Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ryan, Norcross"'
Autor:
Magang Shou, Ryan Norcross, Ping Lu, Brian A. Carr, Catherine Booth-Genthe, Yulin Fang, A. David Rodrigues, Tom Rushmore
Publikováno v:
Drug Metabolism and Disposition. 34:1703-1712
The rhesus monkey (Macaca mulatta) is a primate species used extensively as a preclinical safety species in drug development. In this report, we describe the cloning, expression, and characterization of CYP3A64 (AY334551), a CYP3A4 homolog expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3748da3b97d804d1d41edf8f5f91a858
https://doi.org/10.1124/dmd.106.009977
https://doi.org/10.1124/dmd.106.009977
Autor:
Magang Shou, Irina A. Pikuleva, Natalia Mast, Ulla Andersson, Ryan Norcross, Ingemar Björkhem, Kazuo Nakayama
Publikováno v:
Biochemistry. 42:14284-14292
The known activity of cytochrome P450 46A1 (P450 46A1) is 24(S)-hydroxylation of cholesterol. This reaction produces biologically active oxysterol, 24(S)-hydroxycholesterol, and is also the first step in enzymatic degradation of cholesterol in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22540c276e667e9775e351a8e63507c
https://doi.org/10.1021/bi035512f
https://doi.org/10.1021/bi035512f
Autor:
Yuh Lin, Ryan Norcross, Magang Shou, Thomas H. Rushmore, Yinghe Li, A. David Rodrigues, Qin Mei, Ping Lu, Grit Sandig
Publikováno v:
Drug Metabolism and Disposition. 31:1161-1169
Seven dog cytochromes P450 (P450s) were heterologously expressed in baculovirus-Sf21 insect cells. Of all enzymes examined, CYP1A1 exhibited high 7-ethoxyresorufin O -deethylase activity (low K m enzyme, 1 μM). CYP2B11 and CYP3A12 effectively cataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dc02b0aa8e42a0f7da102afa43f0e0
https://doi.org/10.1124/dmd.31.9.1161
https://doi.org/10.1124/dmd.31.9.1161
Autor:
Danielle H. Euler, Meissner Robert S, Chang Bai, Christopher J. Bungard, Azriel Schmidt, Yulin Fang, Ryan Norcross, George D. Hartman, Philip E. Brandish, Jesse J. Manikowski, Charles D. Thompson, James C. Hershey, Tom Rushmore, James J. Perkins
Publikováno v:
Bioorganicmedicinal chemistry. 19(24)
A series of partial agonists of the Glucocorticoid Receptor were prepared targeting reduced transactivation activity, while maintaining significant transrepression activity. Incorporation of an ortho-aryl amide produced compounds with the desired in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e7740297c2caf8031e66ac21ef7f9b
https://pubmed.ncbi.nlm.nih.gov/22079253
https://pubmed.ncbi.nlm.nih.gov/22079253
Autor:
Kazuo Nakayama, Ryan Norcross, Magang Shou, Ulla Andersson, Ingemar Björkhem, Natalia Mast, Irina A. Pikuleva
Publikováno v:
Neurobiology of Aging. 25:S526
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb419145590abd0bb3272f35125a9b9c
https://doi.org/10.1016/s0197-4580(04)81736-6
https://doi.org/10.1016/s0197-4580(04)81736-6
Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.
Autor:
Magang, Shou, Ryan, Norcross, Grit, Sandig, Ping, Lu, Yinghe, Li, Yuh, Lin, Qin, Mei, David, Rodrigues A, H, Rushmore Thomas
Publikováno v:
Drug Metabolism and Disposition; September 2003, Vol. 31 Issue: 9 p1161-9, 9p