Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ryan A Hlady"'
Autor:
Tianchu Wang, Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Xia Zhao, Sungho Kim, Liguo Wang, Jeong‐Heon Lee, Huijun Luo, Erik P. Castle, Douglas F. Lake, Thai H. Ho, Keith D. Robertson
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 44-61 (2024)
Histone‐lysine N‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on histone H3 (H3K36me3), is often mutated in clear cell renal cell carcinoma (ccRCC). SETD2 mutation and/or loss of H
Externí odkaz:
https://doaj.org/article/94fc00dd4ad84cafa77273b4de5bc7d6
Autor:
Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho, Keith D. Robertson
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unus
Externí odkaz:
https://doaj.org/article/584e5c915d604bcbbb2b14be31291f9d
Publikováno v:
Cancer Medicine, Vol 8, Iss 12, Pp 5760-5768 (2019)
Abstract There are currently no effective treatments for advanced‐stage papillary renal cell carcinoma (PRCC). The goal of this study is to define potential DNA methylation‐based markers and treatment targets for advanced‐stage type 2 PRCC. Pro
Externí odkaz:
https://doaj.org/article/b15879f620204bc092cfdc8e3b685316
Autor:
David L. Marks, Rachel L. Olson, Raul Urrutia, Daniel D. Billadeau, Nilotpal Roy, George A. Calin, Muller Fabbri, Marina Koutsioumpa, Dimitrios Iliopoulos, Tamas Ordog, Robert Huebert, Olga Sarmento, Adebowale O. Bamidele, William Faubion, Gwen L. Lomberk, Jens Siveke, Nita Ahuja, Juan Iovanna, Ryan A. Hlady, Keith Robertson, John Kisiel, Christopher L. Pin, Martin E. Fernandez-Zapico
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 449-457 (2018)
International experts gathered at the Mayo Clinic (Rochester MN, USA) on February 27th-28th, 2017 for a meeting entitled ‘Basic and Translational Facets of the Epigenetics of GI Diseases’. This workshop summarized recent advances on the role of e
Externí odkaz:
https://doaj.org/article/23e86de7b3ef46bbaca872d31226b0f5
Autor:
Dan Zhou, Bonnie M. Alver, Shuang Li, Ryan A. Hlady, Joyce J. Thompson, Mark A. Schroeder, Jeong-Heon Lee, Jingxin Qiu, Philip H. Schwartz, Jann N. Sarkaria, Keith D. Robertson
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-25 (2018)
Abstract Background Glioma stem cells (GSCs) are a subpopulation of stem-like cells that contribute to glioblastoma (GBM) aggressiveness, recurrence, and resistance to radiation and chemotherapy. Therapeutically targeting the GSC population may impro
Externí odkaz:
https://doaj.org/article/06bbb5a54d654ef9a3902660f5f0ff55
Publikováno v:
Epigenetics, Vol 12, Iss 3, Pp 215-225 (2017)
While intratumor heterogeneity contributes to disease progression, metastasis, and resistance to chemotherapy, it also provides a route to understanding the evolution and drivers of disease. Defects in epigenetic landscapes are intimately linked to p
Externí odkaz:
https://doaj.org/article/76eea5d98737403d8d857a4ecc0cab91
Autor:
Dan Zhou, Ryan A. Hlady, Marissa J. Schafer, Thomas A. White, Chen Liu, Jeong-Hyeon Choi, Jordan D. Miller, Lewis R. Roberts, Nathan K. LeBrasseur, Keith D. Robertson
Publikováno v:
Epigenetics, Vol 12, Iss 1, Pp 55-69 (2017)
High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health benefits in populations with or without these chronic conditions. Diet and exercise regulate
Externí odkaz:
https://doaj.org/article/db721df4375e4b2baa4d9177f1e695a9
Autor:
Ryan A. Hlady, Keith D. Robertson
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b26033dd2c51b1a849d70c56c4e8b7d
https://doi.org/10.1097/hep.0000000000000414
https://doi.org/10.1097/hep.0000000000000414
Autor:
Staci L. Haney, G. Michael Upchurch, Jana Opavska, David Klinkebiel, Ryan A. Hlady, Abhinav Suresh, Samuel J. Pirruccello, Vipul Shukla, Runqing Lu, Stefan Costinean, Angie Rizzino, Adam R. Karpf, Shantaram Joshi, Patrick Swanson, Rene Opavsky
Publikováno v:
Cell Reports, Vol 15, Iss 6, Pp 1190-1201 (2016)
DNA methyltransferase 3a (DNMT3A) catalyzes the formation of 5-methyl-cytosine in mammalian genomic DNA, and it is frequently mutated in human hematologic malignancies. Bi-allelic loss of Dnmt3a in mice results in leukemia and lymphoma, including chr
Externí odkaz:
https://doaj.org/article/81cec469daba481b8789478486a1ac8e
Autor:
Rochelle L. Tiedemann, Emily L. Putiri, Jeong-Heon Lee, Ryan A. Hlady, Katsunobu Kashiwagi, Tamas Ordog, Zhiguo Zhang, Chen Liu, Jeong-Hyeon Choi, Keith D. Robertson
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1554-1566 (2014)
Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs
Externí odkaz:
https://doaj.org/article/c2351c6c5cd8442987af385f16c595c6