Assembly of capsids from hepatitis B virus core protein progresses through highly populated intermediates in the presence and absence of RNA

Autor: Ryan C. Oliver, Ingemar André, Najet Mahmoudi, Seyed Morteza Najibi, Lise Arleth, Martin Nors Pedersen, Wojciech Potrzebowski

Publikováno v: 'ACS Nano ', vol: 14, pages: 10226-10238 (2020)
ACS Nano
Oliver, R C, Potrzebowski, W, Najibi, S M, Pedersen, M N, Arleth, L, Mahmoudi, N & Andre, I 2020, ' Assembly of Capsids from Hepatitis B Virus Core Protein Progresses through Highly Populated Intermediates in the Presence and Absence of RNA ', ACS Nano, vol. 14, no. 8, pp. 10226-10238 . https://doi.org/10.1021/acsnano.0c03569

The genetic material of viruses is protected by protein shells that are assembled from a large number of subunits in a process that is efficient and robust. Many of the mechanistic details underpinning efficient assembly of virus capsids are still un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb25d3485836ecb98513db40892147e
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:56200

Small-Angle Scattering as a Structural Probe for Nucleic Acid Nanoparticles (NANPs) in a Dynamic Solution Environment

Autor: Alanna M. Hutchinson-Lundy, Kirill A. Afonin, Joanna K. Krueger, Ryan C. Oliver, Lewis A. Rolband

Publikováno v: Nanomaterials, Vol 9, Iss 5, p 681 (2019)
Nanomaterials

Nucleic acid-based technologies are an emerging research focus area for pharmacological and biological studies because they are biocompatible and can be designed to produce a variety of scaffolds at the nanometer scale. The use of nucleic acids (ribo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b047a5b3f6dacd80fb523c8cc3686c
https://www.mdpi.com/2079-4991/9/5/681

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling

Autor: Swe-Htet Naing, Kevin L. Weiss, Raquel L. Lieberman, Sai Venkatesh Pingali, Volker S. Urban, Ryan C. Oliver

Publikováno v: Journal of Visualized Experiments.

The biological small-angle neutron scattering instrument at the High-Flux Isotope Reactor of Oak Ridge National Laboratory is dedicated to the investigation of biological materials, biofuel processing, and bio-inspired materials covering nanometer to

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https://doi.org/10.3791/57901

Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering

Autor: Raquel L. Lieberman, Ryan C. Oliver, Volker S. Urban, Swe-Htet Naing, Kevin L. Weiss

Publikováno v: Biophysical Journal

Intramembrane aspartyl proteases (IAPs) comprise one of four families of integral membrane proteases that hydrolyze substrates within the hydrophobic lipid bilayer. IAPs include signal peptide peptidase, which processes remnant signal peptides from n

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Designing Mixed Detergent Micelles for Uniform Neutron Contrast

Autor: Sai Venkatesh Pingali, Ryan C. Oliver, Volker S. Urban

Publikováno v: The Journal of Physical Chemistry Letters

Micelle-forming detergents provide an amphipathic environment that mimics lipid bilayers and are important tools used to solubilize and stabilize membrane proteins in solution for in vitro structural investigations. Small-angle neutron scattering (SA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0d5a16241faf6c87336ecb282a4755