Výsledky vyhledávání - "Ryan C Riddle"

Akademický článek

Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1.

Autor: Christine W Gao, WanYing Lin, Ryan C Riddle, Sheetal Chopra, Jiyoung Kim, Leandros Boukas, Kasper D Hansen, Hans T Björnsson, Jill A Fahrner

Publikováno v: PLoS Genetics, Vol 20, Iss 6, p e1011310 (2024)

Growth deficiency is a characteristic feature of both Kabuki syndrome 1 (KS1) and Kabuki syndrome 2 (KS2), Mendelian disorders of the epigenetic machinery with similar phenotypes but distinct genetic etiologies. We previously described skeletal growt

Externí odkaz: https://doaj.org/article/4bc73b4b5abe410a8220e06884a74d73

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Akademický článek

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

Autor: Dylan C Sarver, Jean Garcia-Diaz, Muzna Saqib, Ryan C Riddle, G William Wong

Publikováno v: eLife, Vol 12 (2024)

Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes, TMEM263, encodes a poorly characterized plasma membrane protein. Single

Externí odkaz: https://doaj.org/article/79f38225ad9b44c9aba3a5a68c278bad

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Akademický článek

Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

Autor: Ryan C Riddle, Cassandra R Diegel, Julie M Leslie, Kyle K Van Koevering, Marie-Claude Faugere, Thomas L Clemens, Bart O Williams

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63323 (2013)

The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the precise roles of the individual Wnt co-receptors, Lrp5 and Lrp6, that enable Wnt signals to be transmitted in osteoblasts remain controversial. In these

Externí odkaz: https://doaj.org/article/f800c6322c8f4019a916fd0d6a4d0983

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Akademický článek

Dual Effects of Lipid Metabolism on Osteoblast Function

Autor: Nathalie S. Alekos, Megan C. Moorer, Ryan C. Riddle

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

The skeleton is a dynamic and metabolically active organ with the capacity to influence whole body metabolism. This newly recognized function has propagated interest in the connection between bone health and metabolic dysfunction. Osteoblasts, the sp

Externí odkaz: https://doaj.org/article/c8be1d63328844c28491a74feed01690

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Akademický článek

Regulation of Osteoblast Metabolism by Wnt Signaling

Autor: Megan C. Moorer, Ryan C. Riddle

Publikováno v: Endocrinology and Metabolism, Vol 33, Iss 3, Pp 318-330 (2018)

Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing bone matrix. Recent studies suggest

Externí odkaz: https://doaj.org/article/636134efb9ac445c82cc702ba4a264f5

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Akademický článek

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Autor: Jieun Lee, Joseph Choi, Ebru S. Selen Alpergin, Liang Zhao, Thomas Hartung, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang

Publikováno v: Cell Reports, Vol 20, Iss 3, Pp 655-667 (2017)

The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis. To understand the role of hepatic fatty acid oxidation in response to a chronic hi

Externí odkaz: https://doaj.org/article/c73aa90a671447a48a51af11143fff4a

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