Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ryan MacArthur"'
Autor:
Hao Yu, Patricia Dranchak, Zhiru Li, Ryan MacArthur, Matthew S. Munson, Nurjahan Mehzabeen, Nathan J. Baird, Kevin P. Battalie, David Ross, Scott Lovell, Clotilde K. S. Carlow, Hiroaki Suga, James Inglese
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglyce
Externí odkaz:
https://doaj.org/article/39345025d3334fe096b7ce4373349fee
Autor:
Thomas W Miller, Joshua D Amason, Elsa D Garcin, Laurence Lamy, Patricia K Dranchak, Ryan Macarthur, John Braisted, Jeffrey S Rubin, Teresa L Burgess, Catherine L Farrell, David D Roberts, James Inglese
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the
Externí odkaz:
https://doaj.org/article/72f1809b5d2d4362be19df63504e4ef9
Autor:
Patricia Dranchak, Ryan MacArthur, Rajarshi Guha, William J Zuercher, David H Drewry, Douglas S Auld, James Inglese
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57888 (2013)
A library of 367 protein kinase inhibitors, the GSK Published Kinase Inhibitor Set (PKIS), which has been annotated for protein kinase family activity and is available for public screening efforts, was assayed against the commonly used luciferase rep
Externí odkaz:
https://doaj.org/article/85856cfda7054a5380fdb92c3c1771c7
Autor:
Elsa D. Garcin, Laurence Lamy, Joshua D. Amason, James Inglese, Ryan MacArthur, Jeffrey S. Rubin, Teresa L. Burgess, Catherine L. Farrell, Thomas W. Miller, Patricia Dranchak, John C. Braisted, David D. Roberts
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
PLoS ONE, Vol 14, Iss 7, p e0218897 (2019)
CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels in a wide variety of tumor types. This has led to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9f71df68c89b0c1dc0cddf807f4f74
http://europepmc.org/articles/PMC6611588
http://europepmc.org/articles/PMC6611588
Autor:
Michael J. Iannotti, Ryan MacArthur, Richard E. Jones, Sam Michael, James Inglese, Dingyin Tao, Ilyas Singeç
Publikováno v:
ACS chemical biology. 14(3)
Nearly one third of the encoded proteome is comprised of secretory proteins that enable communication between cells and organ systems, playing a ubiquitous role in human health and disease. High-throughput detection of secreted proteins would enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5d02c7831e931e1ea30643ff70976b
https://pubmed.ncbi.nlm.nih.gov/31012573
https://pubmed.ncbi.nlm.nih.gov/31012573
Autor:
Avi Raveh, Teatulohi Matainaho, Giselle Tamayo-Castillo, George E. Chlipala, Ryan MacArthur, Shugeng Cao, Patricia Dranchak, Richard T. Eastman, Ken Chih-Chien Cheng, David H. Sherman, Pamela J. Schultz, Jon Clardy, James Inglese, Jing Yuan, Rajarshi Guha, Matthew T. Okoneski, Xin-zhuan Su
Publikováno v:
Journal of Natural Products, Vol.78, Núm. 10, 2015
Kérwá
Universidad de Costa Rica
instacron:UCR
Kérwá
Universidad de Costa Rica
instacron:UCR
Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can therefore be challenging to eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3cd487bbec1f92fc6630a4a00b7f14
https://doi.org/10.1021/acs.jnatprod.5b00489
https://doi.org/10.1021/acs.jnatprod.5b00489
Autor:
Patricia Dranchak, Ryan MacArthur, James Inglese, John J. Moran, John Svaren, Camila Lopez-Anido
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977222
Measurement of gene expression for high-throughput screening is an increasingly used technique that has been developed for not only gene dosage disorders resulting from disease-associated copy number variations, but also for induction/repression of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8de49ea057de64c876006803600a0db
https://doi.org/10.1007/978-1-4939-7724-6_1
https://doi.org/10.1007/978-1-4939-7724-6_1
Autor:
Scott Lovell, James Inglese, Ryan MacArthur, David L. Ross, Hao Yu, N. Mehzabeen, Nathan J. Baird, Clotilde K. S. Carlow, Kevin P. Battalie, Matthew S. Munson, Patricia Dranchak, Zhiru Li, Hiroaki Suga
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme. The iPGM active site dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87fefb9f91f3edefa6181bb53eec837
https://doi.org/10.1038/ncomms14932
https://doi.org/10.1038/ncomms14932
Autor:
Yolanda Santiago, Rajini Srinivasan, Lei Zhang, James Inglese, Rajarshi Guha, Natalia J. Martinez, Ryan MacArthur, John Svaren, John J. Moran, Gregory J. Cost, Sung-Wook Jang, Patricia Dranchak
Publikováno v:
ACS Chemical Biology
Copy number variation resulting in excess PMP22 protein causes the peripheral neuropathy Charcot-Marie-Tooth disease, type 1A. To broadly interrogate chemically sensitive transcriptional pathways controlling PMP22 protein levels, we used the targetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33928de63c99c43de882601d7b86673
http://europepmc.org/articles/PMC4245164
http://europepmc.org/articles/PMC4245164
Publikováno v:
ACS Chemical Biology. 7:1205-1213
The structural integrity of myelin formed by Schwann cells in the peripheral nervous system (PNS) is required for proper nerve conduction and is dependent on adequate expression of myelin genes including peripheral myelin protein 22 (PMP22). Conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a14beb5df02ad4755331100066ef40
https://doi.org/10.1021/cb300048d
https://doi.org/10.1021/cb300048d