Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant

Autor: Justin P. Rosenheck, DO, David J. Ross, MD, Mena Botros, MD, Alexander Wong, MD, Jonathan Sternberg, PhD, Yen-An Chen, MS, Nathan Liang, BA, Amy Baer, MS, Ebad Ahmed, PhD, Ryan Swenerton, PhD, Bernhard G. Zimmermann, PhD, Gordon Fehringer, PhD, Zachary P. Demko, PhD, Michael Olymbios, MD, Paul R. Billings, MD, PhD, Brian C. Keller, MD, PhD

Publikováno v: Transplantation Direct, Vol 8, Iss 4, p e1317 (2022)

Background. Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR] and antibody-mediated rejection [AMR]), chronic lung allograft dysfunction (CLAD)

Externí odkaz: https://doaj.org/article/9edea27d61424d5caf9b33424f5d3cb2

Abstract P040: Mutational heterogeneity of colorectal cancers across ancestries and its implications for cancer early detection

Autor: Preethi Srinivasan, Boris Gutman, Vasily Aushev, Shruti Sharma, Taly Arbel, Hsin-Ta Wu, Meenakshi Malhotra, Raheleh Salari, Bernhard Zimmermann, Ryan Swenerton, Trupti Kawli, Breeana Mitchell, Matthew Rabinowitz, Alexey Aleshin, Johannes G. Reiter

Publikováno v: Cancer Prevention Research. 16:P040-P040

Introduction: Early cancer detection with liquid biopsies has the potential to reduce mortality rates by improving screening strategies, adoption, and adherence. Towards this, a deeper understanding of the cancer genomic landscape among patients of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63c875e7252b1a5e3af443fc413fcc6e
https://doi.org/10.1158/1940-6215.precprev22-p040

A novel donor-derived cell-free DNA assay for the detection of acute rejection in heart transplantation

Autor: Paul J. Kim, Michael Olymbios, Alfonso Siu, Omar Wever Pinzon, Eric Adler, Nathan Liang, Ryan Swenerton, Jonathan Sternberg, Navchetan Kaur, Ebad Ahmed, Yen-An Chen, Gordon Fehringer, Zachary P. Demko, Paul R. Billings, Josef Stehlik

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 41(7)

Endomyocardial biopsy (EMB), the reference surveillance test for acute rejection (AR) in heart transplant (HTx) recipients, is invasive, costly, and shows significant interobserver variability. Recent studies indicate that donor-derived cell-free DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5668568a178812ff70be67fb14b84a
https://pubmed.ncbi.nlm.nih.gov/35577713

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

Autor: Thomas Reinert, Katrine Stribolt, Zoe June Assaf, Lene Hjerrild Iversen, Matthew Rabinowitz, Ryan Swenerton, Ramya Srinivasan, Samantha Navarro, Lars Dyrskjøt, Claus L. Andersen, Tenna V Henriksen, Anne-Sofie Kannerup, Søren Vang, Alexander Olson, Shruti Goel, Alexey Aleshin, Michael Knudsen, Scott Dashner, Styrmir Sigurjonsson, Mustafa Balcioglu, Emil Christensen, Anders Husted Madsen, Cheng-Ho Jimmy Lin, Raheleh Salari, Paul Billings, Himanshu Sethi, Søren Krag, Mads Rasmussen, Søren Laurberg, Shruti Sharma, Bernhard Zimmermann, Svetlana Shchegrova, Amanda Frydendahl Boll Johansen, Antony Tin, Dina Hafez, Hsin-Ta Wu, Iver Nordentoft, Kåre Gotschalck Sunesen

Publikováno v: Reinert, T, Henriksen, T V, Christensen, E, Sharma, S, Salari, R, Sethi, H, Knudsen, M, Nordentoft, I, Wu, H-T, Tin, A S, Heilskov Rasmussen, M, Vang, S, Shchegrova, S, Frydendahl Boll Johansen, A, Srinivasan, R, Assaf, Z, Balcioglu, M, Olson, A, Dashner, S, Hafez, D, Navarro, S, Goel, S, Rabinowitz, M, Billings, P, Sigurjonsson, S, Dyrskjøt, L, Swenerton, R, Aleshin, A, Laurberg, S, Husted Madsen, A, Kannerup, A-S, Stribolt, K, Palmelund Krag, S, Iversen, L H, Gotschalck Sunesen, K, Lin, C-H J, Zimmermann, B G & Lindbjerg Andersen, C 2019, ' Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer ', JAMA Oncology, vol. 5, no. 8, pp. 1124-1131 . https://doi.org/10.1001/jamaoncol.2019.0528

Importance: Novel sensitive methods for detection and monitoring of residual disease can improve postoperative risk stratification with implications for patient selection for adjuvant chemotherapy (ACT), ACT duration, intensity of radiologic surveill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59acf069d0b5229abc11521aab11d94
https://pure.au.dk/ws/files/197692926/jamaoncology_reinert_2019_oi_190019.pdf

Abstract 913: Early detection of metastatic relapse and monitoring of therapeutic efficacy by ultra-deep sequencing of plasma cell-free DNA in patients with urothelial bladder carcinoma

Autor: Svetlana Shchegrova, Lars Dyrskjøt, Ann Taber, Rosie Ram, Matthew Rabinowitz, Alexey Aleshin, Mads Agerbæk, Ryan Swenerton, Emil Christensen, Mustafa Balcioglu, Thomas Reinert, Michael Knudsen, Jørgen Bjerggaard Jensen, Samantha Navarro, Philippe Lamy, Cheng-Ho J. Lin, Karin Birkenkamp-Demtröder, Zoe June Assaf, Paul Billings, Styrmir Sigurjonsson, Scott Dashner, Sia Viborg Lindskrog, Raheleh Salari, Hsin-Ta Wu, Dina Hafez, Iver Nordentoft, Antony Tin, Søren Vang, Bernhard Zimmermann, Alexander Olson, Claus L. Andersen, Ramya Srinivasan, Shruti Sharma, Himanshu Sethi

Publikováno v: Cancer Research. 79:913-913

Background Circulating tumor DNA (ctDNA) analysis is an emerging field for diagnosis, monitoring of treatment efficacy and detection of disease recurrence in various cancers. In bladder cancer, previous work has demonstrated prognostic value of ctDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbf623aeb0df1e9af9b378aaed5dfde7
https://doi.org/10.1158/1538-7445.am2019-913