Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ryan C Widau"'
Autor:
Guoliang Shao, Yuxian Bai, Xianglin Yuan, Xiaomin Chen, Shanzhi Gu, Kangsheng Gu, Chunhong Hu, Houjie Liang, Yabing Guo, Jufeng Wang, Chia-Jui Yen, Victor Ho-Fun Lee, Chunxiao Wang, Ryan C. Widau, Wanli Zhang, Junjun Liu, Qiang Zhang, Shukui Qin
Publikováno v:
EClinicalMedicine, Vol 54, Iss , Pp 101679- (2022)
Summary: Background: In the global REACH-2 study, ramucirumab significantly improved overall survival (OS) compared with placebo in patients with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP). REACH-2 China study aimed
Externí odkaz:
https://doaj.org/article/e806fe3c322947ce9fe7c571dbf725cc
Autor:
Masatoshi Kudo, Richard S. Finn, Manabu Morimoto, Kun-Ming Rau, Masafumi Ikeda, Chia-Jui Yen, Peter R. Galle, Josep M. Llovet, Bruno Daniele, Ho Yeong Lim, David W. McIlwain, Reigetsu Yoshikawa, Kenichi Nakamura, Kun Liang, Chunxiao Wang, Paolo Abada, Ryan C. Widau, Andrew X. Zhu
Publikováno v:
Liver Cancer, Pp 1-10 (2021)
Background: Intermediate-stage hepatocellular carcinoma (HCC), as defined by Barcelona Clinic Liver Cancer (BCLC) stage B, is heterogeneous in terms of liver function and tumor burden. REACH and REACH-2 investigated ramucirumab in patients with HCC a
Externí odkaz:
https://doaj.org/article/45c831adde1a42d0a4519ec7cc5d2877
Autor:
Masatoshi Kudo, Peter R. Galle, Giovanni Brandi, Yoon-Koo Kang, Chia-Jui Yen, Richard S. Finn, Josep M. Llovet, Eric Assenat, Philippe Merle, Stephen L. Chan, Daniel H. Palmer, Masafumi Ikeda, Tatsuya Yamashita, Arndt Vogel, Yi-Hsiang Huang, Paolo B. Abada, Reigetsu Yoshikawa, Kenta Shinozaki, Chunxiao Wang, Ryan C. Widau, Andrew X. Zhu
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100215- (2021)
Background & Aims: The albumin–bilirubin (ALBI) grade/score is derived from a validated nomogram to objectively assess prognosis and liver function in patients with hepatocellular carcinoma (HCC). In this post hoc analysis, we assessed prognosis in
Externí odkaz:
https://doaj.org/article/f21c0213c7ba4e8f9aaf4f20a9254ea2
Autor:
Andrew X. Zhu, Elena Gonzalez-Gugel, Ryan C. Widau, Paolo Abada, Chunxiao Wang, Louise M. McGrath, Sophie Callies, Masafumi Ikeda, Peter R. Galle, Masatoshi Kudo, Richard S. Finn, Augusto Villanueva, Amit G. Singal, Josep M. Llovet
Supplementary Table from Prognostic and Predictive Factors in Patients with Advanced HCC and Elevated Alpha-Fetoprotein Treated with Ramucirumab in Two Randomized Phase III Trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042489455dee271c751f57309d7e387b
https://doi.org/10.1158/1078-0432.22486710
https://doi.org/10.1158/1078-0432.22486710
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
(A) Quantification of bands from Western gel shown in Main Figure 3A using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-G) Clonogenic survival o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c91028c76ea48a7af241d56469ca53f
https://doi.org/10.1158/0008-5472.22423802
https://doi.org/10.1158/0008-5472.22423802
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
(A) Quantification of bands from Western gel shown in Main Figure 5D using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-E) Kinetic analysis of W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bc85bcb68b6b50eb309456ae05d6c4
https://doi.org/10.1158/0008-5472.22423787.v1
https://doi.org/10.1158/0008-5472.22423787.v1
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
(A-D) Quantification of bands from Western gels shown in Main Figures 3H (A), 3I (B), 3J (C), and 3K (D) using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22bb8269581573bae51c00a234fc886
https://doi.org/10.1158/0008-5472.22423799.v1
https://doi.org/10.1158/0008-5472.22423799.v1
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
WT and STING-/- MEFs examined by cytokinesis-block micronucleus (CBMN) assay by treatment with IR, then cytochalasin at 24 hours and then fixed and stained for DNA and mitochondrial/cytoplasmic compartments using Draq5 and MitoTracker Red at 48 hours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ce72cbd009f095d6431b46b6d310e5
https://doi.org/10.1158/0008-5472.22423793
https://doi.org/10.1158/0008-5472.22423793
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
(A-C) BrdU/PI cell cycle profile of MEFs (A), p53-/- HCT116 (B), and CDKN1A-depleted HCT116 cells (C) at 24 hours post-IR. Flow cytometry was used to measure the percent cell population in G1, S, and G2/M phase of single cells stained with FITC-conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0318fc602b5256c27fd73b12debf58c9
https://doi.org/10.1158/0008-5472.22423790
https://doi.org/10.1158/0008-5472.22423790
Autor:
Ralph R. Weichselbaum, Nikolai N. Khodarev, George-Lucian Moldovan, Stephen J. Kron, Renate Parry, Ainhoa Arina, Michael J. Bolt, Xiaona Huang, Claudia M. Nicolae, Akash D. Parekh, Stephen Mallon, Ryan C. Widau, Diana Rose E. Ranoa
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to primarily affect antitumor immunity. Here we demonstrate a role for STING in the maintenance of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7eca93a436663f8ce8eb450b16eab2e
https://doi.org/10.1158/0008-5472.c.6511583.v1
https://doi.org/10.1158/0008-5472.c.6511583.v1