Výsledky vyhledávání - "Ryan, Swenerton"

Akademický článek

Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant

Autor: Justin P. Rosenheck, DO, David J. Ross, MD, Mena Botros, MD, Alexander Wong, MD, Jonathan Sternberg, PhD, Yen-An Chen, MS, Nathan Liang, BA, Amy Baer, MS, Ebad Ahmed, PhD, Ryan Swenerton, PhD, Bernhard G. Zimmermann, PhD, Gordon Fehringer, PhD, Zachary P. Demko, PhD, Michael Olymbios, MD, Paul R. Billings, MD, PhD, Brian C. Keller, MD, PhD

Publikováno v: Transplantation Direct, Vol 8, Iss 4, p e1317 (2022)

Background. Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR] and antibody-mediated rejection [AMR]), chronic lung allograft dysfunction (CLAD)

Externí odkaz: https://doaj.org/article/9edea27d61424d5caf9b33424f5d3cb2

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Akademický článek

Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology

Autor: Eser Kirkizlar, Bernhard Zimmermann, Tudor Constantin, Ryan Swenerton, Bin Hoang, Nicholas Wayham, Joshua E. Babiarz, Zachary Demko, Robert J. Pelham, Stephanie Kareht, Alexander L. Simon, Kristine N. Jinnett, Matthew Rabinowitz, Styrmir Sigurjonsson, Matthew Hill

Publikováno v: Translational Oncology, Vol 8, Iss 5, Pp 407-416 (2015)

We demonstrate proof-of-concept for the use of massively multiplexed PCR and next-generation sequencing (mmPCR-NGS) to identify both clonal and subclonal copy-number variants (CNVs) in circulating tumor DNA. This is the first report of a targeted met

Externí odkaz: https://doaj.org/article/7d066fbaf8d04bb1b6461ca5636564b1

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Abstract P040: Mutational heterogeneity of colorectal cancers across ancestries and its implications for cancer early detection

Autor: Preethi Srinivasan, Boris Gutman, Vasily Aushev, Shruti Sharma, Taly Arbel, Hsin-Ta Wu, Meenakshi Malhotra, Raheleh Salari, Bernhard Zimmermann, Ryan Swenerton, Trupti Kawli, Breeana Mitchell, Matthew Rabinowitz, Alexey Aleshin, Johannes G. Reiter

Publikováno v: Cancer Prevention Research. 16:P040-P040

Introduction: Early cancer detection with liquid biopsies has the potential to reduce mortality rates by improving screening strategies, adoption, and adherence. Towards this, a deeper understanding of the cancer genomic landscape among patients of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63c875e7252b1a5e3af443fc413fcc6e
https://doi.org/10.1158/1940-6215.precprev22-p040

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Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant

Autor: Justin P. Rosenheck, David J. Ross, Mena Botros, Alexander Wong, Jonathan Sternberg, Yen-An Chen, Nathan Liang, Amy Baer, Ebad Ahmed, Ryan Swenerton, Bernhard G. Zimmermann, Gordon Fehringer, Zachary P. Demko, Michael Olymbios, Paul R. Billings, Brian C. Keller

Publikováno v: Transplantation direct. 8(4)

Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR] and antibody-mediated rejection [AMR]), chronic lung allograft dysfunction (CLAD), or infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe9a9ffdad9093048dba3a063bebfe7
https://pubmed.ncbi.nlm.nih.gov/35372675

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A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation

Autor: Paul J. Kim, Michael Olymbios, Alfonso Siu, Omar Wever Pinzon, Eric Adler, Nathan Liang, Ryan Swenerton, Jonathan Sternberg, Navchetan Kaur, Ebad Ahmed, Yen-An Chen, Gordon Fehringer, Zachary P. Demko, Paul R. Billings, Josef Stehlik

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 41(7)

Endomyocardial biopsy (EMB), the reference surveillance test for acute rejection (AR) in heart transplant (HTx) recipients, is invasive, costly, and shows significant interobserver variability. Recent studies indicate that donor-derived cell-free DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5668568a178812ff70be67fb14b84a
https://pubmed.ncbi.nlm.nih.gov/35577713

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Analytical Validation of a Single-nucleotide Polymorphism-based Donor-derived Cell-free DNA Assay for Detecting Rejection in Kidney Transplant Patients

Autor: Bernhard Zimmermann, Rosalyn Ram, Harini Ravi, Ryan Swenerton, Meenakshi Malhotra, Yucel Altug, Allison M. Ryan, Maxim G. Brevnov, Zachary Demko, Paul Billings, Ebad Ahmed, Nathan Liang

Publikováno v: Transplantation

Supplemental Digital Content is available in the text.
Background. Early detection of rejection in kidney transplant recipients holds the promise to improve clinical outcomes. Development and implementation of more accurate, noninvasive methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284fa82e7b893b292b6f8a51e526f685
https://doi.org/10.1097/tp.0000000000002665

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Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

Publikováno v: Reinert, T, Henriksen, T V, Christensen, E, Sharma, S, Salari, R, Sethi, H, Knudsen, M, Nordentoft, I, Wu, H-T, Tin, A S, Heilskov Rasmussen, M, Vang, S, Shchegrova, S, Frydendahl Boll Johansen, A, Srinivasan, R, Assaf, Z, Balcioglu, M, Olson, A, Dashner, S, Hafez, D, Navarro, S, Goel, S, Rabinowitz, M, Billings, P, Sigurjonsson, S, Dyrskjøt, L, Swenerton, R, Aleshin, A, Laurberg, S, Husted Madsen, A, Kannerup, A-S, Stribolt, K, Palmelund Krag, S, Iversen, L H, Gotschalck Sunesen, K, Lin, C-H J, Zimmermann, B G & Lindbjerg Andersen, C 2019, ' Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer ', JAMA Oncology, vol. 5, no. 8, pp. 1124-1131 . https://doi.org/10.1001/jamaoncol.2019.0528

Importance: Novel sensitive methods for detection and monitoring of residual disease can improve postoperative risk stratification with implications for patient selection for adjuvant chemotherapy (ACT), ACT duration, intensity of radiologic surveill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59acf069d0b5229abc11521aab11d94
https://pure.au.dk/ws/files/197692926/jamaoncology_reinert_2019_oi_190019.pdf

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Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma

Publikováno v: Christensen, E, Birkenkamp-Demtröder, K, Sethi, H, Shchegrova, S, Salari, R, Nordentoft, I, Wu, H-T, Knudsen, M, Lamy, P, Lindskrog, S V, Taber, A, Balcioglu, M, Vang, S, Assaf, Z, Sharma, S, Tin, A S, Srinivasan, R, Hafez, D, Reinert, T, Navarro, S, Olson, A, Ram, R, Dashner, S, Rabinowitz, M, Billings, P, Sigurjonsson, S, Andersen, C L, Swenerton, R, Aleshin, A, Zimmermann, B, Agerbæk, M, Lin, C-H J, Jensen, J B & Dyrskjøt, L 2019, ' Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma ', Journal of Clinical Oncology, vol. 37, no. 18, pp. 1547-1557 . https://doi.org/10.1200/JCO.18.02052

PURPOSE Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately outcome for patients with bladder cancer. We addressed the prognostic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc2a7402f41354ed6512f2af9d18c8b
https://pure.au.dk/portal/da/publications/early-detection-of-metastatic-relapse-and-monitoring-of-therapeutic-efficacy-by-ultradeep-sequencing-of-plasma-cellfree-dna-in-patients-with-urothelial-bladder-carcinoma(ae7edf8e-e90c-4709-9f9c-20a1316cbc31).html

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