Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Ryan P. Wurz"'
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Akademický článek
Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation
Autor: Ryan P. Wurz, Huan Rui, Ken Dellamaggiore, Sudipa Ghimire-Rijal, Kaylee Choi, Kate Smither, Albert Amegadzie, Ning Chen, Xiaofen Li, Abhisek Banerjee, Qing Chen, Dane Mohl, Amit Vaish
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Targeted protein degradation via “hijacking” of the ubiquitin-proteasome system using proteolysis targeting chimeras (PROTACs) has evolved into a novel therapeutic modality. The design of PROTACs is challenging; multiple steps involved i
Externí odkaz: https://doaj.org/article/de7e722d28104330ab18533bf9830472
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4
Formal Synthesis of Belactosin A and Hormaomycin via a Diastereoselective Intramolecular Cyclopropanation of an α-Nitro Diazoester
Autor: Guillaume Larouche, André B. Charette, Sébastien F Vanier, Ryan P. Wurz
Publikováno v: Organic Letters. 12:672-675
An efficient and convenient methodology for the synthesis of the 3-(trans-2-aminocyclopropyl) alanine and 3-(trans-2-nitrocyclopropyl) alanine moieties found in the core of belactosin A and hormaomycin, respectively, is reported. By using an enantioe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef15e25dc86dd3b34478a0f82c2d0a1
https://doi.org/10.1021/ol9026528
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5
Synthesis and Resolution of Planar-Chiral Derivatives of 4-(Dimethylamino)pyridine
Autor: J. Craig Ruble, Ryan P. Wurz, Elaine C. Lee, Gregory C. Fu
Publikováno v: Advanced Synthesis & Catalysis. 349:2345-2352
A safer and more efficient method for the synthesis of planar-chiral 4-(dimethylamino)pyridine (DMAP) derivatives has been developed. Racemic mixtures of the complexes can be resolved via classical resolution with commercially available tartaric acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bf5412bf8bd40db376d4665960159d4
https://doi.org/10.1002/adsc.200700219
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6
Doubly Activated Cyclopropanes as Synthetic Precursors for the Preparation of 4-Nitro- and 4-Cyano-dihydropyrroles and Pyrroles
Autor: Ryan P. Wurz, André B. Charette
Publikováno v: Organic Letters. 7:2313-2316
[reaction: see text] 1-Nitro- and 1-cyano-cyclopropyl ketones have been prepared in an expedient manner from cyclopropanation reactions of alkenes by diazo compounds or in situ-generated phenyliodonium ylides catalyzed by Rh(II) carboxylates. The dou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4088da04ebbf7fc09200f05265ba8265
https://doi.org/10.1021/ol050442l
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7
An Expedient and Practical Method for the Synthesis of a Diverse Series of Cyclopropane α-Amino Acids and Amines
Autor: André B. Charette, Ryan P. Wurz
Publikováno v: The Journal of Organic Chemistry. 69:1262-1269
A practical synthesis for the preparation of a diverse series of cyclopropane alpha-amino acids is described. Nitrocyclopropane carboxylates can be readily prepared through treatment of alpha-nitroesters and iodobenzene diacetate or alpha-nitro-alpha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5df6190d783885ef92008e0a92c26b
https://doi.org/10.1021/jo035596y
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8
Trifluoromethanesulfonyl azide: an efficient reagent for the preparation of α-cyano-α-diazo carbonyls and an α-sulfonyl-α-diazo carbonyl
Autor: Wei Lin, André B. Charette, Ryan P. Wurz
Publikováno v: Tetrahedron Letters. 44:8845-8848
The reaction scope of trifluoromethanesulfonyl azide in diazo transfer reactions was extended to include the preparation of α-cyano-α-diazo-carbonyls, phenyl sulfonyl diazoacetophenone and diethyl diazomalonate in high yields. The effect of the bas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726c7c30b137d3f066e87954a36e82f9
https://doi.org/10.1016/j.tetlet.2003.09.197
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9
Progress towards asymmetric intermolecular and intramolecular cyclopropanations using α-nitro-α-diazo carbonyl substrates
Autor: André B. Charette, Ryan P. Wurz
Publikováno v: Journal of Molecular Catalysis A: Chemical. 196:83-91
A variety of Rh(II) catalysts were screened for enantioselectivity in the cyclopropanation of styrene with α-nitro-α-diazo carbonyl compounds and found to give modest to high yields in a wide range of solvents but modest enantioselectivities (up to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54e59658018e50c074bcdd18e376d139
https://doi.org/10.1016/s1381-1169(02)00636-2
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10
Synthesis of -Nitro--diazocarbonyl Derivatives and Their Applications in the Cyclopropanation of Alkenes and in OH Insertion Reactions
Autor: Ryan P. Wurz, André B. Charette, Thierry Ollevier
Publikováno v: Helvetica Chimica Acta. 85:4468-4484
A facile and highly efficient method for the preparation of α-nitro-α-diazocarbonyl derivatives by a diazo-transfer reaction involving (trifluoromethyl)sulfonyl azide has been developed. These substrates undergo a rhodium-catalyzed cyclopropanation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ba62f0450d3a11496736b4c533efc0c
https://doi.org/10.1002/hlca.200290023
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