Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Ryan Fleming"'
Autor:
R. James Christie, Arnaud C. Tiberghien, Qun Du, Binyam Bezabeh, Ryan Fleming, Amanda Shannon, Shenlan Mao, Shannon Breen, Jing Zhang, Haihong Zhong, Jay Harper, Herren Wu, Philip W. Howard, Changshou Gao
Publikováno v:
Antibodies, Vol 6, Iss 4, p 20 (2017)
Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by selecting stable conjugation positions or hydrolysis of the thiosuccinimide. Here, we investigate
Externí odkaz:
https://doaj.org/article/d8a3eda79f854774ad8483d0cf099f77
Autor:
Adeela Kamal, Ronald Herbst, Robert E. Hollingsworth, David A. Tice, Philip W. Howard, Keven Huang, Mary Jane Hinrichs, Elaine M. Hurt, Haihong Zhong, Marlon Rebelatto, Sanjoo Jalla, Lilian van Vlerken-Ysla, Shannon Breen, Leslie Wetzel, Cui Chen, Linda Xu, Patrick Strout, Martin Korade, Allison M. Marrero, Shenlan Mao, Francois D'Hooge, Ryan Fleming, Jelena Jovanovic, David Bannister, Leeanne Lewis, Rose Marwood, Dorin Toader, Nazzareno Dimasi, Christopher Lloyd, Jay Harper
Supplementary Figure S1. Comparable internalization rates for 5T4_0108 and the 5T4-Tub ADC;Supplementary Figure S2. Affinity optimization improves in vitro cytotoxicity of a 5T4-ADC;Supplementary Figure S3. Induction of apoptosis by 5T4-PBD and 5T4-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de526dbdf0be492e85149344521acac5
https://doi.org/10.1158/1535-7163.22508511
https://doi.org/10.1158/1535-7163.22508511
Autor:
Jay Harper, Mark Cobbold, David A. Tice, Philip W. Howard, Ronald Herbst, Herren Wu, Changshou Gao, Luke A. Masterson, Kimberly Cook, Kathryn Pugh, Susan Wilson, Nazzareno Dimasi, Jens-Oliver Koopmann, Sonja Hess, Ryan Fleming, Sandrina Phipps, Allison M. Barrett, Hong Chen, Andrew Garcia, Gina D’Angelo, Wen Yu, Raghothama Chaerkady, Shenlan Mao
The addition of the ATR inhibitor, AZD6738, did not show synergistic cytotoxicity with SG3199 or ADCs in parental MDA-MB-361 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d95af0ffa8c167232f6d1a26846154
https://doi.org/10.1158/1535-7163.22521297.v1
https://doi.org/10.1158/1535-7163.22521297.v1
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Multiple myeloma is a hematologic cancer that disrupts normal bone marrow function and has multiple lines of therapeutic options, but is incurable as patients ultimately relapse. We developed a novel antibody–drug conjugate (ADC) targeting CS-1, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063a7b8839eda8429b31260763a0368a
https://doi.org/10.1158/1535-7163.c.6542664
https://doi.org/10.1158/1535-7163.c.6542664
Autor:
Jay Harper, Mark Cobbold, David A. Tice, Philip W. Howard, Ronald Herbst, Herren Wu, Changshou Gao, Luke A. Masterson, Kimberly Cook, Kathryn Pugh, Susan Wilson, Nazzareno Dimasi, Jens-Oliver Koopmann, Sonja Hess, Ryan Fleming, Sandrina Phipps, Allison M. Barrett, Hong Chen, Andrew Garcia, Gina D’Angelo, Wen Yu, Raghothama Chaerkady, Shenlan Mao
Differentially expressed proteins identified in the 361-PBDr cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c24ef074a6decab4f3756699682b81e
https://doi.org/10.1158/1535-7163.22521276.v1
https://doi.org/10.1158/1535-7163.22521276.v1
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Supplementary Materials and Methods, Supplementary Table S1. Sources of cell lines and cell growth media; Supplemental Table S2. Sources of antibodies for flow cytometry; Supplementary Table S3. CS-1 ADC Characteristics, Supplemental Table S4. Pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62318dd34971780d373a1e55ed154426
https://doi.org/10.1158/1535-7163.22520520.v1
https://doi.org/10.1158/1535-7163.22520520.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Supplementary Figure S1. Retention of MEDI3726 activity in human, cynomolgus monkey plasma or PBS for up to 7 days. Supplementary Figure S2. Kaplan-Meier analysis of the Time-to-Endpoint Survival in the (A) LNCaP, (B) CWR22Rv1, and (C) PC-3 Xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fba3333e7f01b57533060b9dc76a71f
https://doi.org/10.1158/1535-7163.22505436.v1
https://doi.org/10.1158/1535-7163.22505436.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Table S1. P values of comparing time to endpoint survival among all treatment groups in the LNCaP xenograft study Table S2. Summary of PSMA IHC in xenograft tumors Table S3. P values of comparing time to endpoint survival among all treatment groups i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231399c1a6b9388e7ff58e433d77c143
https://doi.org/10.1158/1535-7163.22505430
https://doi.org/10.1158/1535-7163.22505430
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4924695dc910a4941d12258d7652e0
https://doi.org/10.1158/1535-7163.22505433.v1
https://doi.org/10.1158/1535-7163.22505433.v1
Autor:
Patrick H. van Berkel, Ronald Herbst, David A. Tice, Steve Coats, John A. Hartley, Philip W. Howard, Neil H. Bander, Sae Kim, He Liu, Eva Corey, Simon Chivers, Mary Jane Masson Hinrichs, Martin Korade, Patrick Strout, Kevin Schifferli, Ravinder Tammali, Karma Dacosta, Wanda King, Charles E. Britten, Sandamali Dissanayake, Halla W. Reinert, Lauren Adams, Simon Corbett, Francois Bertelli, Nazzareno Dimasi, Kapil Vashisht, Ryan Fleming, Francois D'Hooge, Peter Tyrer, Noel R. Monks, Carin E.G. Havenith, David G. Williams, Francesca Zammarchi, Song Cho
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase that is highly expressed in nearly all prostate cancers with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The prevalence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::321b0f7676a6116fbc4184f047275750
https://doi.org/10.1158/1535-7163.c.6538059.v1
https://doi.org/10.1158/1535-7163.c.6538059.v1