Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ryan Ferrao"'
Publikováno v:
Nucleic Acids Research
Mycobacterial Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolysis to drive unidirectional 3′-to-5′ translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes en route. ATPase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef6a9612a952307e56fb665ccee06b3
https://doi.org/10.1093/nar/gkx1163
https://doi.org/10.1093/nar/gkx1163
Autor:
Qiubai Li, Hao Wu, Li Wang, Nathanael S. Gray, Hwan Geun Choi, Sara J. Buhrlage, Ryan Ferrao, John M. Hatcher
Publikováno v:
The Journal of biological chemistry. 294(12)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal transduction downstream of Toll-like receptors and interleukin-1 (IL-1) receptors. Upon ligand bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c24b55b295ac3e541d94414c2e2325
https://pubmed.ncbi.nlm.nih.gov/30679311
https://pubmed.ncbi.nlm.nih.gov/30679311
Autor:
Gladys de Leon Boenig, Alexis Rohou, Ryan Ferrao, Erin C. Dueber, Wayne J. Fairbrother, Elizabeth Helgason, Alberto Estevez, Michael J. Holliday
Publikováno v:
The Journal of biological chemistry. 293(43)
The caspase recruitment domain–containing protein 9 (CARD9)–B-cell lymphoma/leukemia 10 (Bcl10) signaling axis is activated in myeloid cells during the innate immune response to a variety of diverse pathogens. This signaling pathway requires a cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee2181f756d887f83e79be962ad65dd
https://pubmed.ncbi.nlm.nih.gov/30206119
https://pubmed.ncbi.nlm.nih.gov/30206119
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadce0d21c3316f5d789ce6f11fd0713
https://elifesciences.org/articles/38089
https://elifesciences.org/articles/38089
Autor:
Chen Shen, Sara J. Buhrlage, Ryan Ferrao, Hao Wu, Nathanael S. Gray, Li Wang, Qi Qiao, John M. Hatcher
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(51)
Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers through their role in Toll-like receptor (TLR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30962a1a2a20a3bce6c74ad6f72c6906
https://pubmed.ncbi.nlm.nih.gov/29208712
https://pubmed.ncbi.nlm.nih.gov/29208712
Autor:
Feizhen Wu, Shichong Liu, Kristina Hempel, Hao Wu, Jernej Murn, Yang Xiang, Lv Ruitu, Ryan Ferrao, Hanno Steen, Benoit Laurent, Yang Shi, Benjamin A. Garcia
Publikováno v:
Molecular cell, vol 57, iss 6
Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively. The molecular mechanism that underlies this dual substrate specificity has remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10484b666b6d18ee8205192cf2ab408
https://doi.org/10.1016/j.molcel.2015.01.010
https://doi.org/10.1016/j.molcel.2015.01.010
Autor:
Ryan Ferrao, Patrick J. Lupardus
Publikováno v:
Frontiers in Endocrinology
The Janus kinases (JAKs) are non-receptor tyrosine kinases essential for signaling in response to cytokines and interferons and thereby control many essential functions in growth, development, and immune regulation. JAKs are unique among tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d28f0eea576f7361f227f53351316bb
Publikováno v:
Molecular Cell. 55:891-903
Trans-autophosphorylation is among the most prevalent means of protein kinase activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 receptor signaling pathways, the kinase IRAK4 is recruited to the membrane-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfafb7ac728e7c2724593697af42d7c
https://doi.org/10.1016/j.molcel.2014.08.006
https://doi.org/10.1016/j.molcel.2014.08.006
Autor:
John G. Quinn, Yvonne Franke, Christine Tam, Heidi J.A. Wallweber, Hoangdung Ho, Ryan Ferrao, Patrick J. Lupardus
JAK1 is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases that are activated in response to cytokines and interferons. Here, we present two crystal structures of the human JAK1 FERM and SH2 domains bound to peptides derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05728ab7b86c289431ed75f3d1ad2dba
https://europepmc.org/articles/PMC4899269/
https://europepmc.org/articles/PMC4899269/
Autor:
Hao Wu, Ryan Ferrao
Publikováno v:
Current Opinion in Structural Biology. 22:241-247
Death domain (DD) superfamily members play a central role in apoptotic and inflammatory signaling through formation of oligomeric molecular scaffolds. These scaffolds promote the activation of proinflammatory and apoptotic initiator caspases, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ce7fb09fff06f9ddeb7ea34cc1ca03
https://doi.org/10.1016/j.sbi.2012.02.006
https://doi.org/10.1016/j.sbi.2012.02.006