Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ryan Stansfield"'
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and secretion of the pro-inflammatory cytokines, IL-1β and IL-18. Persistent activation
Externí odkaz:
https://doaj.org/article/a9366cea20b64379ae3b798f5d428a2d
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71601d03ca0a42d8941718d51407d3e9
Autor:
Christopher McBride, Lynnie Trzoss, Davide Povero, Milos Lazic, Geza Ambrus-Aikelin, Angelina Santini, Rama Pranadinata, Gretchen Bain, Ryan Stansfield, Jeffrey A. Stafford, James Veal, Ryan Takahashi, Justin Ly, Shu Chen, Liling Liu, Marika Nespi, Robert Blake, Arna Katewa, Tracy Kleinheinz, Swathi Sujatha-Bhaskar, Nandhini Ramamoorthi, Jessica Sims, Brent McKenzie, Mark Chen, Mark Ultsch, Matthew Johnson, Jeremy Murray, Claudio Ciferri, Steven T. Staben, Michael J. Townsend, Craig E. Stivala
Publikováno v:
Journal of Medicinal Chemistry. 65:14721-14739
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ab527cf94dae143f3c4497446ed964
https://doi.org/10.1021/acs.jmedchem.2c01250
https://doi.org/10.1021/acs.jmedchem.2c01250
Autor:
David J. Hosfield, Jiangchun Xu, Young K. Chen, Matt M. Kreilein, James Marvin Veal, Chon Lai, Christophe Severin, Toufike Kanouni, Stephen W. Kaldor, Lee N. Lawton, Robert Cho, Joselyn R. Del Rosario, Ryan Stansfield, Jeffrey A. Stafford, Natalie Y.-Y. Yuen, Shawn O’Connell, Paula Alessandra Tavares-Greco, Zhe Nie, Lihong Shi
Publikováno v:
Journal of Medicinal Chemistry. 63:14522-14529
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are hallmarks of a number of human dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ec0fbdb2c348ac2a377e0b118afeee
https://doi.org/10.1021/acs.jmedchem.0c00978
https://doi.org/10.1021/acs.jmedchem.0c00978
Autor:
Lihong Shi, Jiangchun Xu, A. Boloor, Stephen W. Kaldor, David J. Hosfield, J.M. Betancort, Jennifer Matuszkiewicz, James M. Veal, M.J. Bennett, Ryan Stansfield, Shawn M. O'Connell, Jeffrey A. Stafford, J.R. Del Rosario, Y. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1811-1816
The bromodomain and extra-terminal (BET) family of epigenetic proteins has attracted considerable attention in drug discovery given its involvement in regulating gene transcription. Screening a focused small molecule library based on the bromodomain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31407f48e8a977590add29852567d58
https://doi.org/10.1016/j.bmcl.2018.04.016
https://doi.org/10.1016/j.bmcl.2018.04.016
Autor:
Joselyn R. Del Rosario, James M. Veal, Young K. Chen, Lihong Shi, Zhe Nie, Ryan Stansfield, Christophe Severin, Chon Lai, Robert Cho, Toufike Kanouni, Jiangchun Xu, Jeffrey A. Stafford
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
The histone demethylase LSD1 is a key enzyme in the epigenetic regulation of gene transcription. Here we present our efforts to discover small molecule reversible inhibitors of LSD1 as an attractive approach to treat hematologic malignancies and cert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7246198898384f04a1ff5e6e36acb6
https://pubmed.ncbi.nlm.nih.gov/30409536
https://pubmed.ncbi.nlm.nih.gov/30409536
Autor:
Andrew McGeehan, Joselyn R. Del Rosario, Young K. Chen, Lihong Shi, James M. Veal, Michael S. Weiss, David J. Hosfield, Alessandro Cuomo, Neethan A. Lobo, Jennifer Matuszkiewicz, Shih Chu Kao, Jeffrey A. Stafford, Tiziana Bonaldi, Michael Brennan Wallace, Natalie Y. Yuen, Ryan Stansfield, Shawn M. O'Connell, Chon Lai, Toufike Kanouni
Publikováno v:
ACS medicinal chemistry letters. 8(8)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fac222f0833b41a42e89ee96531a18
https://pubmed.ncbi.nlm.nih.gov/28835804
https://pubmed.ncbi.nlm.nih.gov/28835804
Autor:
Trzoss Lynnie Lin, Christopher McBride, Casey D. Johnson, Ryan Stansfield, Ariel E. Feldstein, G. Ambrus, Jeffery Alan Stafford, J. Veal, A. Santini, Davide Povero, Milos Lazic
Publikováno v:
Journal of Hepatology. 68:S347-S348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8eae78c92cda913c1fbddfb712fe3c7
https://doi.org/10.1016/s0168-8278(18)30917-6
https://doi.org/10.1016/s0168-8278(18)30917-6
Autor:
Jeffrey P. Whitten, Ryan Stansfield, Chris Proffitt, Adam Siddiqui-Jain, Johnny Y. Nagasawa, Josh Bliesath, Pauline Kerdoncuff, Kenna Anderes, David M. Ryckman, Nanni Huser, May Omori, Levan Darjania, William G. Rice, Mustapha Haddach, Denis Drygin, Jerome Michaux, Michael K. Schwaebe, Fabrice Pierre, Sean O'Brien
Publikováno v:
ACS Medicinal Chemistry Letters. 3:602-606
Accelerated proliferation of solid tumor and hematologic cancer cells is linked to accelerated transcription of rDNA by the RNA polymerase I (Pol I) enzyme to produce elevated levels of rRNA (rRNA). Indeed, upregulation of Pol I, frequently caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472fd5810e796ea42951640dfe4fa1ba
https://doi.org/10.1021/ml300110s
https://doi.org/10.1021/ml300110s
Autor:
Chris Proffitt, Johnny Y. Nagasawa, Levan Darjania, Eric Stefan, Ryan Stansfield, Sean O'Brien, Nicole Streiner, Jeffrey P. Whitten, Joshua R. Bliesath, Peter C. Chua, Caroline B. Ho, Pauline Bourbon, William G. Rice, Fabrice Pierre, Adam Siddiqui-Jain, Ta Kung Chen, Kenna Anderes, Anne Vialettes, Mustapha Haddach, David M. Ryckman, Michael K. Schwaebe, Denis Drygin, Jerome Michaux, May Omori
Publikováno v:
Molecular and Cellular Biochemistry. 356:37-43
In this article we describe the preclinical characterization of 5-(3-chlorophenylamino) benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first orally available small molecule inhibitor of protein CK2 in clinical trials for cancer. CX-4945
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8047df7df0af652af52401571f4b18f3
https://doi.org/10.1007/s11010-011-0956-5
https://doi.org/10.1007/s11010-011-0956-5