to develop effective neuroprotective agents. The complement cascade has emerged as an important contributor to postischemic neuronal injury. Soluble compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df86e3e0eda7442a4a9e764511ea89
https://pubmed.ncbi.nlm.nih.gov/17044564

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Intracranial pressure following aneurysmal subarachnoid hemorrhage: monitoring practices and outcome data

Autor: Ryan G. King, Kurt T. Kreiter, Ahmed Maghoub, William J. Mack, E. Sander Connolly, Stephan A. Mayer, J D Mocco, Andrew F. Ducruet

Publikováno v: Neurosurgical focus. 14(4)

Object Elevated intracranial pressure (ICP) is an important consequence of aneurysmal subarachnoid hemorrhage (SAH) that often results in decreased cerebral perfusion and secondary clinical decline. No definitive guidelines exist regarding methods an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9bf78add61a18b1aec8c63bdee052b
https://pubmed.ncbi.nlm.nih.gov/15679302

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