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pro vyhledávání: '"Ryan E. Pester"'
Autor:
Madhu S. Kumar, David G. Kirsch, Todd R. Golub, Tyler Jacks, Keara Michelle Lane, Cindy Y. Chen, Christine Chin, Jun Lu, Ryan E. Pester
Publikováno v:
Genes & Development. 23:2700-2704
MicroRNAs (miRNAs) are short, noncoding RNAs that function to suppress post-transcriptionally the expression of target mRNAs, predominately via inhibition of translation. Such translational inhibition relies on imperfect base-pairing between the miRN
Autor:
Phillip A. Sharp, Madhu S. Kumar, Ryan E. Pester, Margaret S. Ebert, Tyler Jacks, Stefan J. Erkeland, Cindy Y. Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 105:3903-3908
Many microRNAs (miRNAs) target mRNAs involved in processes aberrant in tumorigenesis, such as proliferation, survival, and differentiation. In particular, the let-7 miRNA family has been proposed to function in tumor suppression, because reduced expr