Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ryan Lauchli"'
Autor:
Amanda Mathis, Wenyan Mo, Susan Long, Stephanie Anna Chan, Jill Walker, Ryan Lauchli, Martin Robert Leivers, Elizabeth M. Turner, Tony Ton, Sebastian Liehr, J. Greg Falls, John F. Miller, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 57:1964-1975
By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac356040e8f55946d9a047bcc57f508d
https://doi.org/10.1021/jm401337x
https://doi.org/10.1021/jm401337x
Autor:
Ryan Lauchli, Thomas Heel, Kersten S. Rabe, Rebekah Z. Kitto, Karolina Z. Kalbarczyk, Frances H. Arnold, Amulya Tata
Publikováno v:
Angewandte Chemie International Edition. 52:5571-5574
A synthetic substrate enables a new colorimetric screen for terpene synthase cyclization activity, facilitating the engineering of these enzymes. Using directed evolution, the thermostability of the sesquiterpene synthase BcBOT2 was increased without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cc44427cdb32093b5b9299a3ee472d
https://doi.org/10.1002/anie.201301362
https://doi.org/10.1002/anie.201301362
Publikováno v:
Current Opinion in Biotechnology. 22:809-817
Protein engineering of cytochrome P450 monooxygenases (P450s) has been very successful in generating valuable non-natural activities and properties, allowing these powerful catalysts to be used for the synthesis of drug metabolites and in biosyntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e582cf59dc29a8c16211ecf8a0eb6b2
https://doi.org/10.1016/j.copbio.2011.02.008
https://doi.org/10.1016/j.copbio.2011.02.008
Autor:
Wilhelm Boland, Ryan Lauchli
Publikováno v:
Tetrahedron. 59:149-153
A short efficient synthesis of two analogues of tetrahydrodicranenone B as well as a formal synthesis of tetrahydrodicranenone B ( 1 ) itself has been devised. The approach is based on an addition/elimination sequence of in situ prepared organocuprat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1717c25f303d664cf46fa3c82bbcca5
https://doi.org/10.1016/s0040-4020(02)01484-9
https://doi.org/10.1016/s0040-4020(02)01484-9
Publikováno v:
Organicbiomolecular chemistry. 12(23)
Mutation of the sesquiterpene synthase Cop2 was conducted with a high-throughput screen for the cyclization activity using a non-natural substrate. A mutant of Cop2 was identified that contained three amino acid substitutions. This mutant, 17H2, conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2391b3ee1ebd795536e47af9c8c12d
https://pubmed.ncbi.nlm.nih.gov/24809278
https://pubmed.ncbi.nlm.nih.gov/24809278
Synthesis of an advanced welwitindolinone intermediate via an alkylation/cyclization reaction is reported. The key step involves a one pot Lewis acid-mediated alkylation of a silylketene aminal with a furan alcohol followed by an intramolecular cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280ae899bc9545d74293997f68c58594
https://europepmc.org/articles/PMC2784123/
https://europepmc.org/articles/PMC2784123/
Publikováno v:
Organic letters. 9(12)
A type 2 N-acylnitroso intramolecular Diels−Alder reaction followed by reductive N−O bond cleavage formed the B and C rings of the Stemona alkaloid stenine. Further elaboration provided the functionalized tricyclic core.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d08499cea1c5f2f2ced6153277af7b
https://pubmed.ncbi.nlm.nih.gov/17489596
https://pubmed.ncbi.nlm.nih.gov/17489596
Autor:
Kenneth J. Shea, Ryan Lauchli
Publikováno v:
Organic letters. 8(23)
[Structure: see text] An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels-Alder reaction, with indole serving as the tether between diene and dienophile,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1950e2f27cd7859c6fb03774e30205
https://pubmed.ncbi.nlm.nih.gov/17078699
https://pubmed.ncbi.nlm.nih.gov/17078699
Publikováno v:
ChemInform. 37
A type II intramolecular Diels-Alder reaction provides access to bicyclo[5.3.1] ring systems with an imbedded bridgehead allylsilane. The Lewis acid catalyzed reactions of these compounds with aldehydes proceed efficiently and with control of stereoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d73c9ee4a761f234af9f52578271f73
https://doi.org/10.1002/chin.200601172
https://doi.org/10.1002/chin.200601172
Publikováno v:
Analytical biochemistry. 348(2)
A GC-MS-based method for the simultaneous quantification of common oxylipins along with labile and highly reactive compounds based on in situ derivatization with pentafluorobenzyl hydroxylamine to the corresponding O-2,3,4,5,6-pentafluorobenzyl oxime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dc7ada9e5f9aacc1950f78bdaaeca0
https://pubmed.ncbi.nlm.nih.gov/16307716
https://pubmed.ncbi.nlm.nih.gov/16307716