Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ryan E Bash"'
Autor:
Robert S McNeill, Emily E Stroobant, Erin Smithberger, Demitra A Canoutas, Madison K Butler, Abigail K Shelton, Shrey D Patel, Juanita C Limas, Kasey R Skinner, Ryan E Bash, Ralf S Schmid, C Ryan Miller
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200014 (2018)
BackgroundGlioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CAmut) in GBM are restricted to three functional domains: adaptor binding
Externí odkaz:
https://doaj.org/article/92b83fbb89a04d94995e568571c0a718
Autor:
Christian T. Stackhouse, Joshua C. Anderson, Zongliang Yue, Thanh Nguyen, Nicholas J. Eustace, Catherine P. Langford, Jelai Wang, James R. Rowland IV, Chuan Xing, Fady M. Mikhail, Xiangqin Cui, Hasan Alrefai, Ryan E. Bash, Kevin J. Lee, Eddy S. Yang, Anita B. Hjelmeland, C. Ryan Miller, Jake Y. Chen, G. Yancey Gillespie, Christopher D. Willey
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Key molecular regulators of acquired radiation resistance in recurrent glioblastoma (GBM) are largely unknown, with a dearth of accurate preclinical models. To address this, we generated 8 GBM patient-derived xenograft (PDX) models of acquired radiat
Externí odkaz:
https://doaj.org/article/f06e9a8597724e01bcfa17bb759ec86f
Autor:
Erin Smithberger, Abigail K. Shelton, Ryan E. Bash, Madison K. Butler, Alex R. Flores, Allie Stamper, Steven P. Angus, Michael P. East, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, Ryan Miller
Publikováno v:
Cancer Research. 82:1857-1857
Glioblastoma (GBM) is a malignant brain tumor that has proven difficult to treat, despite expressing promising targets such as EGFRvIII. EGFRvIII, a mutant version of the epidermal growth factor receptor (EGFR), is constitutively active and not prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf519dfd2f2bc2169f6ec44b6fd8956
https://doi.org/10.1158/1538-7445.am2022-1857
https://doi.org/10.1158/1538-7445.am2022-1857
Autor:
Abigail K. Shelton, Erin Smithberger, Madison Butler, Allie Stamper, Ryan E. Bash, Steve P. Angus, Michael P. East, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, Ryan Miller
Publikováno v:
Cancer Research. 82:3248-3248
Glioblastoma (GBM) is a devastating primary brain tumor with Citation Format: Abigail K. Shelton, Erin Smithberger, Madison Butler, Allie Stamper, Ryan E. Bash, Steve P. Angus, Michael P. East, Gary L. Johnson, Michael E. Berens, Frank B. Furnari, Ry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f78e02b527dfd59aa4fe0a1b4ee06175
https://doi.org/10.1158/1538-7445.am2022-3248
https://doi.org/10.1158/1538-7445.am2022-3248
Autor:
Stephen V. Frye, Lee Hwang, Christopher Ryan Miller, Henry Shelton Earp, Ryan E Bash, Masaki Terabe, Yu-Ting Su, Dragan Maric, Hua Song, Madison Butler, Wei Zhang, Mark R. Gilbert, Guangyang Yu, Allison N. Schorzman, Andy D Tran, Jing Wu, Ying Pang, William C. Zamboni, Xiaodong Wang, Meili Zhang
Publikováno v:
Neurooncol Adv
Background Glioblastoma-associated macrophages and microglia (GAMs) are the predominant immune cells in the tumor microenvironment. Activation of MerTK, a receptor tyrosine kinase, polarizes GAMs to an immunosuppressive phenotype, promoting tumor gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8b979cd7a219400547b87792c7d7f0
https://europepmc.org/articles/PMC7324055/
https://europepmc.org/articles/PMC7324055/
Autor:
Jing Wu, Matthew G. Ewend, Yu Ting Su, Erik P. Sulman, Ryan E. Bash, William C. Zamboni, David M. Irvin, H. Shelton Earp, Lauren N. Frady, Mark R. Gilbert, Allison N. Schorzman, C. Ryan Miller, Stephen V. Frye, Xiaodong Wang, Stephanie M. Cohen
Publikováno v:
Neuro-Oncology. 20:92-102
Background Glioma-associated macrophages and microglia (GAMs) are components of the glioblastoma (GBM) microenvironment that express MerTK, a receptor tyrosine kinase that triggers efferocytosis and can suppress innate immune responses. The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474f2ca66caaa8252696739f6bcaeafa
https://doi.org/10.1093/neuonc/nox111
https://doi.org/10.1093/neuonc/nox111
Autor:
Michael E. Berens, Seungchan Kim, Andrea M. Werneke, Marni B. Siegel, Jeremy M. Simon, Irvin Dm, Robert S. McNeill, Mark Vitucci, Miller Cr, Harshil Dhruv, Ralf S. Schmid, Ryan E. Bash
Publikováno v:
Neuro-Oncology. 19:1237-1247
Background Gliomas are diverse neoplasms with multiple molecular subtypes. How tumor-initiating mutations relate to molecular subtypes as these tumors evolve during malignant progression remains unclear. Methods We used genetically engineered mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d912d54ae4a172cee95678cbbb8f622
https://doi.org/10.1093/neuonc/nox050
https://doi.org/10.1093/neuonc/nox050
Autor:
Ralf S. Schmid, C. Ryan Miller, Onyi Okolie, Juli R. Bagó, Shawn Hingtgen, Ryan E. Bash, David M. Irvin
Publikováno v:
Neuro-Oncology. 18:1622-1633
Background Surgical resection is a universal component of glioma therapy. Little is known about the postoperative microenvironment due to limited preclinical models. Thus, we sought to develop a glioma resection and recurrence model in syngeneic immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9a179e88bc4826f3582b55a718ede0
https://doi.org/10.1093/neuonc/now117
https://doi.org/10.1093/neuonc/now117
Publikováno v:
Brain Pathology. 27:36-50
The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b0fdc6807ca28a802eb06bcfebcbdf
https://doi.org/10.1111/bpa.12348
https://doi.org/10.1111/bpa.12348
Autor:
Frank B. Furnari, Steven P. Angus, Noah Sciaky, Ryan Miller, Abigail Shelton, Michael E. Berens, Madison Butler, Gary L. Johnson, Ryan E. Bash, Erin Smithberger, Alex Flores, Harshil Dhruv
Glioblastoma (GBM) has poor survival and lacks effective treatments. Due to frequent amplification and mutation of epidermal growth factor receptor (EGFR), several EGFR tyrosine kinase inhibitors have been trialed, but none have proven successful. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831542740a1cd67572994de62727c5a0
https://europepmc.org/articles/PMC6216460/
https://europepmc.org/articles/PMC6216460/