Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ryan A Hlady"'
Autor:
Staci L Haney, G Michael Upchurch, Jana Opavska, David Klinkebiel, Ryan A Hlady, Sohini Roy, Samikshan Dutta, Kaustubh Datta, Rene Opavsky
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006334 (2016)
DNA methyltransferase 3A (DNMT3A) is an enzyme involved in DNA methylation that is frequently mutated in human hematologic malignancies. We have previously shown that inactivation of Dnmt3a in hematopoietic cells results in chronic lymphocytic leukem
Externí odkaz:
https://doaj.org/article/defdbaef252c4ac88a303c4a88a5c499
Autor:
Tianchu Wang, Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Xia Zhao, Sungho Kim, Liguo Wang, Jeong‐Heon Lee, Huijun Luo, Erik P. Castle, Douglas F. Lake, Thai H. Ho, Keith D. Robertson
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 44-61 (2024)
Histone‐lysine N‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is often mutated in clear cell renal cell carcinoma (ccRCC). SETD2 mutation and/or loss of H
Externí odkaz:
https://doaj.org/article/94fc00dd4ad84cafa77273b4de5bc7d6
Autor:
Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho, Keith D. Robertson
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unus
Externí odkaz:
https://doaj.org/article/584e5c915d604bcbbb2b14be31291f9d
Autor:
David L. Marks, Rachel L. Olson, Raul Urrutia, Daniel D. Billadeau, Nilotpal Roy, George A. Calin, Muller Fabbri, Marina Koutsioumpa, Dimitrios Iliopoulos, Tamas Ordog, Robert Huebert, Olga Sarmento, Adebowale O. Bamidele, William Faubion, Gwen L. Lomberk, Jens Siveke, Nita Ahuja, Juan Iovanna, Ryan A. Hlady, Keith Robertson, John Kisiel, Christopher L. Pin, Martin E. Fernandez-Zapico
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 449-457 (2018)
International experts gathered at the Mayo Clinic (Rochester MN, USA) on February 27th-28th, 2017 for a meeting entitled ‘Basic and Translational Facets of the Epigenetics of GI Diseases’. This workshop summarized recent advances on the role of e
Externí odkaz:
https://doaj.org/article/23e86de7b3ef46bbaca872d31226b0f5
Publikováno v:
Epigenetics, Vol 12, Iss 3, Pp 215-225 (2017)
While intratumor heterogeneity contributes to disease progression, metastasis, and resistance to chemotherapy, it also provides a route to understanding the evolution and drivers of disease. Defects in epigenetic landscapes are intimately linked to p
Externí odkaz:
https://doaj.org/article/76eea5d98737403d8d857a4ecc0cab91
Autor:
Dan Zhou, Ryan A. Hlady, Marissa J. Schafer, Thomas A. White, Chen Liu, Jeong-Hyeon Choi, Jordan D. Miller, Lewis R. Roberts, Nathan K. LeBrasseur, Keith D. Robertson
Publikováno v:
Epigenetics, Vol 12, Iss 1, Pp 55-69 (2017)
High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health benefits in populations with or without these chronic conditions. Diet and exercise regulate
Externí odkaz:
https://doaj.org/article/db721df4375e4b2baa4d9177f1e695a9
Autor:
Ryan A. Hlady, Keith D. Robertson
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b26033dd2c51b1a849d70c56c4e8b7d
https://doi.org/10.1097/hep.0000000000000414
https://doi.org/10.1097/hep.0000000000000414
Autor:
Xia Zhao, Qunfeng Wu, Aesis Luna, Chen Liu, Ryan A. Hlady, Jeong Heon Lee, Nikolaos Pyrsopoulos, Kien Pham, Louis El Khoury, Keith D. Robertson
Publikováno v:
Hepatology
Background & aims Chronic hepatitis C viral (HCV) infection is a leading etiologic driver of cirrhosis and ultimately hepatocellular carcinoma (HCC). Of the approximately 71 million individuals chronically infected with HCV, 10-20% are expected to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4e57da99541b0e1a6531c70f29f7ef
https://pubmed.ncbi.nlm.nih.gov/34387871
https://pubmed.ncbi.nlm.nih.gov/34387871
Publikováno v:
Cancer Medicine, Vol 8, Iss 12, Pp 5760-5768 (2019)
Cancer Medicine
Cancer Medicine
There are currently no effective treatments for advanced‐stage papillary renal cell carcinoma (PRCC). The goal of this study is to define potential DNA methylation‐based markers and treatment targets for advanced‐stage type 2 PRCC. Progressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184e2db93b989a5b41bac1ad96145354
https://doaj.org/article/b15879f620204bc092cfdc8e3b685316
https://doaj.org/article/b15879f620204bc092cfdc8e3b685316
Autor:
Qunfeng Wu, Joyce J. Thompson, Jeong Heon Lee, Chen Liu, Ryan A. Hlady, Dan Zhou, Aishwarya Sathyanarayan, Kien Pham, Keith D. Robertson
Publikováno v:
Hepatology. 69:639-652
Disruption of epigenetic mechanisms has been intimately linked to the etiology of human cancer. Understanding how these epigenetic mechanisms (including DNA methylation (5mC), hydroxymethylation (5hmC), and histone post-translational modifications) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bbd01a029c2dc63ad4a9f80d11b74c
https://doi.org/10.1002/hep.30211
https://doi.org/10.1002/hep.30211