Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ryan E, Hibbs"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Methaqualone, a quinazolinone marketed commercially as Quaalude, is a central nervous system depressant that was used clinically as a sedative-hypnotic, then became a notorious recreational drug in the 1960s-80s. Due to its high abuse potent
Externí odkaz:
https://doaj.org/article/8723f5304e7842c28dc547bb77ac8025
Autor:
Dagimhiwat H. Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J. Howard, Colleen M. Noviello, Erik Lindahl, Ryan E. Hibbs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract γ-Aminobutyric acid type A (GABAA) receptors mediate fast inhibitory signaling in the brain and are targets of numerous drugs and endogenous neurosteroids. A subset of neurosteroids are GABAA receptor positive allosteric modulators; one of
Externí odkaz:
https://doaj.org/article/9c3fd95d1605447bb8e398d6acc64164
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by potentiating inhibitory ion channels and inhibiting excitatory ion channels, with the ne
Externí odkaz:
https://doaj.org/article/b047f64acf47400ca4ed61908596a965
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GABAA receptors are important targets for anxiety, sedation and anesthesia. Here, the authors present structures bound by zolpidem (Ambien), the most prescribed hypnotic in the US, and DMCM, a negative modulator, providing insights into receptor modu
Externí odkaz:
https://doaj.org/article/8bdf68ac057b4f82838f0620509d6a37
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
As the resolution revolution in CryoEM expands to encompass all manner of macromolecular complexes, an important new frontier is the implementation of cryogenic time resolved EM (cryoTREM). Biological macromolecular complexes are dynamic systems that
Externí odkaz:
https://doaj.org/article/77420cf0a25c45588bee127d55b8db47
Autor:
Guipeun Kang, Corey A. H. Allard, Wendy A. Valencia-Montoya, Lena van Giesen, Jeong Joo Kim, Peter B. Kilian, Xiaochen Bai, Nicholas W. Bellono, Ryan E. Hibbs
Publikováno v:
Nature. 616:378-383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b8572a86a417fc5f06386655e18bbf7
https://doi.org/10.1038/s41586-023-05808-z
https://doi.org/10.1038/s41586-023-05808-z
Autor:
Corey A. H. Allard, Guipeun Kang, Jeong Joo Kim, Wendy A. Valencia-Montoya, Ryan E. Hibbs, Nicholas W. Bellono
Publikováno v:
Nature. 616:373-377
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca98978e16877a2e4273e34afdc9882d
https://doi.org/10.1038/s41586-023-05822-1
https://doi.org/10.1038/s41586-023-05822-1
Autor:
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Publikováno v:
eLife, Vol 9 (2020)
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of liga
Externí odkaz:
https://doaj.org/article/342cb67467c141c1a4b0ebacf9821115
Autor:
Chen Fan, Dagimhiwat Legesse, Yuxuan Zhuang, Reba J. Howard, Colleen M. Noviello, Erik Lindah, Ryan E. Hibbs
Molecular dynamics simulations data of α1β2γ2 GABAAR with positive and negative neurosteriods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39217691769d19325243a3a10feaf2c7
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Molecular dynamics simulations of the alpha-7 nicotinic receptor, both atomistic (ion permeation free energy calculation) and coarse-grained (lipid and drug binding).
Two amino residues were incorrectly assigned in the original PDB file. N35 sho
Two amino residues were incorrectly assigned in the original PDB file. N35 sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e780d5f32423b671cadb81670b64b4df
https://doi.org/10.1073/pnas.2208081119
https://doi.org/10.1073/pnas.2208081119