Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ryan Dorton"'
Autor:
Christopher P. Leamon, Isabelle Dussault, Emmett V. Schmidt, Kristen L. Picard, Andrey Loboda, Theresa Zhang, Michael Nebozhyn, Serguei Lejnine, Marilynn Vetzel, Melissa Nelson, Alicia Bloomfield, Ryan Dorton, Marlene C. Hinton, Brian B. Haines, Razvan Cristescu, Joseph A. Reddy, Alexander Stoeck, Jennifer O'Neil, Amy D. Guertin
Supplementary Figure 1: Assessment of kidney cancer cell lines A498, 786-O, and A704 via flow cytometry revealed surface expression of P-gp in all lines; Supplementary Figure 2: 786-O and A704 cells were transduced with lentiviral FR1, and flow cytom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b3ef96e0e06a8b39939d2f61b13772
https://doi.org/10.1158/1535-7163.22508953
https://doi.org/10.1158/1535-7163.22508953
Autor:
Christopher P. Leamon, Isabelle Dussault, Emmett V. Schmidt, Kristen L. Picard, Andrey Loboda, Theresa Zhang, Michael Nebozhyn, Serguei Lejnine, Marilynn Vetzel, Melissa Nelson, Alicia Bloomfield, Ryan Dorton, Marlene C. Hinton, Brian B. Haines, Razvan Cristescu, Joseph A. Reddy, Alexander Stoeck, Jennifer O'Neil, Amy D. Guertin
Legends for Supplementary Figures 1-4 and Supplementary Tables 1 & 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3039f3b3f096fc558ea35d52fe3d7e9a
https://doi.org/10.1158/1535-7163.22508959
https://doi.org/10.1158/1535-7163.22508959
Autor:
Marilynn Vetzel, Hari Krishna Santhapuram, Christina Dircksen, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Paul J. Kleindl, Melissa Nelson, Joseph A. Reddy, Ryan Dorton, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede75dcf036acc8e8a7c9f4805d63d4
http://link.springer.com/article/10.1038/s41598-018-27320-5
http://link.springer.com/article/10.1038/s41598-018-27320-5
Autor:
Alicia Bloomfield, Iontcho Radoslavov Vlahov, Melissa Nelson, Christopher P. Leamon, Marilynn Vetzel, Kevin Wang, Paul J. Kleindl, Ryan Dorton, Joseph A. Reddy, Spencer Hahn
Publikováno v:
Bioconjugate chemistry. 30(6)
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer, and it is also present on the neovasculature within many non-prostate solid tumors. Herein, we report on the construction and biological testing of nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf3384bbfb6bfe90350c3188a690c09
https://pubmed.ncbi.nlm.nih.gov/31075200
https://pubmed.ncbi.nlm.nih.gov/31075200
Autor:
Kristen L. Picard, Razvan Cristescu, Jennifer O'Neil, Theresa Zhang, Joseph A. Reddy, Melissa Nelson, Marilynn Vetzel, Amy D. Guertin, Andrey Loboda, Serguei Lejnine, Marlene C. Hinton, Emmett V. Schmidt, Alexander Stoeck, Ryan Dorton, Alicia Bloomfield, Isabelle Dussault, Christopher P. Leamon, Michael Nebozhyn, Brian B. Haines
Publikováno v:
Molecular Cancer Therapeutics. 15:1998-2008
Targeting surface receptors overexpressed on cancer cells is one way to specifically treat cancer versus normal cells. Vintafolide (EC145), which consists of folate linked to a cytotoxic small molecule, desacetylvinblastine hydrazide (DAVLBH), takes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca15cd5460db1b0e805ee42bb8d4df1
https://doi.org/10.1158/1535-7163.mct-15-0950
https://doi.org/10.1158/1535-7163.mct-15-0950
Autor:
Elaine Westrick, Ryan Dorton, Hari Krishna Santhapuram, Jeremy F. Vaughn, Melissa Nelson, Paul J. Kleindl, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Joseph A. Reddy, Fei You, Marilynn Vetzel, Christopher P. Leamon
Publikováno v:
Bioconjugate Chemistry. 25:560-568
Vintafolide is a potent folate-targeted vinca alkaloid small molecule drug conjugate (SMDC) that has shown promising results in multiple clinical oncology studies. Structurally, vintafolide consists of 4 essential modules: (1) folic acid, (2) a hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c238990b851d5ca4110974eab055a7
https://doi.org/10.1021/bc400441s
https://doi.org/10.1021/bc400441s
Autor:
Marilynn Vetzel, Christopher P. Leamon, Ryan Dorton, Joseph A. Reddy, Alicia Bloomfield, Mellissa Nelson
Publikováno v:
Cancer Research. 73:P2-16
Triple negative breast cancer (TNBC) is a subtype characterized by lack of gene expression for the estrogen receptor, progesterone receptor and the Her2/neu protein. Hence, the lack of hormonal or Her2 targeted therapy options makes TNBC difficult to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033cf7ff9750ddddac05084dea11860e
https://doi.org/10.1158/0008-5472.sabcs13-p2-16-24
https://doi.org/10.1158/0008-5472.sabcs13-p2-16-24
Autor:
Alicia Bloomfield, Iontcho Radoslavov Vlahov, Christopher P. Leamon, Marilynn Vetzel, Le-Cun Xu, Patrick J. Klein, Joseph A. Reddy, Yu Wang, Elaine Westrick, Ryan Dorton
Publikováno v:
Cancer chemotherapy and pharmacology. 79(6)
EC0305 represents a folate-tubulysin B construct capable of specifically eradicating folate receptor (FR)-positive subcutaneous tumors from mice (Leamon et al., Cancer Res 68:9839–9844, 8). Herein we report on the use of multiple polar carbohydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4aac4f5fb99a7cc79635e19a30a640a
https://pubmed.ncbi.nlm.nih.gov/28451831
https://pubmed.ncbi.nlm.nih.gov/28451831
Autor:
Hari Krishna Santhapuram, Elaine Westrick, Yu Wang, Ryan Dorton, Marilynn Vetzel, Iontcho Radoslavov Vlahov, Joseph A. Reddy, Christopher P. Leamon, Alicia Dawson
Publikováno v:
Molecular Pharmaceutics. 4:659-667
We have designed a new type of tumor-targeted agent by tethering two different drug molecules, with distinct biological mechanisms of action, to the same ligand. This compound, named EC0225, represents the "first in class" multidrug, folate receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90c1c9f93b86b8e450729d755d581ac
https://doi.org/10.1021/mp070049c
https://doi.org/10.1021/mp070049c
Autor:
Elaine Westrick, Ryan Dorton, Alicia Dawson, Terri Smith, Paul J. Kleindl, Le-Cun Xu, Christopher P. Leamon, Marilynn Vetzel, Iontcho Radoslavov Vlahov, Joseph A. Reddy
Publikováno v:
Cancer Research. 67:4434-4442
We recently developed a new group of folate-conjugated Vinca alkaloids, one of which, EC145, emerged as a candidate for clinical development. Brief treatment of nude mice bearing ∼100 mm3 folate receptor-positive human xenografts led to complete re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cc06e37c8deaa8dd4883d2e3ded347
https://doi.org/10.1158/0008-5472.can-07-0033
https://doi.org/10.1158/0008-5472.can-07-0033