Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ryan Demeter"'
Autor:
Andrew E O Hughes, Vincent Magrini, Ryan Demeter, Christopher A Miller, Robert Fulton, Lucinda L Fulton, William C Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F Conrad, Brian S White, Jin Shao, Daniel C Link, John F DiPersio, Elaine R Mardis, Richard K Wilson, Timothy J Ley, Matthew J Walter, Timothy A Graubert
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004462 (2014)
Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-w
Externí odkaz:
https://doaj.org/article/1777fa4a2cbc4a6098dfc41effa04000
Autor:
Beatriz M. Carreno, Zachary L. Skidmore, Michelle Becker-Hapak, David H. Spencer, Alexander S. Krupnick, Vincent Magrini, Maya G. Robnett, Obi L. Griffith, Ryan Demeter, Saghar Kaabinejadian, Casey L. Cummins, Gerald P. Linette, Weixuan Fu, Chong Xu, Elaine R. Mardis, William H. Hildebrand, Miren L. Baroja, Jasreet Hundal, Malachi Griffith
Publikováno v:
Proc Natl Acad Sci U S A
The impact of intratumoral heterogeneity (ITH) and the resultant neoantigen landscape on T cell immunity are poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of effective t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4fe3d14bce2be3ea8df24b79023bd4
https://doi.org/10.1073/pnas.1906026116
https://doi.org/10.1073/pnas.1906026116
Autor:
Patrick J. Lau, Ashley Dvorak, Kevin Lai, Ryan Demeter, Shale Dames, Steven Henck, Katia Star, Katelyn Larkin, Bosun Min, Timothy Barnes, Manqing Hong, Jessica Sheu, Hsiao-Yun Huang, Ushati Das Chakravarty, Tzu-Chun Chen
Publikováno v:
Cancer Research. 81:327-327
RNA-seq is a powerful tool to detect tissue-specific gene expression, splicing, and genetic variations associated with disease states. However, current RNA-seq approaches have limitations due to poor signal from low-abundant transcripts. Furthermore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::925526f1a1236da912f8b11b352c5054
https://doi.org/10.1158/1538-7445.am2021-327
https://doi.org/10.1158/1538-7445.am2021-327
Autor:
Timothy J. Ley, Ryan Demeter, David E. Larson, Vincent Magrini, Ha X. Dang, Elaine R. Mardis, Jason Walker, Christopher A. Miller, Malachi Griffith, Obi L. Griffith, Robert S. Fulton, Zachery L. Skidmore, Christopher G. Maher, Avinash Ramu, Richard K. Wilson
Publikováno v:
Cancer Research. 75:A1-13
Most tumors are heterogeneous, and the presence of distinct subclonal populations has been shown to be common in every type of cancer assayed to date. Even very low-frequency populations may harbor mutations that offer a selective advantage during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34172911efabd78b155dc4124a665598
https://doi.org/10.1158/1538-7445.transcagen-a1-13
https://doi.org/10.1158/1538-7445.transcagen-a1-13
Autor:
Jeffery M. Klco, Matthew J. Walter, Richard K. Wilson, Tamara Lamprecht, William C. Eades, Ryan Demeter, Malachi Griffith, Elaine R. Mardis, Robert S. Fulton, John F. DiPersio, Timothy A. Graubert, Michelle O'Laughlin, Catrina Fronick, Christopher A. Miller, David H. Spencer, Daniel C. Link, Timothy J. Ley, Vincent Magrini
Publikováno v:
Cancer Cell. 25:379-392
SummaryThe relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole-genome sequencing using a variety of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b04b63884d90af83f4020795b80cc33
https://doi.org/10.1016/j.ccr.2014.01.031
https://doi.org/10.1016/j.ccr.2014.01.031
Autor:
Katherine A. Hoadley, Charles M. Perou, Joel S. Parker, Michael C. Wendl, Lisa A. Carey, Richard K. Wilson, Wei Zhao, Xiaping He, Marni B. Siegel, Elaine R. Mardis, Krishna L. Kanchi, Li Ding, Ryan Demeter, Christopher A. Miller, Robert S. Fulton
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002174 (2016)
PLoS Medicine
PLoS Medicine
Background Metastasis is the main cause of cancer patient deaths and remains a poorly characterized process. It is still unclear when in tumor progression the ability to metastasize arises and whether this ability is inherent to the primary tumor or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc48156dff708eca5d30ef8c670046
