Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ryan C Burdick"'
Autor:
Samantha J Ziegler, Chang Liu, Mark Landau, Olga Buzovetsky, Belete A Desimmie, Qi Zhao, Tomoaki Sasaki, Ryan C Burdick, Vinay K Pathak, Karen S Anderson, Yong Xiong
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0195048 (2018)
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 (A3) proteins are a family of cytidine deaminases that catalyze the conversion of deoxycytidine (dC) to deoxyuridine (dU) in single-stranded DNA (ssDNA). A3 proteins act in the i
Externí odkaz:
https://doaj.org/article/2b44dac4d7904f1fa562beeed7f8b801
Autor:
Ryan C Burdick, Krista A Delviks-Frankenberry, Jianbo Chen, Sanath K Janaka, Jaya Sastri, Wei-Shau Hu, Vinay K Pathak
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006570 (2017)
The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated
Externí odkaz:
https://doaj.org/article/bb2dd54645f54d17b26443ba37bf78bb
Autor:
Krista A Delviks-Frankenberry, Olga A Nikolaitchik, Ryan C Burdick, Robert J Gorelick, Brandon F Keele, Wei-Shau Hu, Vinay K Pathak
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005646 (2016)
Although the predominant effect of host restriction APOBEC3 proteins on HIV-1 infection is to block viral replication, they might inadvertently increase retroviral genetic variation by inducing G-to-A hypermutation. Numerous studies have disagreed on
Externí odkaz:
https://doaj.org/article/428a68681d7145479007e4af3b0b6c1d
Autor:
Anton N Chikaev, Anastasiya Yu Bakulina, Ryan C Burdick, Larisa I Karpenko, Vinay K Pathak, Alexander A Ilyichev
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120847 (2015)
The ability to induce anti-HIV-1 antibodies that can neutralize a broad spectrum of viral isolates from different subtypes seems to be a key requirement for development of an effective HIV-1 vaccine. The epitopes recognized by the most potent broadly
Externí odkaz:
https://doaj.org/article/646a0a2d9c6c4962a59a63a2622fd2f7
Autor:
Ryan C. Burdick, Vinay K. Pathak
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/4c4e76f201a7472e9a742a2f8965b944
Autor:
Ryan C. Burdick, Vinay K. Pathak, Wei-Shau Hu, MohamedHusen Munshi, Jonathan M. O. Rawson, Chenglei Li, Kunio Nagashima
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance For several decades, retroviral core uncoating has been thought to occur in the cytoplasm in coordination with reverse transcription, and while some recent studies have concluded that HIV-1 uncoating occurs at the nuclear envelope during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ce1f643596cb110f3c63162df7f69f
http://europepmc.org/articles/PMC7071919
http://europepmc.org/articles/PMC7071919
Publikováno v:
mBio
The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc606b416c745998ff889b57986fd581
https://doi.org/10.1128/mbio.03256-21
https://doi.org/10.1128/mbio.03256-21
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Here, we used a fluorescent protein that is free in solution and is trapped in nuclear HIV-1 capsids to demonstrate that the capsids retain integrity and prevent mixing of macromolecules within the viral core and the cellular environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310bd834278fda32717555f927a5fe91
https://doi.org/10.1073/pnas.2019467118
https://doi.org/10.1073/pnas.2019467118
Autor:
Vinay K. Pathak, Steven C. Hatch, Jianbo Chen, Stephen J. Lockett, Christopher J. Westlake, Ryan C. Burdick, De Chen, Wei-Shau Hu, Luca Sardo, Olga A. Nikolaitchik
Publikováno v:
Journal of Virology. 89:10832-10840
To increase our understanding of the events that lead to HIV-1 genome packaging, we examined the dynamics of viral RNA and Gag-RNA interactions near the plasma membrane by using total internal reflection fluorescence microscopy. We labeled HIV-1 RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fd47221a02d268ee4a41caa4e85f74
https://doi.org/10.1128/jvi.01146-15
https://doi.org/10.1128/jvi.01146-15
Autor:
Wei-Shau Hu, Louis Levine, Ryan C. Burdick, Andrea Galli, Kari A. Dilley, Vinay K. Pathak, Olga A. Nikolaitchik, Kelvin Li, Alan Rein
Publikováno v:
Journal of Virology. 91
Most HIV-1 virions contain two copies of full-length viral RNA, indicating that genome packaging is efficient and tightly regulated. However, the structural protein Gag is the only component required for the assembly of noninfectious viruslike partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da4dd7c3295b093d61c4116aaa32d9b
https://doi.org/10.1128/jvi.02319-16
https://doi.org/10.1128/jvi.02319-16