Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ryan D, Makin"'
Autor:
Peirong Huang, Claire C. Thomas, Kameshwari Ambati, Roshni Dholkawala, Ayami Nagasaka, Praveen Yerramothu, Siddharth Narendran, Felipe Pereira, Yosuke Nagasaka, Ivana Apicella, Xiaoyu Cai, Ryan D. Makin, Joseph Magagnoli, Cliff I. Stains, Ruwen Yin, Shao-bin Wang, Bradley D. Gelfand, Jayakrishna Ambati
Publikováno v:
Investigative Opthalmology & Visual Science. 64:3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1430eb3d8ddd98410e7507689a9bb64a
https://doi.org/10.1167/iovs.64.5.3
https://doi.org/10.1167/iovs.64.5.3
Autor:
Shuichiro Hirahara, Tetsuro Oshika, Siddharth Narendran, J. Ignacio Aguirre, Shinichi Fukuda, Meenakshi Ambati, Benjamin J. Fowler, Praveen Yerramothu, Bradley D. Gelfand, David R. Hinton, Jayakrishna Ambati, Gerald G. Schumann, Ulrike Held, Yosuke Nagasaka, Felipe Pereira, Kirstie Baker, Nagaraj Kerur, Srinivas R. Sadda, Sanford H. Feldman, Shaobin Wang, Akhil Varshney, Peirong Huang, Ryan D. Makin, Kameshwari Ambati, Vera L. Bonilha, Mo Wang, Tetsuhiro Yasuma, Reo Yasuma, Vidya L. Ambati, Elmira Baghdasaryan, Xiwen Huang, Hiroko Terasaki, Daipayan Banerjee, Ivana Apicella, Kenneth M. Marion, Genrich V. Tolstonog, Yuichiro Ogura, Deepak Bhattarai, Kyung Bo Kim
Publikováno v:
Science advances, 7(40):eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Description
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76950f2faadbc056f974ac06c1a507
https://doi.org/10.1126/sciadv.abj3658
https://doi.org/10.1126/sciadv.abj3658
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab56470358e690f442ac6be149dcb9
https://doi.org/10.1073/pnas.2022751118
https://doi.org/10.1073/pnas.2022751118
Autor:
Bradley D. Gelfand, Nagaraj Kerur, Yosuke Nagasaka, Ambati Balamurali K, Shinichi Fukuda, Jayakrishna Ambati, Charles B. Wright, Benjamin J. Fowler, Bo Chang, Tetsuhiro Yasuma, Siddharth Narendran, Izuho Hatada, Reo Yasuma, Philippe Georgel, Ana Bastos-Carvalho, Felipe Pereira, Romulo Albuquerque, Younghee Kim, Shuichiro Hirahara, Ivana Apicella, Hironori Uehara, Ryan D. Makin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29a87b487442fdc8a37ed197e2b940e
https://pubmed.ncbi.nlm.nih.gov/31964819
https://pubmed.ncbi.nlm.nih.gov/31964819
Autor:
Ryan D. Makin, Colleen M. Cebulla, Tyler Heisler-Taylor, Huan Yang, Lian-Wang Guo, Hongtao Shen, Bradley D. Gelfand, Timur A. Mavlyutov, Jing Li
Publikováno v:
Cell Signal
The retinal pigment epithelium (RPE) is critical to the survival of the overlying photoreceptors. Subject to light exposure and active metabolism, the RPE and photoreceptors are particularly susceptible to oxidative damage that plays an important par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc25921d14da7757a8cee7cf24a33b92
https://doi.org/10.1016/j.cellsig.2021.110078
https://doi.org/10.1016/j.cellsig.2021.110078
Autor:
Yosuke Nagasaka, Bradley D. Gelfand, Hiroki Kaneko, Ivana Apicella, Ryan D. Makin, Stephen D. Turner, Nagaraj Kerur, Jayakrishna Ambati
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The misuse of inauthentic cell lines is widely recognized as a major threat to the integrity of biomedical science. Whereas the majority of efforts to address this have focused on DNA profiling, we sought to anatomically, transcriptionally, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fb715e61c7b22ff33345c9e240f174
https://doi.org/10.1167/iovs.18-25215
https://doi.org/10.1167/iovs.18-25215