Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ryan C Brennick"'
Autor:
Elizabeth I. Buchbinder, Jason L. Weirather, Michael Manos, Brian J. Quattrochi, Lynette M. Sholl, Ryan C. Brennick, Peter Bowling, Nancy Bailey, Lisa Magarace, Patrick A. Ott, Rizwan Haq, Benjamin Izar, Anita Giobbie‐Hurder, F. Stephen Hodi
Publikováno v:
Cancer Medicine, Vol 10, Iss 8, Pp 2627-2635 (2021)
Abstract Mucosal melanoma is a rare form of melanoma which arises from melanocytes in the mucosal membranes and can be effectively treated with immune checkpoint blockade (ICB). However, response rates in mucosal melanoma are lower than those observe
Externí odkaz:
https://doaj.org/article/24cb2e96d164402e9d316cff9ef36d9a
Autor:
Jonathan D. Schoenfeld, F. Stephen Hodi, Scott J. Rodig, Alexander Spektor, Srinika Ranasinghe, Jason L. Weirather, James Lindsay, Kathleen L. Pfaff, Mariano Severgnini, Alexander A. Merleev, Alina I. Marusina, Emanual Maverakis, Sacha Gnjatic, Seunghee Kim-Schulze, Adrian Mariño-Enríquez, Mansoor M. Ahmed, Helen X. Chen, Howard Streicher, May Cho, Harvey J. Mamon, Elad Sharon, James M. Cleary, Osama E. Rahma, Olatunji B. Alese, Salma K. Jabbour, Anteneh Tesfaye, Ryan D. Gentzler, Claire Manuszak, Katrina Z. Kao, Ryan C. Brennick, Emily M. Thrash, Ana Lako, Anita Giobbie-Hurder, Arta M. Monjazeb
Purpose:Prospective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4 blockade.Patients and Methods:We performed a multicenter phase II study randomly assig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103e97861a6db4ad698277b2b002fe60
https://doi.org/10.1158/1078-0432.c.6531336
https://doi.org/10.1158/1078-0432.c.6531336
Autor:
Jonathan D. Schoenfeld, F. Stephen Hodi, Scott J. Rodig, Alexander Spektor, Srinika Ranasinghe, Jason L. Weirather, James Lindsay, Kathleen L. Pfaff, Mariano Severgnini, Alexander A. Merleev, Alina I. Marusina, Emanual Maverakis, Sacha Gnjatic, Seunghee Kim-Schulze, Adrian Mariño-Enríquez, Mansoor M. Ahmed, Helen X. Chen, Howard Streicher, May Cho, Harvey J. Mamon, Elad Sharon, James M. Cleary, Osama E. Rahma, Olatunji B. Alese, Salma K. Jabbour, Anteneh Tesfaye, Ryan D. Gentzler, Claire Manuszak, Katrina Z. Kao, Ryan C. Brennick, Emily M. Thrash, Ana Lako, Anita Giobbie-Hurder, Arta M. Monjazeb
Supplementary Data and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef39a1bd1b4d365aae5a1aa7a6475ad
https://doi.org/10.1158/1078-0432.22484139.v1
https://doi.org/10.1158/1078-0432.22484139.v1
Autor:
Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T. Weber, Tejas R. Jammihal, Katrina Z. Kao, Edward T. Richardson, Tanya Keenan, Ofir Cohen, Michael P. Manos, Ryan C. Brennick, Patrick A. Ott, F. Stephen Hodi, Deborah A. Dillon, Victoria Attaya, Tess O'Meara, Nancy U. Lin, Eliezer M. Van Allen, Scott Rodig, Eric P. Winer, Elizabeth A. Mittendorf, Catherine J. Wu, Nikhil Wagle, Daniel G. Stover, Sachet A. Shukla, Sara M. Tolaney
Publikováno v:
JCO Precis Oncol
PURPOSE In metastatic triple-negative breast cancer (mTNBC), consistent biomarkers of immune checkpoint inhibitor (ICI) therapy benefit remain elusive. We evaluated the immune, genomic, and transcriptomic landscape of mTNBC in patients treated with I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fa82e75f5dc38813689b7ca3c1bdb4
https://europepmc.org/articles/PMC9848556/
https://europepmc.org/articles/PMC9848556/
Autor:
F. Stephen Hodi, Lisa Magarace, Jason L. Weirather, Brian J. Quattrochi, Nancy Bailey, Rizwan Haq, Michael Manos, Lynette M. Sholl, Patrick A. Ott, Elizabeth I. Buchbinder, Ryan C. Brennick, Anita Giobbie-Hurder, Peter Bowling, Benjamin Izar
Publikováno v:
Cancer Medicine, Vol 10, Iss 8, Pp 2627-2635 (2021)
Cancer Medicine
Cancer Medicine
Mucosal melanoma is a rare form of melanoma which arises from melanocytes in the mucosal membranes and can be effectively treated with immune checkpoint blockade (ICB). However, response rates in mucosal melanoma are lower than those observed for cut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4648f2b91bef2f506c9571a04f97a598
https://doaj.org/article/24cb2e96d164402e9d316cff9ef36d9a
https://doaj.org/article/24cb2e96d164402e9d316cff9ef36d9a
