Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ryan Chau"'
Autor:
Xingyue He, Mark G. Qian, Matthew O. Duffey, Larry Cohen, Michael D. Sintchak, Mi-Sook Kim, Jessica Riceberg, Vaishali Shindi, Kelly Connolly, Jianping Guo, Agatha Zawadzka, Rachel E. Gershman, Teresa A. Soucy, Neil Bence, Zhigen Hu, Xiaofeng Yang, Shumet A. Hailu, Nina Molchinova, Nanda Gulavita, Ji Zhang, Hirotake Mizutani, Keli Song, A D Patil, Scott Freeze, Jessica Grieves, Dylan Bradley England, Roushan Afroze, James J. Minissale, Anya Lublinsky, Mitsuhiro Ito, David Lok, Scott Weston Lane, William D. Mallender, Stephen Grossman, Kara Hoar, Nitya Durvasula, Bei-Ching Chuang, Yongbo Hu, Steven P. Langston, Sai M. Pulukuri, Miho Mizutani, Ryan Chau, Nancy Bump, Katherine M. Galvin, Christopher F. Claiborne, Paul D. Greenspan, He Xu, Gaulin Jeffrey L, Melissa Gallery, Douglas Bowman, Yana Wang, Koji Ono, Mcintyre Charles
Publikováno v:
Journal of medicinal chemistry. 64(5)
SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first ste
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
This study's aim was to determine the patterns of osteoarthritis (OA) in both unicompartmental medial and lateral OA of the knee. Forty patients with medial and 20 with lateral unicompartmental knee osteoarthritis were studied to determine the locati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a1ee71445d33b21ec32c59daa3085
https://doi.org/10.1002/jor.20880
https://doi.org/10.1002/jor.20880
Autor:
Sai M Pulukuri, James Minissale, Neil F. Bence, Matt Duffey, Hirotake Mizutani, He Xu, Hu Zhigen, Lawrence R. Dick, Xingyue He, Dylan England, Erik Koenig, Pooja Shah, Xiaofeng Yang, Hua Liao, Teresa A. Soucy, James E. Brownell, Melissa Gallery, Claudia Rabino, John Newcomb, Hugues Bernard, John Bradley, Jianping Guo, Mike Sintchak, Zhong-Hua Yan, Kristina Xega, Steve Langston, Ryan Chau, Jessica Riceberg, Eric S. Lightcap
Publikováno v:
Nature chemical biology. 13(11)
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification. However, a potent and selective inhibitor targeting the SUMO pathway has been lacking. Here we describe ML-792, a mechanism-bas
Publikováno v:
Asia Pacific Journal of Marketing and Logistics. 23:270-284
PurposeThe purpose of this research is to explore how a successful global and a local brand may compete side by side in an existing market place based on consumer‐based brand equity and consumers' status‐seeking motivation for purchasing a global
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat
Autor:
Kirsten R. Poore, Lucilla Poston, Jane K. Cleal, Christopher Torrens, Tristram H. Snelling, Mark A. Hanson, Meena Shanmuganathan, Ryan Chau, Lucy R. Green, David E. Noakes
Publikováno v:
Experimental Physiology. 94:1024-1033
The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and periconceptional maternal nutritional restriction on th
Autor:
Kirsten R. Poore, Christopher Torrens, Oliver Hambidge, Lucilla Poston, Julian P. Boullin, James P. Newman, Jane K. Cleal, Ryan Chau, Lucy R. Green, Mark A. Hanson, Omar A. Khan, David E. Noakes
Publikováno v:
Proceedings of the National Academy of Sciences. 104:9529-9533
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these a
Autor:
Matthew O. Duffey, Tricia J. Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Cynthia Barrett, Indu Bharathan, Douglas Bowman, Nancy J. Bump, Ryan Chau, Courtney Cullis, Denise L. Driscoll, Amy Elder, Nancy Forsyth, Jonathan Frazer, Jianping Guo, Luyi Guo, Marc L. Hyer, David Janowick, Bheemashankar Kulkarni, Su-Jen Lai, Kerri Lasky, Gang Li, Jing Li, Debra Liao, Jeremy Little, Bo Peng, Mark G. Qian, Dominic J. Reynolds, Mansoureh Rezaei, Margaret Porter Scott, Todd B. Sells, Vaishali Shinde, Qiuju Judy Shi, Michael D. Sintchak, Francois Soucy, Kevin T. Sprott, Stephen G. Stroud, Michelle Nestor, Irache Visiers, Gabriel Weatherhead, Yingchun Ye, Natalie D’Amore
Publikováno v:
Journal of medicinal chemistry. 55(1)
This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pha
Autor:
Juan Torres Lanzas, Ryan Chau, Pedro Cascales, Pascual Parrilla, Abel Gómez-Caro, María José Roca Calvo
Publikováno v:
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 31(2)
Objective: To evaluate two different approaches used to perform fused fissures in lobectomies in terms of persistent air leak (PAL) and their impact on length of hospital stay. Methods: One hundred and nineteen patients underwent lobectomy or bilobec