Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Ryan D. Roberts"'
Autor:
Jack Hedberg, Adam Studebaker, Luke Smith, Chun-Yu Chen, Jesse J. Westfall, Maren Cam, Amy Gross, Ilse Hernandez-Aguirre, Alexia Martin, Doyeon Kim, Ravi Dhital, Yeaseul Kim, Ryan D. Roberts, Timothy P. Cripe, Elaine R. Mardis, Kevin A. Cassady, Jeffrey Leonard, Katherine E. Miller
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 39-55 (2023)
Oncolytic viruses, modified for tumor-restricted infection, are a promising cancer immunotherapeutic, yet much remains to be understood about factors driving their activity and outcome in the tumor microenvironment. Here, we report that oncolytic her
Externí odkaz:
https://doaj.org/article/4ec2f4c531974d0cbbb997bdf92d6293
Autor:
Rituraj Upadhyay, Brett Klamer, Jennifer Matsui, Vikram B. Chakravarthy, Thomas Scharschmidt, Nicholas Yeager, Bhuvana A. Setty, Timothy P. Cripe, Ryan D. Roberts, Jennifer H. Aldrink, Raj Singh, Raju R. Raval, Joshua D. Palmer, Sujith Baliga
Publikováno v:
Cancers, Vol 16, Iss 11, p 2090 (2024)
Background: Pediatric patients with metastatic and/or recurrent solid tumors have poor survival outcomes despite standard-of-care systemic therapy. Stereotactic ablative radiation therapy (SABR) may improve tumor control. We report the outcomes with
Externí odkaz:
https://doaj.org/article/c5c789d8e4434b19825466c798b94920
Autor:
Sanjana Rajan, Emily M. Franz, Camille A. McAloney, Tatyana A. Vetter, Maren Cam, Amy C. Gross, Cenny Taslim, Meng Wang, Matthew V. Cannon, Alexander Oles, Ryan D. Roberts
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Tumors are complex tissues containing collections of phenotypically diverse malignant and nonmalignant cells. We know little of the mechanisms that govern heterogeneity of tumor cells nor of the role heterogeneity plays in overcom
Externí odkaz:
https://doaj.org/article/f3bd873dccee4b43a8ac192346072f84
Autor:
David S. Shulman, Sarah B. Whittle, Didier Surdez, Kelly M. Bailey, Enrique de Álava, Jason T. Yustein, Adam Shlien, Masanori Hayashi, Alexander J. R. Bishop, Brian D. Crompton, Steven G. DuBois, Neerav Shukla, Patrick J. Leavey, Stephen L. Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G. P. Grünewald, Cristina R. Antonescu, Ryan D. Roberts, Jeffrey A. Toretsky, Franck Tirode, Richard Gorlick, Katherine A. Janeway, Damon Reed, Elizabeth R. Lawlor, Patrick J. Grohar
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60–80% of patien
Externí odkaz:
https://doaj.org/article/85d5d49a92054aefa68b0e44c262da64
Autor:
Sakthi Rajendran, Yang Hu, Alessandro Canella, Clayton Peterson, Amy Gross, Maren Cam, Matthew Nazzaro, Abigail Haffey, Akdes Serin-Harmanci, Rosario Distefano, Giovanni Nigita, Wesley Wang, Daniel Kreatsoulas, Zihai Li, Jesse A. Sepeda, Andrew Sas, Mark E. Hester, Katherine E. Miller, Olivier Elemento, Ryan D. Roberts, Eric C. Holland, Ganesh Rao, Elaine R. Mardis, Prajwal Rajappa
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112197- (2023)
Summary: Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate immunosuppression in glioma; however, it is still unclear if myeloid cells p
Externí odkaz:
https://doaj.org/article/4c475f0d1a224421a34de4bf6fa862d6
Publikováno v:
Cancers, Vol 15, Iss 20, p 4970 (2023)
Osteosarcoma (OS) is the most common primary bone malignancy that exhibits remarkable histologic diversity and genetic heterogeneity. The complex nature of osteosarcoma has confounded precise molecular categorization, prognosis, and prediction for th
Externí odkaz:
https://doaj.org/article/66581cda97a641f29b358c59246d3bcc
Autor:
Brian Hutzen, Mohammed Ghonime, Joel Lee, Elaine R. Mardis, Ruoning Wang, Dean A. Lee, Mitchell S. Cairo, Ryan D. Roberts, Timothy P. Cripe, Kevin A. Cassady
Publikováno v:
Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 38-48 (2019)
Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers s
Externí odkaz:
https://doaj.org/article/36af620670ea4aae9d7d981fa9e79e75
Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma
Autor:
Mary Frances Wedekind, Katherine E. Miller, Chun-Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Mark A. Currier, Brooke Nartker, Ryan D. Roberts, Louis Boon, Joe Conner, Stephanie LaHaye, Benjamin J. Kelly, David Gordon, Peter White, Elaine R. Mardis, Timothy P. Cripe
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102759- (2021)
Summary: Osteosarcoma remains one of the deadliest cancers in pediatrics and young adults. We administered two types of immunotherapies, oncolytic virotherapy and immune checkpoint inhibition, to two murine osteosarcoma models and observed divergent
Externí odkaz:
https://doaj.org/article/42684aaa1ef54305b26e4df761b4bd3f
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor cells with osteoblastic differentiation and osteoid production. While categorized as a rare tumor, most patients diagnosed with osteosarcoma are adolescents in the
Externí odkaz:
https://doaj.org/article/b6f1a0df81d247859fdae0aceac0e9a5
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Patients who develop osteosarcoma in 2017 receive treatment that remains essentially unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large, collaborative, multinational efforts to improve therapy have evaluated strategies leve
Externí odkaz:
https://doaj.org/article/3e1764ddf0db4ce6b32db0c58d5a82de