http://europepmc.org/articles/PMC5140046?pdf=render
http://europepmc.org/articles/PMC5140046?pdf=render
Autor:
Christopher A. Miller, Ian S. Hagemann, Peter Westervelt, Obi L. Griffith, Vincent Magrini, Lukas D. Wartman, Peter A. Riedell, Michelle O'Laughlin, Bradley A. Ozenberger, Malachi Griffith, Charles Lu, Eric J. Duncavage, Ryan Demeter
Publikováno v:
Cold Spring Harbor Molecular Case Studies
We report the findings from a patient who presented with a concurrent mediastinal germ cell tumor (GCT) and acute myeloid leukemia (AML). Bone marrow pathology was consistent with a diagnosis of acute megakaryoblastic leukemia (AML M7), and biopsy of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625c1d7d86b3cffb0f214dd67156b704
http://europepmc.org/articles/PMC4849848
http://europepmc.org/articles/PMC4849848
Autor:
Li-Wei Chang, Karla V. Ballman, Sandra McDonald, Matthew J. Ellis, Chris Harris, Timothy J. Ley, Reece J. Goiffon, David Piwnica-Worms, Li Lin, Mark A. Watson, David J. Dooling, David M. Ota, William Schierding, Ken Chen, Gary Unzeitig, Feiyu Du, Ben Oberkfell, Ron Bose, P. Kelly Marcom, John W. Wallis, Jason D. Weber, Dong Shen, Sam Ng, Cyriac Kandoth, Charles Lu, J. M. Guenther, Vera J. Suman, Elaine R. Mardis, Tammi L. Vickery, Helen Piwnica-Worms, Laura J. Esserman, Jeremy Hoog, Robert J. Crowder, Lucinda Fulton, Yu Tao, Christopher A. Miller, Gildy Babiera, Joshua F. McMichael, Theodore C. Goldstein, Adnan Elhammali, Joshua M. Stuart, Richard K. Wilson, Brian A. Van Tine, Michael C. Wendl, Robert S. Fulton, Li Ding, Ryan Demeter, Jacqueline E. Snider, Julie A. Margenthaler, John A. Olson, Michelle Harrison, D. Craig Allred, Katherine DeSchryver, Jingqin Luo, Marilyn Leitch, Christopher G. Maher, Michael D. McLellan, Kelly K. Hunt, Daniel C. Koboldt
Publikováno v:
Nature
Summary To correlate the variable clinical features of estrogen receptor positive (ER+) breast cancer with somatic alterations, we studied pre-treatment tumour biopsies accrued from patients in a study of neoadjuvant aromatase inhibitor (AI) therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e662efd52198c84afc976af33f07d033
http://europepmc.org/articles/PMC3383766
http://europepmc.org/articles/PMC3383766
Autor:
Anthony Leotta, Steven Marks, Ivan Iossifov, Lucinda Fulton, Kith Pradhan, Peter Andrews, Linda Rodgers, Michael Wigler, Beicong Ma, Richard W. McCombie, Jennifer Troge, Elena Ghiban, Ryan Demeter, Robert S. Fulton, Julie Rosenbaum, Asya Stepansky, Vincent Magrini, Yoon-ha Lee, Kenny Ye, Jennifer Parla, Richard K. Wilson, Robert B. Darnell, Boris Yamrom, Inessa Hakker, Jennifer C. Darnell, Michael Ronemus, Michael C. Schatz, Dan Levy, Elaine R. Mardis, Zihua Wang, Giuseppe Narzisi, Melissa Kramer, Jude Kendall, Mitchell A. Bekritsky, Ewa A. Grabowska
Publikováno v:
Neuron. 74(2):285-299
SummaryExome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveal de novo small indels and point substitutions, which come mostly from the paternal line in an age-dependent manner. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436dac00dfb388b306cc1884918b76cf
Autor:
Mark J. Smyth, Charles G. Rickert, J. Michael White, Robert D. Schreiber, Vincent Magrini, Yee Shiuan Chen, Cora D. Arthur, Jasreet Hundal, Lloyd J. Old, Todd Wylie, Hirokazu Matsushita, Ravindra Uppaluri, Michael C. Wendl, Matthew D. Vesely, Lauren Shea, Ryan Demeter, James P. Allison, Elaine R. Mardis, Daniel C. Koboldt
Publikováno v:
Nature. 482:400-404
Cancer immunoediting, the process by which the immune system controls tumour outgrowth and shapes tumour immunogenicity, is comprised of three phases: elimination, equilibrium and escape. Although many immune components that participate in this proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491d111510cd64263e6cd96f10510339
https://doi.org/10.1038/nature10755
https://doi.org/10.1038/nature10755