Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ryan Thummel"'
Autor:
Ashley C. Kramer, Justin Carthage, Yasmeen Berry, Katherine Gurdziel, Tiffany A. Cook, Ryan Thummel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: Adult zebrafish are capable of photoreceptor (PR) regeneration following acute phototoxic lesion (AL). We developed a chronic low light (CLL) exposure model that more accurately reflects chronic PR degeneration observed in many human reti
Externí odkaz:
https://doaj.org/article/3b5f7e1186d642b4a39051c84834166a
Autor:
Shreya Banerjee, Lillian E. Ranspach, Xixia Luo, Lauren T. Cianciolo, Joseph Fogerty, Brian D. Perkins, Ryan Thummel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Genetic Leukoencephalopathies (gLEs) are heritable white matter disorders that cause progressive neurological abnormalities. A founder mutation in the human endolysosomal trafficking protein VPS11 has been identified in Ashkenazi Jewish pati
Externí odkaz:
https://doaj.org/article/6f64d3a254584f778dcb03c9f3b43868
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Following photoreceptors ablation by intense light exposure, adult zebrafish are capable of complete regeneration due to the ability of their Müller glia (MG) to re-enter the cell cycle, creating progenitors that differentiate into new photoreceptor
Externí odkaz:
https://doaj.org/article/b9a247e35ef0462db31628c0525f1298
Publikováno v:
ASN Neuro, Vol 13 (2021)
A founder mutation in human VPS11 ( Vacuolar Protein Sorting 11 ) was recently linked to a genetic leukoencephalopathy in Ashkenazi Jews that presents with the classical features of white matter disorders of the central nervous system (CNS). The neur
Externí odkaz:
https://doaj.org/article/56cfe71004104fff966c326e4506b752
Autor:
Nicholas B Ang, Alfonso Saera-Vila, Caroline Walsh, Peter F Hitchcock, Alon Kahana, Ryan Thummel, Mikiko Nagashima
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232308 (2020)
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors. Proliferation among the cells that will functionally re
Externí odkaz:
https://doaj.org/article/ca5cb3c2653942468b4b3667810fd925
Publikováno v:
PeerJ, Vol 6, p e5646 (2018)
Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult
Externí odkaz:
https://doaj.org/article/579a1ae14dac4c148e00227edacc1bcc
Autor:
James G Granneman, Vickie A Kimler, Huamei Zhang, Xiangqun Ye, Xixia Luo, John H Postlethwait, Ryan Thummel
Publikováno v:
eLife, Vol 6 (2017)
Perilipin (PLIN) proteins constitute an ancient family important in lipid droplet (LD) formation and triglyceride metabolism. We identified an additional PLIN clade (plin6) that is unique to teleosts and can be traced to the two whole genome duplicat
Externí odkaz:
https://doaj.org/article/95247d18b4bc458b88bef0b57986361c
Publikováno v:
Pathogens, Vol 8, Iss 4, p 207 (2019)
Gram-positive bacteria remain the leading cause of endophthalmitis, a blinding infectious disease of the eye. Murine models have been widely used for understanding the pathogenesis of bacterial endophthalmitis. In this study, we sought to develop an
Externí odkaz:
https://doaj.org/article/3d8deb58c3c54aab8d13a72ee1393242
Autor:
Jeremiah N. Shields, Eric C. Hales, Lillian E. Ranspach, Xixia Luo, Steven Orr, Donna Runft, Alan Dombkowski, Melody N. Neely, Larry H. Matherly, Jeffrey Taub, Tracie R. Baker, Ryan Thummel
Publikováno v:
Toxics, Vol 7, Iss 4, p 50 (2019)
Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to pesticide exposure warrants f
Externí odkaz:
https://doaj.org/article/0bffc0801d654e71a429aecd7ebb3528
Autor:
Jinglan Zhang, Véronik Lachance, Adam Schaffner, Xianting Li, Anastasia Fedick, Lauren E Kaye, Jun Liao, Jill Rosenfeld, Naomi Yachelevich, Mary-Lynn Chu, Wendy G Mitchell, Richard G Boles, Ellen Moran, Mari Tokita, Elizabeth Gorman, Kaytee Bagley, Wei Zhang, Fan Xia, Magalie Leduc, Yaping Yang, Christine Eng, Lee-Jun Wong, Raphael Schiffmann, George A Diaz, Ruth Kornreich, Ryan Thummel, Melissa Wasserstein, Zhenyu Yue, Lisa Edelmann
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005848 (2016)
Genetic leukoencephalopathies (gLEs) are a group of heterogeneous disorders with white matter abnormalities affecting the central nervous system (CNS). The causative mutation in ~50% of gLEs is unknown. Using whole exome sequencing (WES), we identifi
Externí odkaz:
https://doaj.org/article/58d4941c9bb24969bfbc11da1f857ebc