Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin

Autor: Jing Zhang, Marina A. Bellani, Jing Huang, Ryan C. James, Durga Pokharel, Julia Gichimu, Himabindu Gali, Grant Stewart, Michael M. Seidman

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering a

Externí odkaz: https://doaj.org/article/bbbb56aa032e43b0951f58fbf4559590

Abstract 9423: Virtual Reality (VR) Guided Telerobotic Cardiac Catheter Ablation is Feasible Over Low Bandwidth Network Connection

Autor: Stephen P Seslar, Ryan C James, Blake Hannaford, Basil Saour, Wayne Monsky

Publikováno v: Circulation. 144

Introduction: Telerobotic operation in which a remote surgeon performs an operation over distance has long held the promise of providing a more equitable distribution of healthcare in rural and underserved regions of the world. One of the technologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4637ea1f8099fc8e03022d824160712e
https://doi.org/10.1161/circ.144.suppl_1.9423

Semantics-Based Composition of Integrated Cardiomyocyte Models Motivated by Real-World Use Cases.

Autor: Maxwell L Neal, Brian E Carlson, Christopher T Thompson, Ryan C James, Karam G Kim, Kenneth Tran, Edmund J Crampin, Daniel L Cook, John H Gennari

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145621 (2015)

Semantics-based model composition is an approach for generating complex biosimulation models from existing components that relies on capturing the biological meaning of model elements in a machine-readable fashion. This approach allows the user to wo

Externí odkaz: https://doaj.org/article/6c6a2442c32b46c0bac7716bbd4a5dbd

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Autor: Gavin S. McNee, Jing Zhang, Durga Pokharel, Grant S. Stewart, Ryan C James, Yongqing Zhang, John J. Reynolds, Michael M. Seidman, Marina A. Bellani, Andrew P. Jackson

Publikováno v: Zhang, J, Bellani, M A, James, R C, Pokharel, D, Zhang, Y, Reynolds, J J, McNee, G S, Jackson, A P, Stewart, G S & Seidman, M M 2020, ' DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain ', Nature Communications, vol. 11, no. 1, pp. 3951 . https://doi.org/10.1038/s41467-020-17449-1
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications

Duplication of mammalian genomes requires replisomes to overcome numerous impediments during passage through open (eu) and condensed (hetero) chromatin. Typically, studies of replication stress characterize mixed populations of challenged and unchall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c851bb2ae9cc2384921e694cae79affc
https://doi.org/10.1038/s41467-020-17449-1

Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2

Autor: Ryan C. James, Amom Ruhikanta Meetei, Michael M. Seidman, Zhijiang Yan, Jing Zhang, Durga Pokharel, Chen Ling, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Junjie Chen, Lei Li, Weidong Wang, Dongyi Xu, Jing Huang

Publikováno v: Cell Reports, Vol 27, Iss 6, Pp 1794-1808.e5 (2019)

Summary: Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b47bc5bd1347109164f5d937f2610
https://doi.org/10.1016/j.celrep.2019.04.032