Autor:
Zachary Weber, Ryan C. Brennick, Catherine J. Wu, F. Steve Hodi, Michael Manos, Romualdo Barroso-Sousa, Katherine A Collier, Deborah A. Dillon, Patrick A. Ott, Katrina Z. Kao, Sara M. Tolaney, Nikhil Wagle, Tanya Keenan, Scott J. Rodig, Elizabeth A. Mittendorf, Daniel G. Stover, Eliezer E. Van Allen, Nan Lin, Ofir Cohen, Sachet A. Shukla, Eric P. Winer, Juliet Forman, Edward T. Richardson
Publikováno v:
Cancer Research. 81:PS4-25
Background: Genomic mechanisms associated with response to ICI in mTNBC are largely unknown. The aim of this work is to assess the genomic and immune profiles of mTNBC samples collected from patients (pts) treated with ICI. Methods: We identified 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6036fb06c73d0bf22a0ebc6f2afc4668
https://doi.org/10.1158/1538-7445.sabcs20-ps4-25
https://doi.org/10.1158/1538-7445.sabcs20-ps4-25
Autor:
Eliezer M. Van Allen, Rizwan Haq, Megha Shettigar, Cécile Gstalder, Elizabeth I. Buchbinder, Michael Manos, David A. Barbie, Ana Lako, Chenyu Lin, Scott J. Rodig, David Liu, Priya Pancholi, Gordon J. Freeman, Pei-Hsuan Chen, Vanesa Rojas-Rudilla, Scott L. Carter, Wayne O. Miles, Ryan C. Brennick, Alex Devine, Evisa Gjini, Diana Miao, Charles H. Yoon, Bart Lutterbach, F. Stephen Hodi
Publikováno v:
Cancer Discovery. 10:1296-1311
The molecular mechanisms leading to resistance to PD-1 blockade are largely unknown. Here, we characterize tumor biopsies from a patient with melanoma who displayed heterogeneous responses to anti–PD-1 therapy. We observe that a resistant tumor exh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3272f6705e3e856455c933eede384d0b
https://doi.org/10.1158/2159-8290.cd-19-1416
https://doi.org/10.1158/2159-8290.cd-19-1416
Autor:
Jonathan D Schoenfeld, Anita Giobbie-Hurder, Srinika Ranasinghe, Katrina Z Kao, Ana Lako, Junko Tsuji, Yang Liu, Ryan C Brennick, Ryan D Gentzler, Carrie Lee, Joleen Hubbard, Susanne M Arnold, James L Abbruzzese, Salma K Jabbour, Nataliya V Uboha, Kevin L Stephans, Jennifer M Johnson, Haeseong Park, Liza C Villaruz, Elad Sharon, Howard Streicher, Mansoor M Ahmed, Hayley Lyon, Carrie Cibuskis, Niall Lennon, Aashna Jhaveri, Lin Yang, Jennifer Altreuter, Lauren Gunasti, Jason L Weirather, Raymond H Mak, Mark M Awad, Scott J Rodig, Helen X Chen, Catherine J Wu, Arta M Monjazeb, F Stephen Hodi
Publikováno v:
Lancet Oncol
The Lancet. Oncology, vol 23, iss 2
The Lancet. Oncology, vol 23, iss 2
BackgroundPatients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that radiotherapy could enhance antitumour immunity. Therefore, we investigated the potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb413a3e2f50d891f3a6467eb8df660
https://pubmed.ncbi.nlm.nih.gov/35358457
https://pubmed.ncbi.nlm.nih.gov/35358457
Autor:
Anita Giobbie-Hurder, Ryan C. Brennick, F. Stephen Hodi, Jonathan Stevens, Meghna Gupta, Tianqi Chen, Indira Guleria, Jingjing Li, Xinqi Wu, Michael Manos, Jun Zhou
Publikováno v:
Cancer Immunol Immunother
Expression of inhibitors of apoptosis protein (IAP) family members is associated with poor prognosis in cancer patients. Immunity to ML-IAP (livin) and survivin have been well studied in patients with a variety of tumors. XIAP, the most potent inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0abff5bdf884641eeaaa2ee33dbf7ef
https://doi.org/10.1007/s00262-019-02370-4
https://doi.org/10.1007/s00262-019-02370-4
Autor:
Jonathan D. Schoenfeld, Anita Giobbie-Hurder, Srinika Ranasinghe, Katrina Z. Kao, Ana Lako, Junko Tsuji, Yang Liu, Ryan C. Brennick, Ryan Gentzler, Carrie Lee, Joleen Hubbard, James L. Abbruzzese, Salma K. Jabbour, Nataliya Uboha, Kevin Stephans, Jennifer M. Johnson, Haesong Park, Lisa C. Villaruz, Elad Sharon, Howard Streicher, Mansoor Ahmed, Hayley Lyon, Carrie Cibuskis, Niall Lennon, Aashna Jhaveri, Lin Yang, Jennifer Altreuter, Lauren Gunasti, Jason L. Weirather, Raymond H. Mak, Mark M. Awad, Scott J. Rodig, Helen X. Chen, Catherine J. Wu, Arta M. Monjazeb, F. Stephen Hodi
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf93d065b05fbe53a3e25133c1545807
https://doi.org/10.2139/ssrn.3922682
https://doi.org/10.2139/ssrn.3922682