Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ryan Faucette"'
Autor:
Dan Sexton, Ryan Faucette, Melody Rivera-Hernandez, Jon A. Kenniston, Nikolaos Papaioannou, Janja Cosic, Kris Kopacz, Gary Salmon, Chantal Beauchemin, Salomé Juethner, Dave Yeung
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
BackgroundCleaved high-molecular-weight kininogen (HKa) is a disease state biomarker of kallikrein-kinin system (KKS) activation in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH), the endogenous inhibitor of plasma kal
Externí odkaz:
https://doaj.org/article/0d761743922e42949564199f1786651f
Autor:
Samantha B. Nicholls, Ryan Faucette, David Chen, Sanela Bilic, Constance Martin, Ashish Kalra, Brian T. Welsh, Thomas Schurpf, Janice A. Lansita
Publikováno v:
International Journal of Toxicology
Checkpoint inhibitors offer a promising immunotherapy strategy for cancer treatment; however, due to primary or acquired resistance, many patients do not achieve lasting clinical responses. Recently, the transforming growth factor-β (TGFβ) signalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fc4be78ca0e0c6fa9df455a1a7bd00
https://doi.org/10.1177/1091581821998945
https://doi.org/10.1177/1091581821998945
Autor:
Frederick C. Streich, Susan C Lin, Samantha B. Nicholls, Ryan Faucette, Justin W. Jackson, Chris J Boston, Capili Allan, Anastasia Nikiforov, Kevin B. Dagbay, Erin Treece, Gregory J. Carven
Publikováno v:
The Journal of Biological Chemistry
Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6815c125823f4c0659cd139d3e3e71
http://europepmc.org/articles/PMC7170532
http://europepmc.org/articles/PMC7170532
Publikováno v:
Bioanalysis. 9:1477-1491
Aim: C1-INH-HAE is caused by activation of plasma kallikrein which subsequently cleaves high-molecular-weight kininogen (HMWK) to generate bradykinin and cHMWK. Materials & methods: A novel ion-pair 2D LC–MS/MS assay was developed to measure the 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81eeed9a72fa6dc704cf2245158d81a1
https://doi.org/10.4155/bio-2017-0105
https://doi.org/10.4155/bio-2017-0105
Autor:
Guochen Song, Justin F. Gainor, Colin D. Weekes, Yung Chyung, Lu Gan, Si Tuen Lee-Hoeflich, Yawen Ju, Timothy A. Yap, Minal A. Barve, Bruno Bockorny, Ryan Faucette, Johanna C. Bendell, Michelle Legler, Sanela Bilic
Publikováno v:
Journal of Clinical Oncology. 39:TPS3146-TPS3146
TPS3146 Background: Transforming growth factor-beta 1 (TGFβ1) is a key mediator of primary resistance to programmed cell death protein 1 (PD-1) pathway blockade. SRK-181 is a fully human, highly potent and selective monoclonal antibody that inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d7fdbc08feb1be7da0dbea2a3db47b
https://doi.org/10.1200/jco.2021.39.15_suppl.tps3146
https://doi.org/10.1200/jco.2021.39.15_suppl.tps3146
Autor:
Ryan Iarrobino, Joseph C. Biedenkapp, Burt Adelman, Chris Stevens, Jon A. Kenniston, Aleena Banerji, Marc A. Riedl, Christopher Tenhoor, H. Henry Li, Timothy J. Craig, James W. Baker, Carolyn Soo, Mark Davis-Lorton, Ryan Faucette, Richard F. Lockey, Henry J. Wedner, Marco Cicardi, Jonathan A. Bernstein, Mustafa Shennak, J. Gordon Still, Paula J. Busse, William R. Lumry, Joshua J. Jacobs, Harvey Kushner, Yung Chyung, Daniel J. Sexton, Ahmad Al-Ghazawi, Robert Mensah
Publikováno v:
The New England journal of medicine. 376(8)
Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-weight ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a724d42f89faa2f1a540689fc0c2a
https://pubmed.ncbi.nlm.nih.gov/28608074
https://pubmed.ncbi.nlm.nih.gov/28608074
Autor:
Allison P. Lindberg, Jie Chen, Jan Abendroth, Robert Charles Ladner, Thomas E. Edwards, Diana Martik, Mike DiLeo, Ryan Faucette, Andrew E. Nixon, Daniel J. Sexton, Shauna Mason, Jon A. Kenniston, Burt Adelman, Stephen R. Comeau, Janja Cosic, Niksa Kastrapeli, Christopher Tenhoor, Gregory P. Conley, Malini Viswanathan, Petr Kuzmic, Kris Kopacz
Publikováno v:
The Journal of Biological Chemistry
Background: Unregulated plasma kallikrein proteolytic activity can result from C1-inhibitor deficiency, causing excessive and potentially fatal edema. Results: The antibody DX-2930 potently and specifically inhibits plasma kallikrein and exhibits a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dfd0c35b9bdf7cd1872a9cb611d4d4
http://europepmc.org/articles/PMC4156074
http://europepmc.org/articles/PMC4156074
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
Autor:
Stephane Gesta, Thais Pentinat-Pelegrin, Jessica P. Otis, Josep C. Jimenez-Chillaron, Mary-Elizabeth Patti, Anne C. Ferguson-Smith, Ryan Faucette, Alice Chow, Rubén Díaz, Marika Charalambous, Elvira Isganaitis
Publikováno v:
Diabetes
OBJECTIVE—Low birth weight (LBW) is associated with increased risk of obesity, diabetes, and cardiovascular disease during adult life. Moreover, this programmed disease risk can progress to subsequent generations. We previously described a mouse mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37834040568e85520b349bc45229afa
https://doi.org/10.2337/db08-0490
https://doi.org/10.2337/db08-0490
Autor:
Sarah Crunkhorn, Wagner S. Da Silva, Ryan Faucette, Farrell Dearie, Antonio C. Bianco, Mary-Elizabeth Patti, Daniel Espinoza, Kristen Barry, Christos S. Mantzoros, Hiral Gami
Publikováno v:
Journal of Biological Chemistry. 282:15439-15450
Peroxisome proliferator activator receptor-γ coactivator 1 (PGC-1) is a major candidate gene for diabetes-related metabolic phenotypes, contributing to decreased expression of nuclear-encoded mitochondrial genes in muscle and adipose tissue. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99787861f42bc49a2e03d34e4293d82
https://doi.org/10.1074/jbc.m611214200
https://doi.org/10.1074/jbc.m611214200
Autor:
Mary-Elizabeth Patti, C. Reamer, K. Barry, Ryan Faucette, A. Oge, R. Przybyla, J. C. Jimenez-Chillaron, Elvira Isganaitis
Publikováno v:
Diabetologia. 50:1099-1108
Observational studies in humans suggest that low birthweight may decrease the risk of type 1 diabetes, but the mechanism is unknown. We hypothesised that antenatal undernutrition would decrease the incidence of type 1 diabetes in non-obese diabetic (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950d48fa1e1239ef2cb3fc5a5cab86ad
https://doi.org/10.1007/s00125-007-0617-0
https://doi.org/10.1007/s00125-007-0617-0