Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Ryan A Mehl"'
Autor:
Duk-Su Koh, Anastasiia Stratiievska, Subhashis Jana, Shauna C Otto, Teresa M Swanson, Anthony Nhim, Sara Carlson, Marium Raza, Ligia Araujo Naves, Eric N Senning, Ryan A Mehl, Sharona E Gordon
Publikováno v:
eLife, Vol 12 (2024)
Ligands such as insulin, epidermal growth factor, platelet-derived growth factor, and nerve growth factor (NGF) initiate signals at the cell membrane by binding to receptor tyrosine kinases (RTKs). Along with G-protein-coupled receptors, RTKs are the
Externí odkaz:
https://doaj.org/article/4da9d7ab97974baea2685bfc3abbcc20
Autor:
William N Zagotta, Brandon S Sim, Anthony K Nhim, Marium M Raza, Eric GB Evans, Yarra Venkatesh, Chloe M Jones, Ryan A Mehl, E James Petersson, Sharona E Gordon
Publikováno v:
eLife, Vol 10 (2021)
With the recent explosion in high-resolution protein structures, one of the next frontiers in biology is elucidating the mechanisms by which conformational rearrangements in proteins are regulated to meet the needs of cells under changing conditions.
Externí odkaz:
https://doaj.org/article/93b61d38288c44e393a7774bb956124a
Autor:
Debashree Chatterjee, Richard B Cooley, Chelsea D Boyd, Ryan A Mehl, George A O'Toole, Holger Sondermann
Publikováno v:
eLife, Vol 3 (2014)
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm formation, a prevalent adaptation strategy in response to changing environments. In Pseudomonas fluorescens, this process is regulated by the Lap system and the s
Externí odkaz:
https://doaj.org/article/1a908a9476a04e1f807be5dd4f8753cb
Autor:
Grace D. Galles, Daniel T. Infield, Colin J. Clark, Marcus L. Hemshorn, Shivani Manikandan, Frederico Fazan, Ali Rasouli, Emad Tajkhorshid, Jason D. Galpin, Richard B. Cooley, Ryan A. Mehl, Christopher A. Ahern
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Aromatic amino acids in proteins support ligand binding and protein stability. To parse the physiocochemical roles of aromatic interactions, here Galles, Infield and co-authors identify pyrrolysine-based aminoacyl-tRNA synthetases that enable the enc
Externí odkaz:
https://doaj.org/article/bf16f9a0529447d48911d7bab7bf37ef
Autor:
Longteng Tang, Riley M. Bednar, Nikita D. Rozanov, Marcus L. Hemshorn, Ryan A. Mehl, Chong Fang
Publikováno v:
Natural Sciences, Vol 2, Iss 4, Pp n/a-n/a (2022)
Abstract The development of bioorthogonal fluorogenic probes constitutes a vital force to advance life sciences. Tetrazine‐encoded green fluorescent proteins (GFPs) show high bioorthogonal reaction rate and genetic encodability but suffer from low
Externí odkaz:
https://doaj.org/article/5bb1da02a4f843db8c78ec7064008817
Autor:
Megan Jandy, Asra Noor, Pascal Nelson, Cassandra N. Dennys, Isabella M. Karabinas, Jeanine C. Pestoni, Gautam D. Singh, Lam Luc, Rachel Devyldere, Nathalie Perdomo, Catherine E. Mitchell, Levi Adams, Marisa A. Fuse, Francine A. Mendoza, Carrie L. Marean-Reardon, Ryan A. Mehl, Alvaro G. Estevez, Maria Clara Franco
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102247- (2022)
The diffusion-limited reaction of nitric oxide (NO) and superoxide (O2−) produces peroxynitrite (ONOO−), a biological oxidant that has been implicated in a number of pathological conditions, including neurodegenerative disorders. We previously re
Externí odkaz:
https://doaj.org/article/cb410cd2eb514e079fc19b53c379212a
Autor:
Elise M. Van Fossen, Sonia Grutzius, Carl E. Ruby, Dan V. Mourich, Chris Cebra, Shay Bracha, P. Andrew Karplus, Richard B. Cooley, Ryan A. Mehl
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species are innocuous by-products of pathology and which are causative agents. To achieve this goal, techn
Externí odkaz:
https://doaj.org/article/e7ee875dac2c4ee68361d8663535c867
Autor:
Phillip Zhu, Stanislau Stanisheuski, Rachel Franklin, Amber Vogel, Cat Hoang Vesely, Patrick Reardon, Nikolai N. Sluchanko, Joseph S. Beckman, P. Andrew Karplus, Ryan A. Mehl, Richard B. Cooley
Publikováno v:
ACS Central Science. 9:816-835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::735c8f2c6744e63b8ade649081062c56
https://doi.org/10.1021/acscentsci.3c00191
https://doi.org/10.1021/acscentsci.3c00191
Publikováno v:
Cell Chemical Biology. 30:343-361
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c1f9ab05a610466d667c07b372198b9
https://doi.org/10.1016/j.chembiol.2023.03.004
https://doi.org/10.1016/j.chembiol.2023.03.004
Autor:
Longteng Tang, Riley M. Bednar, Nikita D. Rozanov, Marcus L. Hemshorn, Ryan A. Mehl, Chong Fang
Publikováno v:
Natural sciences (Weinheim, Germany). 2(4)
The development of bioorthogonal fluorogenic probes constitutes a vital force to advance life sciences. Tetrazine-encoded green fluorescent proteins (GFPs) show high bioorthogonal reaction rate and genetic encodability, but suffer from low fluorogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8d611df52c55c703c5283eed31898e
https://pubmed.ncbi.nlm.nih.gov/36440454
https://pubmed.ncbi.nlm.nih.gov/36440454